{"created":"2023-06-19T10:29:49.084596+00:00","id":1923,"links":{},"metadata":{"_buckets":{"deposit":"9f992fbd-b252-4995-981f-21d3a1c7b6c4"},"_deposit":{"created_by":31,"id":"1923","owners":[31],"pid":{"revision_id":0,"type":"depid","value":"1923"},"status":"published"},"_oai":{"id":"oai:kwmed.repo.nii.ac.jp:00001923","sets":["1709617079800:35:616:617"]},"author_link":["110237","110238","110239","110240","110241","110242"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"69","bibliographicPageStart":"65","bibliographicVolumeNumber":"44","bibliographic_titles":[{"bibliographic_title":"川崎医学会誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Kawasaki medical journal","bibliographic_titleLang":"en"}]}]},"item_10001_description_33":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"症例報告","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10001_description_34":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Case Report","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"川崎医学会","subitem_publisher_language":"ja"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11482/KMJ-J44(1)65","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://igakkai.kms-igakkai.com/wp/wp-content/uploads/2018/KMJ-J44(1)65.pdf","subitem_relation_type_select":"URI"}}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00045593","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AN12940574","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0386-5924","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"2758-089X","subitem_source_identifier_type":"EISSN"}]},"item_10001_text_31":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学総合内科学１"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学総合内科学１"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学総合内科学１"}]},"item_10001_text_32":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Kawasaki Medical School, Department of General Internal Medicine 1, Kawasaki Medical School General Medical Center"},{"subitem_text_language":"en","subitem_text_value":"Kawasaki Medical School, Department of General Internal Medicine 1, Kawasaki Medical School General Medical Center"},{"subitem_text_language":"en","subitem_text_value":"Kawasaki Medical School, Department of General Internal Medicine 1, Kawasaki Medical School General Medical Center"}]},"item_10001_textarea_5":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"　The patient was a 92-year–old woman, who was being treated at a nearby clinic for hypertension and dementia. She received Shakuyaku-kanzo-To, an herbal medicine for muscle pain and four months previously she had been started on a loop diuretic agent because of leg edema. However, her serum potassium gradually decreased to 2.1 mmol/L. Therefore, both Shakuyaku-Kanzo-To and the loop diuretic agent were discontinued and administration of potassium supplement was initiated. But, she noticed muscle weakness and was admitted to our hospital. Laboratory data revealed a serum potassium level of 1.8mmol/L. She was diagnosed with rhabdomyolysis indicated by markedly high levels of CPK and urinary myoglobin. On admission, she presented with low plasma rennin activity and hypoaldosteronism, as well as high urinary excretion of potassium. We diagnosed her with pseudoaldosteronism caused by the licorice extracts contained in Syakuyaku-Kanzo-To. Discontinuation of Shakuyaku-Kanzo-To and potassium supplementation successfully normalized her electrolyte imbalance. Because Shakuyaku-Kanzo-To has relatively few adverse effects, its use by elderly patients is continuing to increase. We think it is important to create awareness of the possible adverse effects of Shakuyaku-Kanzo-To."}]},"item_10001_textarea_6":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"　症例は92歳，女性．近医で高血圧や認知症で通院加療中であった．下肢の疼痛に対し，芍薬甘草湯が処方されていた．入院4か月前から下肢の浮腫が出現したためにループ利尿薬の内服が開始された．入院10日前の血液検査で血清カリウム値2.1 mmol/L と低カリウム血症であったために芍薬甘草湯とループ利尿薬の休薬を指示し，カリウム製剤の内服が開始となっていた．入院当日の朝、自宅内を歩行中に転倒し動けなくなったところを近隣の人に発見され当院へ救急搬送となった．受診時，著明な低カリウム血症（1.8 mmol/L），CK 3.612 U/L から低カリウム血症による横紋筋融解症と診断し，補液とカリウム補正を開始した．入院時の検査で低レニン・低アルドステロン血症，尿中カリウム排泄亢進を認めた．甘草を含有する芍薬甘草湯による偽性アルドステロン症と診断し，同剤の中止とカリウム補正によって入院10日目にほぼ正常化した．高齢者において，漢方薬は比較的副作用が少ないことから処方される機会が多い．しかし，高齢者では多数の内服薬が処方されることが多く，各薬剤の服用状況や副作用，それらの相互作用について注意する必要があると考えられる．"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"依光, 大祐","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大城, 義之","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"沖本, 二郎","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YORIMITSU, Daisuke","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OSHIRO, Yoshiyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OKIMOTO, Niro","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-03-14"}],"displaytype":"detail","filename":"KMJ-J44(1)65.pdf","filesize":[{"value":"839.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PDF","objectType":"fulltext","url":"https://kwmed.repo.nii.ac.jp/record/1923/files/KMJ-J44(1)65.pdf"},"version_id":"feb47bfa-c5e1-4b34-99e5-dd066edd2288"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"漢方薬","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"利尿薬","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"低カリウム血症","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"横紋筋融解症","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Herbal medicine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Diuretic agent","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Hypokalemia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Rhabdomyolysis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"漢方薬と利尿薬による低カリウム血症によって横紋筋融解症が誘発された１例","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"漢方薬と利尿薬による低カリウム血症によって横紋筋融解症が誘発された１例","subitem_title_language":"ja"},{"subitem_title":"A Case of Hypokalemic Rhabdomyolysis induced by a Chinese herbal medicine and a loop diuretic agent","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"31","path":["617"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-03-14"},"publish_date":"2019-03-14","publish_status":"0","recid":"1923","relation_version_is_last":true,"title":["漢方薬と利尿薬による低カリウム血症によって横紋筋融解症が誘発された１例"],"weko_creator_id":"31","weko_shared_id":-1},"updated":"2024-04-12T07:31:25.546857+00:00"}