{"created":"2023-06-19T10:29:31.752909+00:00","id":1635,"links":{},"metadata":{"_buckets":{"deposit":"4b7c8864-32cd-4b63-84d4-1e5a017ef59d"},"_deposit":{"created_by":31,"id":"1635","owners":[31],"pid":{"revision_id":0,"type":"depid","value":"1635"},"status":"published"},"_oai":{"id":"oai:kwmed.repo.nii.ac.jp:00001635","sets":["1709617079800:35:307:555"]},"author_link":["111649","111650","111651","111652","111653","111654","111655","111656","111657","111658","111659","111660","111661","111662","111663","111664","111665","111666","111667","111668","111669","111670","111671","111672"],"item_1694495855422":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_3_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"59","bibliographicPageStart":"55","bibliographicVolumeNumber":"39","bibliographic_titles":[{"bibliographic_title":"川崎医学会誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Kawasaki medical journal","bibliographic_titleLang":"en"}]}]},"item_3_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"症例報告","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_3_identifier_14":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"http://igakkai.kms-igakkai.com/wp/wp-content/uploads/2013/KMJ31(1)55-59.2013.pdf"}]},"item_3_relation_20":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11482/2013/KMJ31(1)55-59.2013.pdf","subitem_relation_type_select":"DOI"}}]},"item_3_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00045593","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AN12940574","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0386-5924","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"2758-089X","subitem_source_identifier_type":"EISSN"}]},"item_3_text_6":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学腎臓・高血圧内科学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学腎臓・高血圧内科学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学腎臓・高血圧内科学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学腎臓・高血圧内科学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学腎臓・高血圧内科学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学腎臓・高血圧内科学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学腎臓・高血圧内科学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学腎臓・高血圧内科学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学腎臓・高血圧内科学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学腎臓・高血圧内科学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学腎臓・高血圧内科学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学腎臓・高血圧内科学"}]},"item_3_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Nephrology and Hypertension, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Nephrology and Hypertension, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Nephrology and Hypertension, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Nephrology and Hypertension, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Nephrology and Hypertension, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Nephrology and Hypertension, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Nephrology and Hypertension, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Nephrology and Hypertension, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Nephrology and Hypertension, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Nephrology and Hypertension, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Nephrology and Hypertension, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Nephrology and Hypertension, Kawasaki Medical School"}]},"item_3_textarea_10":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"症例は83歳,男性.近医で関節リウマチの診断で加療(プレドニゾロン2mg,メソトレキサート(MTX)4mg),他に高尿酸血症,高血圧で加療中であった.当院へ入院13日前にミゾリビン(MZ)150mg追加投与された.入院2日前に食欲不振と全身倦怠感で近医を受診,尿素窒素99.5mg/dl,クレアチニン7.8mg/dlと急性腎不全を認めたため当院へ紹介入院した.入院時の検査所見で尿酸26.5mg/dLと著明な高尿酸血症を認めMZによる急性尿酸性腎症と診断した.そのためMZ及び尿酸の除去を目的に緊急血液透析を施行した.尿酸値及び腎機能は速やかに改善した.しかし,入院後より血小板及び白血球数の減少を認めた.骨髄検査では骨髄異形成症候群様であり,MZに加えMTXの関与を推測された.その後汎血球減少も改善している.本症例はMZの血中濃度も高くMZの排泄遅延による高尿酸血症のため急性腎不全を合併し更に腎機能の増悪がMTXによる無効造血を発症した可能性が考えられた.MZと尿酸も血液透析により体外への除去が可能でありMZによる急性尿酸性腎症の場合は早急な血液透析が有効である."}]},"item_3_textarea_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"An 83-year-old man was diagnosed with rheumatoid arthritis at a nearby hospital for which he was administered methotrexate (MTX) and prednisolone. Thirteen days before admission, he had started mizoribine (MZ) 150mg. Two days before admission to our hospital, he was admitted to a nearby hospital for appetite loss and general fatigue. Laboratory tests showed renal dysfunction at nearby hospital, and he was consequently admitted to our hospital for further examination. On admission, we reasoned that renal dysfunction had resulted from hyperuricemia during MZ administration because the serum concentration of uric acid (26.5mg/dL) and MZ (trough level, 5.14μg/mL) were markedly elevated. Accordingly, MZ treatment was terminated, and hemodialysis was initiated. The patient subsequently showed an improvement in his condition and renal function recovered. However, pancytopenia developed soon after admission, and bone marrow aspiration showed myelodysplastic syndrome-like lesions. We suspected MTX and MZ to be the main cause of pancytopenia. Because the onset of acute renal failure had been attributed to MZ, it was conjectured that the dose of MTX was too high. Therefore, MTX administration was cancelled, and pancytopenia ameliorated. In cases of transient renal dysfunction with MZ, it is necessary to consider discontinuation of MZ and initiation of hemodialysis."}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"藤本, 壮八","creatorNameLang":"ja"},{"creatorName":"フジモト, ソウハチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山内, 佑","creatorNameLang":"ja"},{"creatorName":"ヤマウチ, ユウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"十川, 裕史","creatorNameLang":"ja"},{"creatorName":"ソガワ, ヒロシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"内田, 篤志","creatorNameLang":"ja"},{"creatorName":"ウチダ, アツシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"笛木, 孝明","creatorNameLang":"ja"},{"creatorName":"フエキ, タカアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"桑原, 篤憲","creatorNameLang":"ja"},{"creatorName":"クワバラ, アツノリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"春名, 克祐","creatorNameLang":"ja"},{"creatorName":"ハルナ, ヨシスケ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"堀家, 英之","creatorNameLang":"ja"},{"creatorName":"ホリケ, ヒデユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"佐藤, 稔","creatorNameLang":"ja"},{"creatorName":"サトウ, ミノル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"駒井, 則夫","creatorNameLang":"ja"},{"creatorName":"コマイ, ノリオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"佐々木, 環","creatorNameLang":"ja"},{"creatorName":"ササキ, タマキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"柏原, 直樹","creatorNameLang":"ja"},{"creatorName":"カシハラ, ナオキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujimoto, Sohachi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamauchi, Yu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sogawa, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Uchida, Atushi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fueki, Takaaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kuwabara, Atsunori","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Haruna, Yoshisuke","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Horike, Hideyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Minoru","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Komai, Norio","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sasaki, Tamaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kashihara, Naoki","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-01-23"}],"displaytype":"detail","filename":"KJ00008397199.pdf","filesize":[{"value":"872.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00008397199.pdf","objectType":"fulltext","url":"https://kwmed.repo.nii.ac.jp/record/1635/files/KJ00008397199.pdf"},"version_id":"f4b0813f-be17-40c7-8356-8e90538b0512"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ミゾリビン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"高尿酸性腎症","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"血液透析","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"メソトレキサート","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"骨髄抑制","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"急性腎不全","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Acute renal failure","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Hyperuricemia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Mizoribine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Hemodialysis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ミゾリビンによる急性尿酸性腎症とメソトレキサートによる骨髄抑制を併発した1例","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ミゾリビンによる急性尿酸性腎症とメソトレキサートによる骨髄抑制を併発した1例","subitem_title_language":"ja"},{"subitem_title":"Acute renal failure with marked hyperuricemia due to mizoribine associated with methotrexate-induced myeloid suppression: a case report","subitem_title_language":"en"}]},"item_type_id":"3","owner":"31","path":["555"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-01-23"},"publish_date":"2017-01-23","publish_status":"0","recid":"1635","relation_version_is_last":true,"title":["ミゾリビンによる急性尿酸性腎症とメソトレキサートによる骨髄抑制を併発した1例"],"weko_creator_id":"31","weko_shared_id":-1},"updated":"2023-10-11T03:27:40.705785+00:00"}