{"created":"2023-06-19T10:30:04.794960+00:00","id":2170,"links":{},"metadata":{"_buckets":{"deposit":"8e0f5bdd-617e-4aa1-a6aa-c9549302cc18"},"_deposit":{"created_by":31,"id":"2170","owners":[31],"pid":{"revision_id":0,"type":"depid","value":"2170"},"status":"published"},"_oai":{"id":"oai:kwmed.repo.nii.ac.jp:00002170","sets":["1709617079800:35:686"]},"author_link":["109671","109672","109673","109674","109675","109676","109677","109678","109679","109680","109681","109682"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"53","bibliographicPageStart":"49","bibliographicVolumeNumber":"45","bibliographic_titles":[{"bibliographic_title":"川崎医学会誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Kawasaki medical journal","bibliographic_titleLang":"en"}]}]},"item_10001_description_33":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著論文","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10001_description_34":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Regular Article","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"川崎医学会","subitem_publisher_language":"ja"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11482/KMJ-J201945049","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://igakkai.kms-igakkai.com/wp/wp-content/uploads/2019/KMJ-J201945049.pdf","subitem_relation_type_select":"URI"}}]},"item_10001_relation_35":{"attribute_name":"医中誌ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"2020200375","subitem_relation_type_select":"ICHUSHI"}}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00045593","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AN12940574","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0386-5924","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"2758-089X","subitem_source_identifier_type":"EISSN"}]},"item_10001_text_31":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学総合内科学１"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学総合内科学１"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学総合内科学１"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学総合内科学１"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学総合内科学１"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学総合内科学１"}]},"item_10001_text_32":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of General Internal Medicine 1, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of General Internal Medicine 1, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of General Internal Medicine 1, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of General Internal Medicine 1, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of General Internal Medicine 1, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of General Internal Medicine 1, Kawasaki Medical School"}]},"item_10001_textarea_5":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"　The clinical effect and safety of Tazobactam/piperacillin and Pazufloxacin combination therapy on hospital-acquired pneumonia severe group (C group) was evaluated. Twenty patients were treated by combination of TAZ/PIPC (4.5g per dose, 3 times daily) and PZFX (500mg per dose, twice daily) .\n　Clinical effect, bacteriological effect, and adverse events were examined. Clinical efficacy rate was 60.0% (effectiveness in 12 of 20 patients). As for bacteriological effect, 3 of 3 Escherichia coli strais , 2 of 2 Streptococcus pneumoniae strains, 1 of 1 methicillin-sensitive Staphylococcus aureus strain and Serratia marcescense strain respectively, 1 of 2 Enterococcus faealis strains and Pseudomonas aeruginosa strains respectively were eradicated. In total, 9 (69.2%) of 13 strains were eradicated. Adverse events were infection site phlebitis in 3 patients (15.0%), and abnormal laboratory findings were observed including mild liver dysfunction in 4 patients and mild renal dysfunction in 4 patients. Consequently, TAZ/PIPC and PZFX combination therapy is recommended for hospital-acquired pneumonia severe group(C group)."}]},"item_10001_textarea_6":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"　院内肺炎重症群（Ｃ群）に対するTazobactam/Piperacillin（TAZ/PIPC），Pazufloxacin（PZFX）併用療法の有効性と安全性を検討した．院内肺炎重症群（C 群）20例を対象とし，TAZ/PIPC １回4.5g，１日３回， PZFX １回500mg，１日２回の併用投与を行い，その臨床効果，細菌学的効果，副作用などにつき検討した．その結果，臨床効果は，有効率60.0％（20例中12例有効）であった．細菌学的効果は，除菌率69.2％（13株中９株除菌）であり，Escherichia coli ３株中３株，Streptococcus pneumoniae ２株中２株，methicillin-sensitive Staphylococcus aureus ，Serratiamarcescense 各々１株中１株，Enterococcus faealis ，Pseudomonas aeruginosa 各々２株中１株が除菌された．副作用として，注射部位静脈炎が３例（15.0％）にみられ，臨床検査値の異常変動は８例（40.0％：肝機能障害４例，腎機能障害４例）にみられたが，いずれも軽度であった．以上より，TAZ/PIPC, PZFX 併用投与は，院内肺炎重症群（Ｃ群）に対して推奨できる治療法と考えられた．"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"沖本, 二郎","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小山, 勝正","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"福田, 直樹","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"栗原, 武幸","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"宮下, 修行","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"友田, 恒一","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OKIMOTO, Niro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KOYAMA, Katsumasa","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"FUKUDA, Naoki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KURIHARA, Takeyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MIYASHITA, Naoyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TOMODA, Koichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-04-01"}],"displaytype":"detail","filename":"KMJ-J201945049.pdf","filesize":[{"value":"891.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PDF","objectType":"fulltext","url":"https://kwmed.repo.nii.ac.jp/record/2170/files/KMJ-J201945049.pdf"},"version_id":"a4d59676-8167-444e-949b-87f52fcc3389"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"院内肺炎","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Tazobactam/Piperacillin","subitem_subject_scheme":"Other"},{"subitem_subject":"Pazufloxacin","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Hospital-acquired pneumonia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Tazobactam/Piperacillin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Pazufloxacin","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"院内肺炎重症群（Ｃ群）に対するTazobactam/Piperacillin, Pazufloxacin 併用療法の有効性と安全性に関する検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"院内肺炎重症群（Ｃ群）に対するTazobactam/Piperacillin, Pazufloxacin 併用療法の有効性と安全性に関する検討","subitem_title_language":"ja"},{"subitem_title":"Clinical effect and safety of Tazobactam/Piperacillin and Pazufloxacin combination therapy on hospital-acquired pneumonia severe group (C group)","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"31","path":["686"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-04-01"},"publish_date":"2020-04-01","publish_status":"0","recid":"2170","relation_version_is_last":true,"title":["院内肺炎重症群（Ｃ群）に対するTazobactam/Piperacillin, Pazufloxacin 併用療法の有効性と安全性に関する検討"],"weko_creator_id":"31","weko_shared_id":-1},"updated":"2024-04-19T04:11:01.299855+00:00"}