{"created":"2023-06-19T10:29:48.636388+00:00","id":1917,"links":{},"metadata":{"_buckets":{"deposit":"ccacb491-8391-4081-899a-9084e8f65f03"},"_deposit":{"created_by":31,"id":"1917","owners":[31],"pid":{"revision_id":0,"type":"depid","value":"1917"},"status":"published"},"_oai":{"id":"oai:kwmed.repo.nii.ac.jp:00001917","sets":["1709617079800:35:616:617"]},"author_link":["110117","110118","110119","110120","110121","110122"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"25","bibliographicPageStart":"19","bibliographicVolumeNumber":"44","bibliographic_titles":[{"bibliographic_title":"川崎医学会誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Kawasaki medical journal","bibliographic_titleLang":"en"}]}]},"item_10001_description_33":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著論文","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10001_description_34":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Regular Article","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"川崎医学会","subitem_publisher_language":"ja"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11482/KMJ-J44(1)19","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://igakkai.kms-igakkai.com/wp/wp-content/uploads/2018/KMJ-J44(1)19.pdf","subitem_relation_type_select":"URI"}}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00045593","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AN12940574","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0386-5924","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"2758-089X","subitem_source_identifier_type":"EISSN"}]},"item_10001_text_31":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学乳腺甲状腺外科学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学乳腺甲状腺外科学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学乳腺甲状腺外科学"}]},"item_10001_text_32":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Breast Thyroid Surgery, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Breast Thyroid Surgery, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Breast Thyroid Surgery, Kawasaki Medical School"}]},"item_10001_textarea_5":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"　We analyzed the expression of RET/PTC 1 and 3 in thyroid cancers. We used specimens that were resected from 38 papillary thyroid carcinomas and four poorly differentiated thyroid carcinomas at our hospital. Using each extracted messenger RNA, the rearrangements of RET/PTC 1 and 3 were analyzed by a real-time PCR method. RET/PTC 1 and RET/PTC 3 expression were found in three patients (5.7%) and six patients (14.0%), respectively. Only one patient expressed both. There was no significant relationship between expression of RET/PTC and clinical features such as age, gender, tumor size, lymph node involvement, extrathyroidal infiltration, recurrence, disease-free survival or overall survival. However, younger patients tended to have a higher positive rate of RET/PTC 1 and 3, while DFS tended to be shorter in RET/PTC 1-positive patients (p=0.0563).\n　In this study, we did not find any significant relationship between RET/PTC 1 and 3 and thyroid carcinoma."}]},"item_10001_textarea_6":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"　予後良好な甲状腺癌遺伝子異常の臨床的意義は不明な点が多い．甲状腺癌におけるRET/PTC 遺伝子のうち１と３の発現を検討した．当科で初回手術を受けた甲状腺癌乳頭癌・低分化癌のうち，無作為に甲状腺乳頭癌38例と低分化癌４例を選択し，それぞれの原発巣におけるRET/PTC１，３の発現を検討した．RET/PTC１，３の発現はreal-time PCR 法により検討した．RET/PTC１は３例（5.7%）に発現が見られ，RET/PTC３は６例（14.0%）に発現が見られた．１例のみ両遺伝子の発現が見られた．年齢，性別，腫瘍径，リンパ節転移，被膜外浸潤，再発，無病期間，全生存期間の臨床データーとは有意な関係は認められなかった．年齢では有意差がないもののRET/PTC１またはRET/PTC３の陽性例は，陰性例に比し若年である傾向があった．また，RET/PTC１の発現例はDFS が短い傾向があった（p=0.0563）．今回の検討では，RET/PTC１，３の発現意義を見出すことはできなかった． "}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田中, 克浩","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"太田, 裕介","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"齋藤, 亙","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TANAKA, Katsuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OHTA, Yusuke","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SAITO, Wataru","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-03-14"}],"displaytype":"detail","filename":"KMJ-J44(1)19.pdf","filesize":[{"value":"1.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PDF","objectType":"fulltext","url":"https://kwmed.repo.nii.ac.jp/record/1917/files/KMJ-J44(1)19.pdf"},"version_id":"cf37ccae-36c4-4a5e-ace9-43dd78f29a21"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"甲状腺癌","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"PET/PTC","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"再配列","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"臨床的特徴","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Thyroid cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"RET/PTC","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Rearrangement","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Clinical features","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"甲状腺癌におけるRET/PTC 再配列遺伝子発現の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"甲状腺癌におけるRET/PTC 再配列遺伝子発現の検討","subitem_title_language":"ja"},{"subitem_title":"Analyses of expression of RET/PTC in thyroid cancer","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"31","path":["617"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-03-14"},"publish_date":"2019-03-14","publish_status":"0","recid":"1917","relation_version_is_last":true,"title":["甲状腺癌におけるRET/PTC 再配列遺伝子発現の検討"],"weko_creator_id":"31","weko_shared_id":-1},"updated":"2024-04-12T07:31:11.905055+00:00"}