{"created":"2023-06-19T10:29:50.038499+00:00","id":1937,"links":{},"metadata":{"_buckets":{"deposit":"0fc7e507-1a99-4813-8dfa-347f9ad09b0b"},"_deposit":{"created_by":31,"id":"1937","owners":[31],"pid":{"revision_id":0,"type":"depid","value":"1937"},"status":"published"},"_oai":{"id":"oai:kwmed.repo.nii.ac.jp:00001937","sets":["1709617079800:35:616:623"]},"author_link":["110343","110344","110345","110346","110347","110348","110349","110350","110351","110352","110353","110354","110355","110356","110357","110358","110359","110360","110361","110362","110363","110364","110365","110366","110367","110368","110369","110370","110371","110372"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"128","bibliographicPageStart":"121","bibliographicVolumeNumber":"44","bibliographic_titles":[{"bibliographic_title":"川崎医学会誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Kawasaki medical journal","bibliographic_titleLang":"en"}]}]},"item_10001_description_33":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"症例報告","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10001_description_34":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Case 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of Hematology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Pathology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"}]},"item_10001_textarea_5":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"Post-transplantation lymphoproliferative disorder (PTLD) occurs as a result of the use of immunosuppressants following hematopoietic stem cell transplantation, which causes the emergence of abnormal lymphocytes owing to the decline in T-cell function and the proliferation of plasma cells. It is thus one of the most fatal complications and the biggest concern for transplantation cases. PTLD is classified into 4 categories, and monomorphic PTLD takes the form of a malignant lymphoma. Immunosuppressant dose reduction, rituximab (R) monotherapy, and R-CHOP therapy are used to treat monomorphic PTLD, but the prognosis is poor for these forms of treatment. This report describes the experience of a patient with refractory PTLD who went into remission after responding to combination therapy with rituximab and bendamustine. A 50-year-old man underwent cord blood transplantation because of a myelodysplastic syndrome. Tacrolimus was used for GVHD prevention. After transplantation, symptoms of GVHD of the gastrointestinal tract developed, and during treatment using prednisolone, symptoms of monomorphic PTLD (diffuse large B-cell lymphoma) emerged. Once immunosuppressant use was discontinued, the patient underwent R monotherapy and R-CHOPlike treatment, but the response was poor. The treatment was then changed to combination therapy with rituximab and bendamustine; after 4 courses of treatment, gastrointestinal endoscopy revealed that the pathological abnormality had disappeared, and a complete response was confirmed. One year has passed since the completion of treatment, and at present, the patient’s symptoms have not worsened, suggesting that combination therapy with rituximab and bendamustine is effective for treating monomorphic PTLD."}]},"item_10001_textarea_6":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"　移植後リンパ増殖性疾患（PTLD）は，造血幹細胞移植後に免疫抑制剤を使用した結果として，Ｔ細胞機能が低下して生じる異常なリンパ球，または形質細胞の増殖で，移植領域において最も致死的で注意を要する合併症の一つである．PTLD は４つのカテゴリーに分類され，その中のmonomorphic PTLD は、悪性リンパ腫の形態を呈する．Monomorphic PTLD の治療には，免疫抑制剤減量，リツキシマブ（Ｒ）単独療法やR-CHOP 療法があるが，予後は不良である．今回，難治性PTLD に対してリツキシマブ併用ベンダムスチン療法が奏効し寛解をえることができた症例を経験したので報告する．症例は50歳代男性で、骨髄異形成症候群に対して臍帯血移植を施行し，GVHD 予防にタクロリムスを使用した．移植後，消化管GVHD を発症し，プレドニゾロンで治療中，monomorphic PTLD（びまん性大細胞型Ｂ細胞リンパ腫）を発症した．免疫抑制剤中止後，リツキシマブ（Ｒ）単独療法，R-CHOP like 療法を施行したが効果不良であった．リツキシマブ併用ベンダムスチン療法に変更し４コース施行後，消化管内視鏡検査で病変は消失し，CT 検査で完全奏効を確認した．治療終了し約１年経過しているが，現在も症状増悪なく経過できており，難治性monomorphic PTLD に対してリツキシマブ併用ベンダムスチン療法が有効であった． "}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松本, 誠司","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"清水, 里紗","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"佐野, 史典","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"内田, 圭一","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"横井, 桃子","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"安井, 晴之進","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山田, 聖子","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"竹内, 麻子","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"廣瀬, 匡","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"西村, 広健","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"徳永, 博俊","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"近藤, 敏範","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"松橋, 佳子","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"近藤, 英生","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"和田, 秀穂","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MATSUMOTO, Seiji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SHIMIZU, Risa","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SANO, Fuminori","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"UCHIDA, Keiichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YOKOI, Momoko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YASUI, Harunoshin","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YAMADA, Seiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAKEUCHI, Asako","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HIROSE, Tadashi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NISHIMURA, Hirotake","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TOKUNAGA, Hirotoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KONDO, Toshinori","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MATSUHASHI, Yoshiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KONDO, Eisei","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"WADA, Hideho","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-04-04"}],"displaytype":"detail","filename":"KMJ-J44(2)121.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PDF","objectType":"fulltext","url":"https://kwmed.repo.nii.ac.jp/record/1937/files/KMJ-J44(2)121.pdf"},"version_id":"e3f54fcb-167f-4588-8b9d-4142a8f7af36"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ベンダムスチン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"PTLD","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"DLBCL","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Bendamustine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"post-transplant lymphoproliferative disorders","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"DLBCL","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"リツキシマブ併用ベンダムスチン療法が奏効した腸管monomorphic PTLD","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"リツキシマブ併用ベンダムスチン療法が奏効した腸管monomorphic PTLD","subitem_title_language":"ja"},{"subitem_title":"Response to combination therapy with rituximab and bendamustine for intestinal monomorphic PTLD","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"31","path":["623"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-04-04"},"publish_date":"2019-04-04","publish_status":"0","recid":"1937","relation_version_is_last":true,"title":["リツキシマブ併用ベンダムスチン療法が奏効した腸管monomorphic PTLD"],"weko_creator_id":"31","weko_shared_id":-1},"updated":"2024-04-13T02:55:14.161076+00:00"}