{"created":"2023-06-19T10:29:49.964922+00:00","id":1936,"links":{},"metadata":{"_buckets":{"deposit":"1c786eea-42b0-4d1d-9be2-fa5ab5a0a74d"},"_deposit":{"created_by":31,"id":"1936","owners":[31],"pid":{"revision_id":0,"type":"depid","value":"1936"},"status":"published"},"_oai":{"id":"oai:kwmed.repo.nii.ac.jp:00001936","sets":["1709617079800:35:616:623"]},"author_link":["110317","110318","110319","110320","110321","110322","110323","110324","110325","110326","110327","110328","110329","110330","110331","110332","110333","110334","110335","110336","110337","110338","110339","110340","110341","110342"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"120","bibliographicPageStart":"115","bibliographicVolumeNumber":"44","bibliographic_titles":[{"bibliographic_title":"川崎医学会誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Kawasaki medical journal","bibliographic_titleLang":"en"}]}]},"item_10001_description_33":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著論文","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10001_description_34":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Regular 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南岡山医療センター呼吸器内科）"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学総合内科学４"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学総合内科学４"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学総合内科学４"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学総合内科学４"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学総合内科学４"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学総合内科学４"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学総合内科学４"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学麻酔・集中治療医学２"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学総合医療センター薬剤部"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学総合医療センター薬剤部"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学総合医療センター薬剤部"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学総合内科学４"}]},"item_10001_text_32":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Kawasaki Medical School, Department of General Internal Medicine 4, Kawasaki Medical School General Medical Center\n(Present affiliation: Department of Respiratory Medicine, Minami-Okayama Medical Center)"},{"subitem_text_language":"en","subitem_text_value":"Kawasaki Medical School, Department of General Internal Medicine 4, Kawasaki Medical School General Medical Center"},{"subitem_text_language":"en","subitem_text_value":"Kawasaki Medical School, Department of General Internal Medicine 4, Kawasaki Medical School General Medical Center"},{"subitem_text_language":"en","subitem_text_value":"Kawasaki Medical School, Department of General Internal Medicine 4, Kawasaki Medical School General Medical Center"},{"subitem_text_language":"en","subitem_text_value":"Kawasaki Medical School, Department of General Internal Medicine 4, Kawasaki Medical School General Medical Center"},{"subitem_text_language":"en","subitem_text_value":"Kawasaki Medical School, Department of General Internal Medicine 4, Kawasaki Medical School General Medical Center"},{"subitem_text_language":"en","subitem_text_value":"Kawasaki Medical School, Department of General Internal Medicine 4, Kawasaki Medical School General Medical Center"},{"subitem_text_language":"en","subitem_text_value":"Kawasaki Medical School, Department of General Internal Medicine 4, Kawasaki Medical School General Medical Center"},{"subitem_text_language":"en","subitem_text_value":"Department of Anesthesia 2, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department Pharmaceuticals, General Medical Center, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department Pharmaceuticals, General Medical Center, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department Pharmaceuticals, General Medical Center, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Kawasaki Medical School, Department of General Internal Medicine 4, Kawasaki Medical School General Medical Center"}]},"item_10001_textarea_5":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"　Lubiprostone is a useful treatment for opioid-induced constipation (OIC); however, it is not known whether the treatment is suitable for OIC in patients undergoing cancer chemotherapy. This study evaluated hospitalized patients receiving cancer chemotherapy in whom OIC was treated with lubiprostone between October 2014 and February 2016. The control group consisted of OIC + chemotherapy patients who were hospitalized between April 2012 and September 2014, before lubiprostone was approved for use at our hospital. Frequency of stool and food intake were retrospectively evaluated before and after treatment with lubiprostone (lubiprostone group; n=7) or other laxative agent (control group; n=12). Other laxative agents included sennoside, sodium picosulfate, daikenchuto or magnesia. The lubiprostone and control groups both received oxycodone (median [range]: 39.3 [10.0-125.7] mg vs 10.0 [10.0-62.9] mg; P=0.103). The day following treatment, defecation was observed in 6 of 7 patients in the lubiprostone group and 3 of 12 patients in the control group (P<0.05). Dietary intake also increased in 6 of 7 patients in the lubiprostone group and 3 of 12 patients in the control group (P<0.05). Therefore, lubiprostone may be an effective treatment for OIC during chemotherapy."}]},"item_10001_textarea_6":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"　当科において2014年10月から2016年２月に入院で化学療法を施行し，がん性疼痛に対して使用したオピオイドにより誘発された便秘に対してルビプロストンを投与した全症例を対象とした．対照群は，当院のルビプロストン採用以前の2012年４月から2014年９月まで，化学療法施行中にオピオイドを使用した患者に緩下薬を使用していた全症例とした．ルビプロストンを追加してからの排便回数と食事量の変化を後方視的に解析した．対照群の排便回数と食事量の変化は，新たな緩下薬（センノシド，ピコスルファートナトリウム，または大建中湯）の追加または酸化マグネシウムを増量した前後を基準とした．ルビプロストン使用群７人，未使用の対照群12人で，オキシコドン換算の使用量中央値（範囲）は対照群で10.0（10.0～62.9）mg，ルビプロストン群で39.3（10.0～125.7）mg であった（P=0.103）．ルビプロストン群ではその投与翌日に７例中６人，対照群においては12例中３例で排便が認められた（P<0.05）．ルビプロストン群においては排便があった翌日の食事摂取量は７例中６例，対照群は12例中３例で改善していた（P<0.05）．化学療法施行中にもオピオイドによる便秘に対するルビプロストンが有用であることが示唆された．"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"本多, 宣裕","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山根, 弘路","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"越智, 宣昭","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"中川, 望","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"長﨑, 泰有","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"河原, 辰由樹","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山岸, 智子","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"中西, 秀和","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"西江, 宏行","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"渡辺, 麻里子","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"草信, 晴美","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"監物, 英男","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"瀧川, 奈義夫","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HONDA, Yoshihiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YAMANE, Hiromichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OCHI, Nobuaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NAKAGAWA, Nozomu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NAGASAKI, Yasunari","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KAWAHARA, Tatsuyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YAMAGISHI, Tomoko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NAKANISHI, Hidekazu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NISHIE, Hiroyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"WATABABE, Mariko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KUSANOBU, Harumi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KENMOTSU, Hideo","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAKIGAWA, Nagio","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-04-04"}],"displaytype":"detail","filename":"KMJ-J44(2)115.pdf","filesize":[{"value":"851.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PDF","objectType":"fulltext","url":"https://kwmed.repo.nii.ac.jp/record/1936/files/KMJ-J44(2)115.pdf"},"version_id":"7d20024f-9033-4613-ba5f-2207249fc145"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"化学療法","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"オピオイド","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"便秘","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ルビプロストン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Chemotherapy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"opioid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"constipation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"lubiprostone","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal 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