{"created":"2023-06-19T10:29:48.714770+00:00","id":1918,"links":{},"metadata":{"_buckets":{"deposit":"a087e0ff-5642-4bdc-86f1-3eeab3cff5b2"},"_deposit":{"created_by":31,"id":"1918","owners":[31],"pid":{"revision_id":0,"type":"depid","value":"1918"},"status":"published"},"_oai":{"id":"oai:kwmed.repo.nii.ac.jp:00001918","sets":["1709617079800:35:616:617"]},"author_link":["110123","110124","110125","110126","110127","110128","110129","110130","110131","110132","110133","110134","110135","110136"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"33","bibliographicPageStart":"27","bibliographicVolumeNumber":"44","bibliographic_titles":[{"bibliographic_title":"川崎医学会誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Kawasaki medical journal","bibliographic_titleLang":"en"}]}]},"item_10001_description_33":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"症例報告","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10001_description_34":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Case Report","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"川崎医学会","subitem_publisher_language":"ja"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11482/KMJ-J44(1)27","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://igakkai.kms-igakkai.com/wp/wp-content/uploads/2018/KMJ-J44(1)27.pdf","subitem_relation_type_select":"URI"}}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00045593","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AN12940574","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0386-5924","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"2758-089X","subitem_source_identifier_type":"EISSN"}]},"item_10001_text_31":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学血液内科学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学血液内科学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学血液内科学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学病理学１"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学病理学１"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学血液内科学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学血液内科学"}]},"item_10001_text_32":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Pathology 1, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Pathology 1, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"}]},"item_10001_textarea_5":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"　Adult onset alveolar rhabdomyosarcoma is rare, but recurrence is common and prognosis is poor. Various types of chemotherapy regimens have been attempted, but few studies have reported information on efficacy. Here, we report our experience with a patient who received Vincristine Irinotecan Temozolomide (VITA) therapy and in whom long-term (complete response: CR) was maintained. The patient was a 20-year-old man who developed alveolar rhabdomyosarcoma in the clivus of the sella turcica. Following enucleation and postoperative radiotherapy, lesion disappeared by CT was achieved. However, right cervical lymphadenopathy was soon apparent, and a lymphadenectomy was performed. Because left cervical lymphadenopathy was apparent after 2 months, the Children's Oncology Group ARST0431 regimen (54 weeks of therapy: blocks of therapy with VI, interval compression with VDC/IE and VAC) was initiated, negative PET imaging and lesion disappeared by CT was achieved. However, reappearance of left cervical lymphadenopathy was noted after 1 year. Recurrence was diagnosed in the patient, and VITA therapy was initiated again. CR was achieved after 6 courses, and subsequent outpatient follow-up has revealed that CR has been maintained. Hence, VITA therapy may be useful for treatment-resistant alveolar rhabdomyosarcoma and should be considered as a treatment option."}]},"item_10001_textarea_6":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"　成人発症の胞巣型横紋筋肉腫は，まれであり，再発しやすく予後が悪いと言われている．さまざまな化学療法が試されているが効果的な報告は少ない．我々は，難治性胞巣型横紋筋肉腫に対してVincristine Irinotecan Temozolomide（VITA）療法を施行し，長期完全奏効（Complete Response：CR）を維持している症例を経験したため報告する．症例は20歳代の男性で，トルコ鞍斜台に腫瘍を認め，摘出生検を施行し胞巣型横紋筋肉腫と診断された．残存腫瘤に対して放射線治療を施行し，CT 検査で病変の消失を確認した．術後３か月後に右頸部リンパ節腫大が出現し，リンパ節郭清術を施行した．その２か月後に左頸部リンパ節腫大が出現したため，Childrens Oncology Group ARST0431レジメン（VI 療法とVDC/IE 交代療法およびVAC 療法によるブロックから構成される計54週間の治療）を施行し，PET/CT でFDG 集積の消失を確認し，CT でもリンパ節腫大病変は消失した．しかし，１年後に左頸部リンパ節腫大が再度出現．再発と判断し，VITA 療法を開始した．６コース施行しCT にてCR を確認した．以後，外来で経過観察中でありCR を維持している．難治性胞巣型横紋筋肉腫に対してVITA 療法は有用であると考えられ，治療法の選択枝の一つとして考慮すべきである． "}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"佐野, 史典","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"近藤, 敏範","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"清水, 里紗","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"西村, 広健","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"定平, 吉都","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"和田, 秀穂","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"杉原, 尚","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SANO, Fuminori","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KONDO, Toshinori","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SHIMIZU, Risa","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NISHIMURA, Hirotake","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SADAHIRA, Yoshito","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"WADA, Hideho","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SUGIHARA, Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-03-14"}],"displaytype":"detail","filename":"KMJ-J44(1)27.pdf","filesize":[{"value":"5.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PDF","objectType":"fulltext","url":"https://kwmed.repo.nii.ac.jp/record/1918/files/KMJ-J44(1)27.pdf"},"version_id":"81acac1d-0db5-4719-8379-ac9b4f623825"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"胞巣型横紋筋肉腫","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"VITA 療法","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"テモゾロミド","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Alveolar Rhabdomyosarcoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"VITA therapy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Temozolomide","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"成人発症の難治性胞巣型横紋筋肉腫に対する Vincristine Irinotecan Temozolomide 療法を用いた治療経験","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"成人発症の難治性胞巣型横紋筋肉腫に対する Vincristine Irinotecan Temozolomide 療法を用いた治療経験","subitem_title_language":"ja"},{"subitem_title":"Treatment experience with Vincristine Irinotecan and Temozolomide to Adult relapsed Alveolar Rhabdomyosarcoma","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"31","path":["617"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-03-14"},"publish_date":"2019-03-14","publish_status":"0","recid":"1918","relation_version_is_last":true,"title":["成人発症の難治性胞巣型横紋筋肉腫に対する Vincristine Irinotecan Temozolomide 療法を用いた治療経験"],"weko_creator_id":"31","weko_shared_id":-1},"updated":"2024-04-12T07:31:11.896111+00:00"}