{"created":"2023-06-19T10:28:01.629226+00:00","id":181,"links":{},"metadata":{"_buckets":{"deposit":"589ca418-0041-4d41-84a7-1b36a976ab56"},"_deposit":{"created_by":3,"id":"181","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"181"},"status":"published"},"_oai":{"id":"oai:kwmed.repo.nii.ac.jp:00000181","sets":["1709617079800:37:61:347"]},"author_link":["127028","127025","127027","127030","127029","127026"],"item_3_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1986","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"87","bibliographicPageStart":"83","bibliographicVolumeNumber":"12","bibliographic_titles":[{},{"bibliographic_title":"Kawasaki medical journal","bibliographic_titleLang":"en"}]}]},"item_3_description_9":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Original Article","subitem_description_type":"Other"}]},"item_3_identifier_14":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"http://igakkai.kms-igakkai.com/wp/wp-content/uploads/1986en/12(2)83-87.1986.pdf | http://igakkai.kms-igakkai.com/wp/wp-content/uploads/1986en/12(2)83-87.1986.pdf"}]},"item_3_relation_20":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11482/KMJ-E12(2)83 ","subitem_relation_type_select":"DOI"}}]},"item_3_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA00710169","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12029005","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-0234","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"2434-3404","subitem_source_identifier_type":"ISSN"}]},"item_3_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Division of Endocrinology, Department of Medicine, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Division of Endocrinology, Department of Medicine, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Division of Endocrinology, Department of Medicine, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Division of Endocrinology, Department of Medicine, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Division of Endocrinology, Department of Medicine, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Division of Endocrinology, Department of Medicine, Kawasaki Medical School "}]},"item_3_textarea_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"3H-spiperone, a dopaminergic antagonist, was used to study binding sites in rat adrenal glomerulosa membrane. The equilibrium dissociation constant (Kd) and binding capacity for 3H-spiperone binding were 2.2 nM and 268 fmol/mg protein, respectively. Determination of the Kd by kinetic studies provided a value of 2.6 nM, which corresponded closely to the Kd estimated by equilibrium studies. In a study of the subcellular distribution of dopamine receptors in adrenal glomerulosa cells, 3H-spiperone binding activity at the interface of density 1.14 to 1.16 accounted for 60% of the total activity in all fractions. These dopaminergic binding sites in adrenal glomerulosa cells may modulate aldosterone secretion induced by antidopaminergic agents. 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