{"created":"2023-06-19T10:29:46.334754+00:00","id":1879,"links":{},"metadata":{"_buckets":{"deposit":"1bf40ece-59b5-413d-b4a6-4d11e97aa818"},"_deposit":{"created_by":31,"id":"1879","owners":[31],"pid":{"revision_id":0,"type":"depid","value":"1879"},"status":"published"},"_oai":{"id":"oai:kwmed.repo.nii.ac.jp:00001879","sets":["1709617079800:35:604:605"]},"author_link":["110419","110420","110421","110422","110423","110424","110425","110426","110427","110428","110429","110430","110431","110432","110433","110434","110435","110436"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"15","bibliographicPageStart":"9","bibliographicVolumeNumber":"43","bibliographic_titles":[{"bibliographic_title":"川崎医学会誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Kawasaki medical journal","bibliographic_titleLang":"en"}]}]},"item_10001_description_33":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"症例報告","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10001_description_34":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Case Report","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"川崎医学会","subitem_publisher_language":"ja"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11482/KMJ-J43(1)9","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://igakkai.kms-igakkai.com/wp/wp-content/uploads/2017/KMJ-J43(1)9.pdf","subitem_relation_type_select":"URI"}}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00045593","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AN12940574","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0386-5924","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"2758-089X","subitem_source_identifier_type":"EISSN"}]},"item_10001_text_31":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学リウマチ・膠原病学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学リウマチ・膠原病学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学リウマチ・膠原病学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学リウマチ・膠原病学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学リウマチ・膠原病学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学皮膚科学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学皮膚科学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学皮膚科学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学リウマチ・膠原病学"}]},"item_10001_text_32":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Rheumatology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Rheumatology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Rheumatology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Rheumatology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Rheumatology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Dermatology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Dermatology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Dermatology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Rheumatology, Kawasaki Medical School"}]},"item_10001_textarea_5":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"Systemic lupus erythematosus is an autoimmune disease that can cause wide-spread inflammation affecting multiple organs. Most gastrointestinal involvement in systemic lupus erythematosus is lupus enteritis and lupus mesenteric vasculitis; proteinlosing gastroenteropathy is rare. We report a patient with protein-losing gastroenteropathy in association with steroid-resistant systemic lupus erythematosus who was successfully treated with cyclophosphamide pulse therapy. A woman in her 20s was referred to our hospital because of systemic edema and dyspnea from laryngeal edema. Laboratory tests showed hypoalbuminemia, positive ANA and anti-SSA tests, and low serum levels of complement. 99mTc-human serum albumin scintigraphy showed a localized area of protein loss in the gastrointestinal tract. A diagnosis of protein-losing gastroenteropathy in association with systemic lupus erythematosus was made. She was started on high-dose corticosteroid therapy including methylprednisolone pulse therapy for over 2 weeks, but therapy was not effective. We then started intravenous administration of cyclophosphamide (700 mg) with prednisolone and the patient’s general status improved as evidenced by increased urine output. In patients with protein-losing gastroenteropathy associated with systemic lupus erythematosus who are not responsive to high-dose corticosteroid therapy, it is important to use an immunosuppressive agent in combination with prednisolone at an early stage."}]},"item_10001_textarea_6":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"全身性エリテマトーデスは，全身の多臓器に炎症を起こし多彩な症状を引き起こす全身性自己免疫疾患である．消化器病変としては，ループス腸炎や腸間膜血管炎が多く，蛋白漏出性胃腸症を呈するのは稀である．我々はシクロホスファミドパルス療法が著効したループス関連蛋白漏出胃腸症の症例を経験した．　患者は20歳代女性．全身の浮腫と喉頭浮腫による呼吸困難感で当院に搬送され，血液検査で低アルブミン血症，抗核抗体陽性，抗SS-A 抗体陽性，低補体血症を認めた．99mTc 標識ヒト血清アルブミンによる消化管シンチグラフィにて，胃から小腸の広範囲で蛋白漏出が認められた．ループス関連蛋白漏出性胃腸症と診断し，ステロイドパルス療法を含め２週間以上のステロイド大量療法を行うも症状の改善を認めなかった．ステロイド治療に併用してシクロホスファミド700 mg の点滴を施行したところ，翌日より大量の尿排泄（5,000 ml/ 日以上）を認め，速やかに全身状態は改善した．ループス関連蛋白漏出性胃腸症は，ステロイドが奏効しない例も存在することを念頭に置き，免疫抑制薬を早期から併用することも重要である．"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"黒﨑, 奈美","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"三戸, 崇史","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"印南, 恭子","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"藤田, 俊一","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"向井, 知之","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山本, 佳子","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"林, 宏明","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"藤本, 亘","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"守田, 吉孝","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KUROSAKI, Nami","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MITO, Takafumi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"INNAMI Kyoko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"FUJITA, Shunichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MUKAI, Tomoyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YAMAMOTO, Yoshiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HAYASHI, Hiroaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"FUJIMOTO, Wataru","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MORITA, Yoshitaka","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-09-28"}],"displaytype":"detail","filename":"KMJ-J43(1)9.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PDF","objectType":"fulltext","url":"https://kwmed.repo.nii.ac.jp/record/1879/files/KMJ-J43(1)9.pdf"},"version_id":"1f7065d1-cb66-43da-b9e6-846d164fdf45"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"全身性エリテマトーデス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"蛋白漏出性胃腸症","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"99mTc 標識ヒト血清アルブミンシンチグラフィ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"シクロホスファミド","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"自己免疫疾患","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Systemic lupus erythematosus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Protein-losing gastroenteropathy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"99mTc-human serum albumin scintigraphy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cyclophosphamide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Autoimmune disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ステロイド抵抗性のループス関連蛋白漏出性胃腸症にシクロホスファミドパルス療法が有効であった１例","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ステロイド抵抗性のループス関連蛋白漏出性胃腸症にシクロホスファミドパルス療法が有効であった１例","subitem_title_language":"ja"},{"subitem_title":"A case of protein-losing gastroenteropathy in association with steroid-resistant systemic lupus erythematosus which was successfully treated with cyclophosphamide pulse therapy","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"31","path":["605"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-09-28"},"publish_date":"2017-09-28","publish_status":"0","recid":"1879","relation_version_is_last":true,"title":["ステロイド抵抗性のループス関連蛋白漏出性胃腸症にシクロホスファミドパルス療法が有効であった１例"],"weko_creator_id":"31","weko_shared_id":-1},"updated":"2024-04-15T07:25:51.971758+00:00"}