| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2020-04-01 |
| タイトル |
|
|
タイトル |
A new signal transducer and activator of transcription 3 inhibitor, BBI608, in malignant mesothelioma cell lines |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
YAMAGISHI, Tomoko
OCHI, Nobuaki
YAMANE, Hiromichi
TAKIGAWA, Nagio
|
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Kawasaki Medical School, Department of General Internal Medicine 4, Kawasaki Medical School General Medical Center |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Kawasaki Medical School, Department of General Internal Medicine 4, Kawasaki Medical School General Medical Center |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Kawasaki Medical School, Department of General Internal Medicine 4, Kawasaki Medical School General Medical Center |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Kawasaki Medical School, Department of General Internal Medicine 4, Kawasaki Medical School General Medical Center |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
BBI608 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
IL-6 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Mesothelioma |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
STAT3 |
| 抄録(英) |
|
|
言語 |
en |
|
値 |
Chronic inflammation plays a key role in the pathogenesis of malignant pleural mesothelioma as a result of asbestos exposure. Signal transducer and activator of transcription 3 (STAT3) signaling is a major pathway for cancer inflammation. The purpose of this study was to investigate the effectiveness of a new STAT3 inhibitor, BBI608, on mesothelioma cells in vitro and in vivo . The results showed that BBI608 blocked STAT3 phosphorylation, with and without suppression of IL-6. The effects of BBI608 on STAT3 downstream target genes such as cyclin D1 and survivin involved a decrease in cell viability with induction of apoptosis and cell cycle arrest. Nuclear translocation of phosphorylated STAT3 was blocked by BBI608. In addition, the agent showed significant antitumor activity in xenograft mouse models implanted with mesothelioma cells. These findings suggest that BBI608 may be a novel agent for malignant mesothelioma. |
| 書誌情報 |
en : Kawasaki medical journal
巻 45,
p. 61-73,
発行日 2019
|
| 出版者 |
|
|
出版者 |
Kawasaki Medical Society |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
03850234 |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
24343404 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12685295 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12029005 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.11482/KMJ-E201945061 |
| 記事種別(英) |
|
|
内容記述 |
Regular Article |
|
言語 |
en |
| 医中誌ID |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
ICHUSHI |
|
|
関連識別子 |
2020354379 |
| 関連サイト |
|
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
http://igakkai.kms-igakkai.com/wp/wp-content/uploads/2019en/KMJ-E201945061.pdf |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
PDF (3.0 MB)
