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Medical School"}, {"subitem_text_language": "en", "subitem_text_value": "Department of General Surgery, Kawasaki Medical School"}, {"subitem_text_language": "en", "subitem_text_value": "Department of General Surgery, Kawasaki Medical School"}, {"subitem_text_language": "en", "subitem_text_value": "Department of General Surgery, Kawasaki Medical School"}, {"subitem_text_language": "en", "subitem_text_value": "Department of General Surgery, Kawasaki Medical School"}, {"subitem_text_language": "en", "subitem_text_value": "Department of General Surgery, Kawasaki Medical School"}, {"subitem_text_language": "en", "subitem_text_value": "Department of General Surgery, Kawasaki Medical School"}, {"subitem_text_language": "en", "subitem_text_value": "Department of General Medicine 2, Kawasaki Medical School"}, {"subitem_text_language": "en", "subitem_text_value": "Department of General Medicine 2, Kawasaki Medical School"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pathology 1, Kawasaki Medical School"}, {"subitem_text_language": "en", "subitem_text_value": "Department of General Surgery, Kawasaki Medical School"}]}, "item_3_textarea_10": {"attribute_name": "抄録(日)", "attribute_value_mlt": [{"subitem_textarea_language": "ja", "subitem_textarea_value": "症例は50歳代,女性.20XX 年1月ごろより前屈での心窩部付近の疼痛と右季肋部違和感を認めていた.同年3月初旬に疼痛が増強したため近医を受診し,CTで胆嚢に造影効果のある腫瘤と肝内の腫瘤陰影が認められた.肝転移を伴う胆嚢癌が疑われ,精査加療目的に当院へ紹介された.当院での画像検査でも胆嚢底部から体部にかけて約4.5cm大の隆起性病変を認めた.胆嚢底部では漿膜面が腫瘤に引き込まれ陥入している像を認め,肝床と一部で接しており境界不明瞭ではあったが,肝実質内への浸潤像は認めなかった.肝S4に約2cm大のリング状に造影される腫瘤を認め,肝転移が疑われた.ERCPでは胆嚢頸部,胆嚢管,総胆管への浸潤は認めなかった.胆汁細胞診はClass Vであった.単発の肝転移以外には遠隔転移を認めず,主要血管への浸潤も認めないため肝S4a+5切除,胆嚢摘出術,リンパ節郭清を施行した.切除標本では,病変は約4.5cm大の乳頭・結節型であり漿膜外まで浸潤していた(T3).組織学的には腺管構造を呈する腺癌とシナプトフィジン,クロモグラニンAが陽性の内分泌細胞癌が混在していた.肝転移巣は約2cmの結節・浸潤型であり,組織学的には同様にCD56強陽性,シナプトフィジン,クロモグラニンA陽性となる内分泌細胞癌が認められた(M1).リンパ節転移は認めなかった(N0).病理診断は腺内分泌細胞癌,UICC Stage-IVBであった.本症例は孤立性の肝転移を伴った胆嚢癌であったが,肝転移がS4であり,通常の胆嚢癌手術の切除範囲内であり,大きなリスクもなかったため,切除手術を行った.術後,gemcitabineとcisplatinによる補助化学療法を行った."}]}, "item_3_textarea_11": {"attribute_name": "抄録(英)", "attribute_value_mlt": [{"subitem_textarea_language": "en", "subitem_textarea_value": "A 57 year-old-female was referred to our hospital, because of an epigastric pain and discomfort for 2 months. Contrast-enhanced CT showed the tumor in the gallbladder body with a liver tumor in S4. An ERCP and other examinations showed no evidence of invasion to bile duct, vessels and other distant metastasis. It was diagnosed as the gallbladder cancer with a solitary liver metastasis. Preoperatively, we assessed that the curative operation might be possible. Then, we performed subsegmentectomy of liver S4a+5, cholecystectomy, and lymphadenectomy. The gallbladder cancer invasion remained extra serosa and no direct invasion to the liver tissue. Immuno-histochemical examinations showed that the tumor contained tubular adenocarcinoma and endocrine cell carcinoma with synaptophysin and chromogranin A positive. Also, the metastasis in liver S4 showed almost same results in synaptophysin, chromogranin A and CD56 positive. According to those results, she was diagnosed as mixed adeno - neuroendocrine carcinoma and Stage-IVB. Although she recovered uneventfully, she developped other liver metastases, 4 months after surgery. The chemotherapy including gemcitabine and cisplatin was introduced. Clinical cases of mixed adenoneuroendocrine carcinoma of gallbladder have been rarely reported. We present this case with a review of literatures."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "石田, 尚正", "creatorNameLang": "ja"}, {"creatorName": "イシダ, ナオマサ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "111304", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "浦上, 淳", "creatorNameLang": "ja"}, {"creatorName": "ウラカミ, アツシ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "111305", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "高岡, 宗徳", "creatorNameLang": "ja"}, {"creatorName": "タカオカ, ムネノリ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "111306", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "林, 次郎", "creatorNameLang": "ja"}, {"creatorName": "ハヤシ, ジロウ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "111307", "nameIdentifierScheme": 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"Other"}, {"subitem_subject": "Gallbladder cancer", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Liver metastasis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Liver resection", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "肝転移を伴う胆嚢腺内分泌細胞癌の一例", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "肝転移を伴う胆嚢腺内分泌細胞癌の一例", "subitem_title_language": "ja"}, {"subitem_title": "A case of mixed adenoneuroendocrine carcinoma of gallbladder with liver metastasis", "subitem_title_language": "en"}]}, "item_type_id": "3", "owner": "31", "path": ["560"], "permalink_uri": 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肝転移を伴う胆嚢腺内分泌細胞癌の一例
https://kwmed.repo.nii.ac.jp/records/1667
https://kwmed.repo.nii.ac.jp/records/166726b157b8-5d0d-4ad6-a9fa-8334c18e5db6
名前 / ファイル | ライセンス | アクション |
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KJ00009578019.pdf (2.3 MB)
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Item type | [ELS]学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-01-23 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 肝転移を伴う胆嚢腺内分泌細胞癌の一例 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | A case of mixed adenoneuroendocrine carcinoma of gallbladder with liver metastasis | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
石田, 尚正
× 石田, 尚正× 浦上, 淳× 高岡, 宗徳× 林, 次郎× 繁光, 薫× 吉田, 和弘× 山辻, 知樹× 羽井佐, 実× 後藤, 大輔× 河本, 博文× 物部, 泰昌× 猶本, 良夫× Ishida, Naomasa× Urakami, Atsushi× Takaoka, Munenori× Hayashi, Jiro× Shigemitsu, Kaori× Yoshida, Kazuhiro× Yamatsuji, Tomoki× Haisa, Minoru× Goto, Daisuke× Kawamoto, Hirofumi× Monobe, Yasumasa× Naomoto, Yoshio |
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著者所属(日) | ||||||
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川崎医科大学総合外科学 | ||||||
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川崎医科大学総合外科学 | ||||||
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川崎医科大学総合外科学 | ||||||
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川崎医科大学総合外科学 | ||||||
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川崎医科大学総合外科学 | ||||||
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川崎医科大学総合外科学 | ||||||
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川崎医科大学総合外科学 | ||||||
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川崎医科大学総合外科学 | ||||||
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川崎医科大学総合内科学2 | ||||||
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川崎医科大学総合内科学2 | ||||||
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川崎医科大学病理学1 | ||||||
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川崎医科大学総合外科学 | ||||||
著者所属(英) | ||||||
en | ||||||
Department of General Surgery, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of General Surgery, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of General Surgery, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of General Surgery, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of General Surgery, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of General Surgery, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of General Surgery, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of General Surgery, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of General Medicine 2, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of General Medicine 2, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Pathology 1, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of General Surgery, Kawasaki Medical School | ||||||
キーワード | ||||||
言語 | ja | |||||
主題Scheme | Other | |||||
主題 | 胆嚢腺内分泌細胞癌 | |||||
キーワード | ||||||
言語 | ja | |||||
主題Scheme | Other | |||||
主題 | 胆嚢癌 | |||||
キーワード | ||||||
言語 | ja | |||||
主題Scheme | Other | |||||
主題 | 肝転移 | |||||
キーワード | ||||||
言語 | ja | |||||
主題Scheme | Other | |||||
主題 | 肝切除 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Mixed adenoneuroendocrine carcinoma | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Gallbladder cancer | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Liver metastasis | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Liver resection | |||||
記事種別(日) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 症例報告 | |||||
言語 | ja | |||||
抄録(日) | ||||||
ja | ||||||
症例は50歳代,女性.20XX 年1月ごろより前屈での心窩部付近の疼痛と右季肋部違和感を認めていた.同年3月初旬に疼痛が増強したため近医を受診し,CTで胆嚢に造影効果のある腫瘤と肝内の腫瘤陰影が認められた.肝転移を伴う胆嚢癌が疑われ,精査加療目的に当院へ紹介された.当院での画像検査でも胆嚢底部から体部にかけて約4.5cm大の隆起性病変を認めた.胆嚢底部では漿膜面が腫瘤に引き込まれ陥入している像を認め,肝床と一部で接しており境界不明瞭ではあったが,肝実質内への浸潤像は認めなかった.肝S4に約2cm大のリング状に造影される腫瘤を認め,肝転移が疑われた.ERCPでは胆嚢頸部,胆嚢管,総胆管への浸潤は認めなかった.胆汁細胞診はClass Vであった.単発の肝転移以外には遠隔転移を認めず,主要血管への浸潤も認めないため肝S4a+5切除,胆嚢摘出術,リンパ節郭清を施行した.切除標本では,病変は約4.5cm大の乳頭・結節型であり漿膜外まで浸潤していた(T3).組織学的には腺管構造を呈する腺癌とシナプトフィジン,クロモグラニンAが陽性の内分泌細胞癌が混在していた.肝転移巣は約2cmの結節・浸潤型であり,組織学的には同様にCD56強陽性,シナプトフィジン,クロモグラニンA陽性となる内分泌細胞癌が認められた(M1).リンパ節転移は認めなかった(N0).病理診断は腺内分泌細胞癌,UICC Stage-IVBであった.本症例は孤立性の肝転移を伴った胆嚢癌であったが,肝転移がS4であり,通常の胆嚢癌手術の切除範囲内であり,大きなリスクもなかったため,切除手術を行った.術後,gemcitabineとcisplatinによる補助化学療法を行った. | ||||||
抄録(英) | ||||||
en | ||||||
A 57 year-old-female was referred to our hospital, because of an epigastric pain and discomfort for 2 months. Contrast-enhanced CT showed the tumor in the gallbladder body with a liver tumor in S4. An ERCP and other examinations showed no evidence of invasion to bile duct, vessels and other distant metastasis. It was diagnosed as the gallbladder cancer with a solitary liver metastasis. Preoperatively, we assessed that the curative operation might be possible. Then, we performed subsegmentectomy of liver S4a+5, cholecystectomy, and lymphadenectomy. The gallbladder cancer invasion remained extra serosa and no direct invasion to the liver tissue. Immuno-histochemical examinations showed that the tumor contained tubular adenocarcinoma and endocrine cell carcinoma with synaptophysin and chromogranin A positive. Also, the metastasis in liver S4 showed almost same results in synaptophysin, chromogranin A and CD56 positive. According to those results, she was diagnosed as mixed adeno - neuroendocrine carcinoma and Stage-IVB. Although she recovered uneventfully, she developped other liver metastases, 4 months after surgery. The chemotherapy including gemcitabine and cisplatin was introduced. Clinical cases of mixed adenoneuroendocrine carcinoma of gallbladder have been rarely reported. We present this case with a review of literatures. | ||||||
書誌情報 |
ja : 川崎医学会誌 en : Kawasaki medical journal 巻 40, 号 2, p. 145-151, 発行日 2014 |
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URL | ||||||
識別子 | http://igakkai.kms-igakkai.com/wp/wp-content/uploads/2014/KMJ-J40(2)145.pdf | |||||
識別子タイプ | URI | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.11482/KMJ-J40(2)145 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0386-5924 | |||||
ISSN | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 2758-089X | |||||
雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00045593 | |||||
雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN12940574 | |||||
著者版フラグ | ||||||
出版タイプ | VoR |