{"created":"2023-06-19T10:29:46.854987+00:00","id":1886,"links":{},"metadata":{"_buckets":{"deposit":"5f8eecdc-fba2-486d-966f-bcb1b7d9fb7d"},"_deposit":{"created_by":31,"id":"1886","owners":[31],"pid":{"revision_id":0,"type":"depid","value":"1886"},"status":"published"},"_oai":{"id":"oai:kwmed.repo.nii.ac.jp:00001886","sets":["1709617079800:35:604:611"]},"author_link":["110529","110530","110531","110532","110533","110534","110535","110536","110537","110538"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"80","bibliographicPageStart":"75","bibliographicVolumeNumber":"43","bibliographic_titles":[{"bibliographic_title":"川崎医学会誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Kawasaki medical journal","bibliographic_titleLang":"en"}]}]},"item_10001_description_33":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"症例報告","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10001_description_34":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Case Report","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"川崎医学会","subitem_publisher_language":"ja"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11482/KMJ-J43(2)75","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://igakkai.kms-igakkai.com/wp/wp-content/uploads/2017/KMJ-J43(2)75.pdf","subitem_relation_type_select":"URI"}}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00045593","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AN12940574","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0386-5924","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"2758-089X","subitem_source_identifier_type":"EISSN"}]},"item_10001_text_31":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学神経内科学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学神経内科学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学神経内科学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学神経内科学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学神経内科学"}]},"item_10001_text_32":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Neurology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Neurology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Neurology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Neurology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Neurology, Kawasaki Medical School"}]},"item_10001_textarea_5":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"A 70-year-old woman was admitted to our hospital owing to heart failure. She was treated and improved with diuretics. However, her serum CK values were persistently elevated throughout her hospitalization. She quickly developed head drop and showed muscle weakness, predominantly in the shoulders and pelvic girdles. A muscle biopsy from the right biceps brachialis revealed large variability in the myofiber size with many necrotic myofibers and few regenerative myofibers, as well as inflammatory cell infiltration. These findings combined with the immunological blood test led to a diagnosis of anti-SRP-positive myopathy, and she was treated with oral glucosteroids. However, she had frequent syncope attack 17 days after the beginning of treatment. Her ECG revealed complete atrioventral block, and she received a pacemaker implantation 3 days after the attack occurred. Her muscle weakness and hyperCKemia gradually improved by additional intravenous immunoglobulin treatment. The existence of cardiac complications of anti-SRP-positive inflammatory myopathy has been a matter of debate. Further extensive clinical observations will be required to clarify the clinical existence and the significance of anti-SRP antibodies on the pathogenesis of cardiac complications, including conduction block."}]},"item_10001_textarea_6":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"患者は70歳代前半女性．心不全で発症し，当院循環器内科で治療を受けた．心不全は利尿薬投与などで改善したが，CK 高値があり，その後に，首下がりや四肢近位筋筋力低下が出現進行したため，当科に入院した．右上腕二頭筋筋生検では，筋線維の大小不同，内部核の増加があり，壊死筋線維が多数みられたが，再生筋，myophagia や炎症細胞浸潤は軽度であった．抗体検査の結果と合わせ，抗signal recognition particle（SRP）抗体陽性ミオパチーと診断した．治療として，経口ステロイド療法を開始したが，治療開始17日目に失神発作を来たすようになった．心電図検査では完全房室ブロックであり，発作後３日目に永久ペースメーカー植え込み術を行った．経口ステロイド療法に加え，免疫グロブリン大量療法（IVIg 療法）を行ったところ，高CK 血症や頸部四肢筋力低下は徐々に改善した．抗SRP 抗体陽性ミオパチーの心合併症については，心伝導障害を含め，様々な議論があるが，これまでに完全房室ブロックを来たした報告はなく，貴重な症例と考えられた． "}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"深井, 雄太","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大澤, 裕","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"久徳, 弓子","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"逸見, 祥司","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"砂田, 芳秀","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"FUKAI, Yuta","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OHSAWA, Yutaka","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KUTOKU, Yumiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HEMMI, Shoji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SUNADA, Yoshihide","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-01"}],"displaytype":"detail","filename":"KMJ-J43(2)75.pdf","filesize":[{"value":"1.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PDF","objectType":"fulltext","url":"https://kwmed.repo.nii.ac.jp/record/1886/files/KMJ-J43(2)75.pdf"},"version_id":"1c66aea6-2df2-4262-94f9-fec9fc01c2a0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"完全房室ブロック","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"抗SRP 抗体","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ミオパチー","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Complete atrioventricular block","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Anti-signal recognition particle (anti-SRP) antibody","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Myopathy","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"完全房室ブロックを合併した抗 signal recognition particle（SRP）抗体陽性ミオパチー","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"完全房室ブロックを合併した抗 signal recognition particle（SRP）抗体陽性ミオパチー","subitem_title_language":"ja"},{"subitem_title":"Complete atrioventricular block in anti-signal recognition particle (anti-SRP) antibody-positive myopathy","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"31","path":["611"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-03-01"},"publish_date":"2018-03-01","publish_status":"0","recid":"1886","relation_version_is_last":true,"title":["完全房室ブロックを合併した抗 signal recognition particle（SRP）抗体陽性ミオパチー"],"weko_creator_id":"31","weko_shared_id":-1},"updated":"2024-04-16T01:24:53.555923+00:00"}