{"created":"2023-06-19T10:29:48.932313+00:00","id":1921,"links":{},"metadata":{"_buckets":{"deposit":"dd466e12-226b-4253-b4b0-05de2af51e6b"},"_deposit":{"created_by":31,"id":"1921","owners":[31],"pid":{"revision_id":0,"type":"depid","value":"1921"},"status":"published"},"_oai":{"id":"oai:kwmed.repo.nii.ac.jp:00001921","sets":["1709617079800:35:616:617"]},"author_link":["110181","110182","110183","110184","110185","110186","110187","110188","110189","110190","110191","110192","110193","110194","110195","110196","110197","110198","110199","110200","110201","110202","110203","110204","110205","110206"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"55","bibliographicPageStart":"49","bibliographicVolumeNumber":"44","bibliographic_titles":[{"bibliographic_title":"川崎医学会誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Kawasaki medical journal","bibliographic_titleLang":"en"}]}]},"item_10001_description_33":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"症例報告","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10001_description_34":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Case 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of Hematology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"}]},"item_10001_textarea_5":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"　Cryptococcal infections are fungal infections caused by Cryptococcus neoformans. This infection develops more commonly in immunocompromised patients. We report two cases of cryptococcal meningitis that developed as a result of CD4 lymphocytopenia. Case 1 was a man in his 40s who presented with a fever of unknown origin. A blood test revealed a lymphocyte count of 930/μL, with no meningeal irritation; however, examination of his cerebrospinal fluid detected cryptococcal bodies, which was also confirmed by blood culture. In addition, the patient had a low CD4 count of 72.5/μL, and was HIV antibodypositive. We thus diagnosed him as an AIDS patient who developed cryptococcal meningitis. Case 2 was a woman in her 20s who also presented with a fever of unknown origin. A blood test revealed a lymphocyte count of 510/μL, with no meningeal irritation; however, examination of her cerebrospinal fluid detected cryptococcal bodies, which was confirmed by blood culture. Despite the patient having a low CD4 count of 19.4/μL, she was HIV antibody-negative, and there was no evidence of primary immunodeficiency or any other causes of immune deficiency. Accordingly, we diagnosed this patient as cryptococcal meningitis that developed as a result of idiopathic CD4 lymphocytopenia (ICL). In the above cases, cryptococcal meningitis developed as a result of AIDS and ICL, respectively. The incidence rates of this complication are reported as 2.4% for the former and 19.7% for the latter. When cryptococcal meningitis without HIV infection is observed, it is necessary to consider the possibility of CD4 lymphocytopenia due to ICL. Although cryptococcal meningitis can be fatal, treatment was successful in both cases, and more than one year has elapsed since their initial presentation."}]},"item_10001_textarea_6":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"　クリプトコッカス感染症はCryptococcus neoformans による真菌感染症であり，免疫不全患者に発症しやすい．今回，我々はCD4リンパ球減少を認め，クリプトコッカス髄膜炎を発症した２例を経験したので報告する．症例１は，40歳代男性で不明熱のため受診した．血液検査でリンパ球930/μL，髄膜刺激症状はなかったが，髄液検査にてクリプトコッカス菌体が検出され，血液培養からも検出された．CD4 72.5/μL と低値であり，HIV 抗体陽性であった．クリプトコッカス髄膜炎を発症したAIDS 患者と診断した．症例２は，20歳代女性で不明熱のため受診した．血液検査でリンパ球510/μL，髄膜刺激症状はなかったが，髄液検査にてクリプトコッカス菌体が検出され，血液培養からも検出された．CD4 19.4/μL と低値であったが，HIV 抗体陰性で原発性免疫不全症や他の免疫不全となる原因は認められなかった．Idiopathic CD4 lymphocytopenia（ICL）に発症したクリプトコッカス髄膜炎と診断した．AIDS とICL がそれぞれ原因となったクリプトコッカス髄膜炎であった．前者での本症併発は2.4 %，後者での併発は19.7 % と報告されている．HIV非感染のクリプトコッカス髄膜炎をみた際にはICL によるCD4リンパ球減少症を考える必要がある．死に至ることもまれではないクリプトコッカス髄膜炎であるが，治療が奏効し１年以上経過しているため報告する． "}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"横井, 桃子","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"佐野, 史典","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"松本, 誠司","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"安井, 晴之進","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"内田, 圭一","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"清水, 里紗","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"廣瀬, 匡","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"竹内, 麻子","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"徳永, 博俊","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"近藤, 敏範","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"松橋, 佳子","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"和田, 秀穂","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"杉原, 尚","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YOKOI, Momoko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SANO, Fuminori","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MATSUMOTO, Seiji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YASUI, Harunoshin","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"UCHIDA, Keiichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SHIMIZU, Risa","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HIROSE, Tadashi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAKEUCHI, Asako","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TOKUNAGA, Hirotoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KONDO, Toshinori","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MATSUHASHI, Yoshiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"WADA, Hideho","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SUGIHARA, Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-03-14"}],"displaytype":"detail","filename":"KMJ-J44(1)49.pdf","filesize":[{"value":"992.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PDF","objectType":"fulltext","url":"https://kwmed.repo.nii.ac.jp/record/1921/files/KMJ-J44(1)49.pdf"},"version_id":"0f8f2dc0-8149-4cd6-9a6f-e2ab6a88fe25"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ICL","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"特発性CD4陽性Tリンパ球減少症","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"クリプトコッカス髄膜炎","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ICL","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Idiopathic CD4 lymphocytopenia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cryptococcal meningitis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"クリプトコッカス髄膜炎を発症したCD4リンパ球減少症の２例","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"クリプトコッカス髄膜炎を発症したCD4リンパ球減少症の２例","subitem_title_language":"ja"},{"subitem_title":"Two cases of cryptococcal meningitis developing as a result of CD4 lymphocytopenia","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"31","path":["617"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-03-14"},"publish_date":"2019-03-14","publish_status":"0","recid":"1921","relation_version_is_last":true,"title":["クリプトコッカス髄膜炎を発症したCD4リンパ球減少症の２例"],"weko_creator_id":"31","weko_shared_id":-1},"updated":"2024-04-12T07:31:21.091039+00:00"}