{"created":"2023-06-19T10:29:34.391900+00:00","id":1679,"links":{},"metadata":{"_buckets":{"deposit":"b82f2cce-7368-41e7-8850-c81df70604e7"},"_deposit":{"created_by":31,"id":"1679","owners":[31],"pid":{"revision_id":0,"type":"depid","value":"1679"},"status":"published"},"_oai":{"id":"oai:kwmed.repo.nii.ac.jp:00001679","sets":["1709617079800:35:317:563"]},"author_link":[],"item_1694495855422":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_3_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"119","bibliographicPageStart":"103","bibliographicVolumeNumber":"41","bibliographic_titles":[{"bibliographic_title":"川崎医学会誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Kawasaki medical journal","bibliographic_titleLang":"en"}]}]},"item_3_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_3_description_9":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Original Article","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_3_identifier_14":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"http://igakkai.kms-igakkai.com/wp/wp-content/uploads/2015/KMJ-J41(2)103.pdf"}]},"item_3_relation_20":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11482/KMJ-J41(2)103","subitem_relation_type_select":"DOI"}}]},"item_3_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00045593","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AN12940574","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0386-5924","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"2758-089X","subitem_source_identifier_type":"EISSN"}]},"item_3_text_6":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学解剖学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学解剖学"}]},"item_3_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Anatomy Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Anatomy Kawasaki Medical School"}]},"item_3_textarea_10":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"嗅球は比較的少数のニューロン種から構成される明瞭な層構造を持つ脳の領域である.投射ニューロンである僧帽細胞/房飾細胞は嗅球の表層の糸球体で匂い情報を受け,細胞体に至る過程で種々の介在ニューロンからの調整を受け,処理された情報を高次中枢へ投射する.情報入力部である糸球体には傍糸球体細胞(JGニューロン)が多数分布しており,形態的および化学的性質からtype 1 JGニューロンとtype 2 JGニューロンの2種の介在ニューロン群に分類される.γ-アミノ酪酸免疫陽性ニューロン(GABAニューロン)とcalbindin 免疫陽性ニューロン(CBニューロン)およびcalretinin免疫陽性ニューロン(CR ニューロン)はそれぞれのtype 1 JGニューロンとtype 2 JGニューロンの代表的なニューロン群である.これらのニューロンは対称性シナプスを形成し,抑制性に働くと考えられているが,神経回路内でシナプス形成するニューロンが異なることから,匂い情報の処理過程において異なる働きをしていることが考えられる.また,ラット嗅球のtype 2 JGニューロンは抑制性の神経伝達物質であるGABAに免疫陰性を示すが,その伝達物質の詳細は不明である.そのため本研究では電子線トモグラフィーによりGABA免疫陽性ニューロンとGABA免疫陰性ニューロンが形成するシナプスの詳細な解析を行った.今回解析したシナプスでは,GABAニューロンとCBニューロンのシナプス間隙の大きさに有意差が認められ,GABAニューロンとCBおよびCRニューロン間でシナプス小胞の大きさに有意差がみられた.また,CBニューロンとCRニューロンの間においても小胞に形態的な違いがみられた.以上の結果から,同じGABA免疫陰性ニューロンでも含有する化学物質によってシナプスの形状が異なり,機能的特性が異なることが示唆された."}]},"item_3_textarea_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"The olfactory bulb (OB) is a brain region with distinct layers organized by projection neurons, mitral/tufted cells and different kinds of interneurons. Mitral/tufted cells extend their dendrites to glomeruli in the superficial part of the OB. Here they receive odor information and send it to higher brain regions through their axons. Mitral/tufted cells are regulated by juxta-glomerular (JG) neurons in the glomeruli. JG neurons, which surround the glomerulus, have been classified into two types, type 1 and type 2, based on morphological and chemical characteristics. Type 1 neurons are γ-amino butyric acid (GABA)-immunoreactive neurons, and type 2 neurons are calbindin (CB) and calretinin (CR)-immunoreactive neurons.Type 1 2 interneurons might play different roles in odor information processing due to their synaptic contacts onto different neuronal types. Although both types of interneurons form symmetrical synapses morphologically and because of this are expected to function as inhibitory, these synapses could have distinct functions. Interestingly, type 2 interneurons in the rat OB have been shown to be immunonegative for GABA, which is the major neurotransmitter of inhibitory synapses; their transmitter remains to be identified. Therefore, in the present study, we have conducted ultrastructural analysis of synapses formed by GABA-immunopositive and -immunonegative JG neurons by electron microscopic tomography. Results indicate statistical differences in the width of synaptic clefts between GABA- and CB-immunopositive neurons and in the size of synaptic vesicles between GABA-, CB-, and CR-immunopositive neurons. In addition, we have found some differences in the shape of synaptic vesicles between CB- and CR-immunopositive neurons. Together with the findings of our previous studies, we have shown distinct structural differences of synapses in subgroups of type 2 neurons and differences between type1 and 2 interneurons. These structural differences differ with the different proteins expressed in the interneurons and could indicate different functional properties of the subgroups of interneurons."}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"野津, 英司","creatorNameLang":"ja"},{"creatorName":"ノツ, エイジ","creatorNameLang":"ja-Kana"}]},{"creatorNames":[{"creatorName":"樋田, 一徳","creatorNameLang":"ja"},{"creatorName":"トイダ, カズノリ","creatorNameLang":"ja-Kana"}]},{"creatorNames":[{"creatorName":"Notsu, Eiji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Toida, Kazunori","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-01-23"}],"displaytype":"detail","filename":"KJ00010041319.pdf","filesize":[{"value":"1.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00010041319.pdf","objectType":"fulltext","url":"https://kwmed.repo.nii.ac.jp/record/1679/files/KJ00010041319.pdf"},"version_id":"f3281199-6124-4ffb-bdff-4d17a269fb22"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ラット嗅球","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"電子線トモグラフィー","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"GABA","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"calbindin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"calretinin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Rat olfactory bulb","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Electron tomography","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"GABA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Calbindin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Calretinin","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ラット嗅球神経回路における非GABA系介在ニューロンのシナプス結合の微細構造解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ラット嗅球神経回路における非GABA系介在ニューロンのシナプス結合の微細構造解析","subitem_title_language":"ja"},{"subitem_title":"Ultrastructural analysis of synaptic contacts of non-GABAergic interneurons in the rat main olfactory bulb.","subitem_title_language":"en"}]},"item_type_id":"3","owner":"31","path":["563"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-01-23"},"publish_date":"2017-01-23","publish_status":"0","recid":"1679","relation_version_is_last":true,"title":["ラット嗅球神経回路における非GABA系介在ニューロンのシナプス結合の微細構造解析"],"weko_creator_id":"31","weko_shared_id":-1},"updated":"2023-10-11T02:09:07.758604+00:00"}