{"created":"2023-06-19T10:29:47.094325+00:00","id":1890,"links":{},"metadata":{"_buckets":{"deposit":"7ecaf9a1-159a-4f1d-8b6a-78fef6d42917"},"_deposit":{"created_by":31,"id":"1890","owners":[31],"pid":{"revision_id":0,"type":"depid","value":"1890"},"status":"published"},"_oai":{"id":"oai:kwmed.repo.nii.ac.jp:00001890","sets":["1709617079800:35:604:611"]},"author_link":["110591","110592","110593","110594","110595","110596","110597","110598","110599","110600","110601","110602","110603","110604","110605","110606"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"117","bibliographicPageStart":"109","bibliographicVolumeNumber":"43","bibliographic_titles":[{"bibliographic_title":"川崎医学会誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Kawasaki medical journal","bibliographic_titleLang":"en"}]}]},"item_10001_description_33":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著論文","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10001_description_34":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Regular Article","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"川崎医学会","subitem_publisher_language":"ja"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11482/KMJ-J43(2)109","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://igakkai.kms-igakkai.com/wp/wp-content/uploads/2017/KMJ-J43(2)109.pdf","subitem_relation_type_select":"URI"}}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00045593","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AN12940574","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0386-5924","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"2758-089X","subitem_source_identifier_type":"EISSN"}]},"item_10001_text_31":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学耳鼻咽喉科学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学耳鼻咽喉科学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学第２学年"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学耳鼻咽喉科学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学免疫学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学免疫学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学耳鼻咽喉科学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学耳鼻咽喉科学"}]},"item_10001_text_32":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Otorhinolaryngology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Otorhinolaryngology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"The Second Grade Student, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Otorhinolaryngology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Immunology and Molecular Genetics, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Immunology and Molecular Genetics, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Otorhinolaryngology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Otorhinolaryngology, Kawasaki Medical School"}]},"item_10001_textarea_5":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"Allergic rhinitis is not only clinically assessed, but also pathologically analyzed both in vitro and in vivo in various ways. There are a variety of mouse models for the analysis of allergic rhinitis. In one of the most well-known models, mice are sensitized by intraperitoneal injection of ovalbumin and alum adjuvant to induce allergic inflammation, and then an antigen is administered locally in the nasal cavity. This model is used for evaluating the therapeutic effects of drugs as well as for pathological analysis, leading to new treatments and clinical applications. Acquired allergy mediated by antigen-specific IgE antibodies plays an important role in allergic rhinitis. Inflammatory substances such as histamine, which are released locally from IgE-activated mast cells, induce the early phase of allergy and trigger symptoms. We developed an experimental model that allows us to analyze nasal hypersensitivity, focusing on allergic inflammation induced by degranulation of mast cells by an antigen-antibody reaction. In this model, mice are passively sensitized by intravenous injection of antigen-specific IgE, so we can approach the early phase in allergic rhinitis specially. We report this new mouse model with a literature review."}]},"item_10001_textarea_6":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"アレルギー性鼻炎は臨床における検討だけでなく，in vitro やin vivo においても様々な方法で病態解析が行われている．マウスを用いた様々なアレルギー性鼻炎解析モデルの中で代表的なものとして，抗原として卵白アルブミンを用いて感作後に鼻腔局所に抗原を投与するモデルがある．これは抗原とAlum adjuvant を腹腔内投与することによって感作を成立させてアレルギー性炎症を誘導する．このモデルは病態解析だけでなく，薬剤の治療効果判定としても用いられ，新たな治療薬の検討や臨床応用につながっている．アレルギー性鼻炎は抗原特異的IgE 抗体を介した獲得型アレルギーが重要であり，早期相の誘導にはIgE とマスト細胞を介して局所に放出されるヒスタミンなどの炎症性物質が症状を起こすきっかけとなる．今回我々は，抗原特異的IgE を静脈注射して受動感作を成立させ，抗原抗体反応を介したマスト細胞からの脱顆粒で誘導されるアレルギー性炎症を中心に解析する実験モデルを考案したので，文献的考察を踏まえて報告する． "}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"雜賀, 太郎","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"兵, 行義","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"佐野, 寛哉","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"濵本, 真一","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"矢作, 綾野","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"石原, 克彦","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"原田, 保","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"原, 浩貴","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SAIKA, Taro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HYO, Yukiyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SANO, Hiroya","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HAMAMOTO, Masakazu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YAHAGI, Ayano","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ISHIHARA, Katsuhiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HARADA, Tamotsu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HARA, Hirotaka","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-01"}],"displaytype":"detail","filename":"KMJ-J43(2)109.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PDF","objectType":"fulltext","url":"https://kwmed.repo.nii.ac.jp/record/1890/files/KMJ-J43(2)109.pdf"},"version_id":"767691ff-d98e-4ce4-94be-9a94174ee2d1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"アレルギー性鼻炎","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"鼻過敏症","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"マウスモデル","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"卵白アルブミン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"抗卵白アルブミンIgE 抗体","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"好酸球","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Allergic rhinitis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Hypersensitivity reaction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Experimental model","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Ovalbumin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Anti-Ovalbumin IgE antibody","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Eosinophil","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"新たな鼻過敏症の初期病変モデルマウスの作製","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新たな鼻過敏症の初期病変モデルマウスの作製","subitem_title_language":"ja"},{"subitem_title":"Development of a new mouse model of nasal hypersensitivity","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"31","path":["611"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-03-01"},"publish_date":"2018-03-01","publish_status":"0","recid":"1890","relation_version_is_last":true,"title":["新たな鼻過敏症の初期病変モデルマウスの作製"],"weko_creator_id":"31","weko_shared_id":-1},"updated":"2024-04-16T01:25:03.124019+00:00"}