{"created":"2023-06-19T10:30:05.116215+00:00","id":2176,"links":{},"metadata":{"_buckets":{"deposit":"47d24aa1-8bcf-4f05-9661-e27b1e3d43c5"},"_deposit":{"created_by":31,"id":"2176","owners":[31],"pid":{"revision_id":0,"type":"depid","value":"2176"},"status":"published"},"_oai":{"id":"oai:kwmed.repo.nii.ac.jp:00002176","sets":["1709617079800:35:686"]},"author_link":["109763","109764","109765","109766","109767","109768","109769","109770","109771","109772"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"94","bibliographicPageStart":"89","bibliographicVolumeNumber":"45","bibliographic_titles":[{"bibliographic_title":"川崎医学会誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Kawasaki medical journal","bibliographic_titleLang":"en"}]}]},"item_10001_description_33":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"症例報告","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10001_description_34":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Case Report","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"川崎医学会","subitem_publisher_language":"ja"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11482/KMJ-J201945089","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://igakkai.kms-igakkai.com/wp/wp-content/uploads/2019/KMJ-J201945089.pdf","subitem_relation_type_select":"URI"}}]},"item_10001_relation_35":{"attribute_name":"医中誌ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"2020200381","subitem_relation_type_select":"ICHUSHI"}}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00045593","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AN12940574","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0386-5924","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"2758-089X","subitem_source_identifier_type":"EISSN"}]},"item_10001_text_31":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学血液内科学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学血液内科学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学血液内科学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学血液内科学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学血液内科学"}]},"item_10001_text_32":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"}]},"item_10001_textarea_5":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"　Calcineurin inhibitor-induced pain syndrome (CIPS) involves pain and itchiness that occur at sites centered on the legs while using a calcineurin inhibitor. We report about two cases of CIPS that occurred during immunosuppressive therapy for aplastic anemia. The first case was a 60-year-old woman who was found to have pancytopenia in a blood test that was conducted by her local physician. After referral to our hospital, she was diagnosed with aplastic anemia (stage 4), and we initiated ATG (antithymocyte globulin) /CyA（Cyclosporin A） combination therapy. After administering CyA, she developed discomfort and almost intolerable pain in both legs. She was diagnosed with CIPS, and her symptoms improved upon cessation of CyA. Subsequently, aplastic anemia deteriorated; therefore, CyA was restarted at a low dose. This caused CIPS to recur, and the continuation of treatment became difficult because of worsening of depression. Deterioration of the underlying condition led to the patient’s death. The second case was a 60-year-old woman who was referred to our hospital after she was found to have anemia and thrombocytopenia in a blood test. She was diagnosed with aplastic anemia (stage 2), and CyA therapy was initiated. After administering CyA, she developed discomfort and almost intolerable pain in both legs. She was diagnosed with CIPS, and her symptoms improved with cessation of CyA. The late diagnosis of CIPS can cause depression owing to psychological distress and a decrease in ADL (activities of daily living) s owing to pain. Most current reports of CIPS result from the use of CyA after organ transplantation; however, the possibility of occurrences in other contexts should also be known."}]},"item_10001_textarea_6":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"　CIPS（Calcineurin-inhibitor Induced Pain Syndrome）とはカルシニューリン阻害薬を使用中に下肢を中心とした部位に疼痛または掻痒感が生じる症候群である．今回，我々は再生不良性貧血の免疫抑制療法中に生じたCIPS の２例を経験したので報告する．１症例目は，60歳代の女性．近医にて汎血球減少を認め，当院紹介．再生不良性貧血（Stage4）と診断し，ATG（antithymocyteglobulin）/CyA（Cyclosporin A）併用療法を開始した．CyA 投与後，両側下肢の違和感・耐え難い疼痛を発症した．CIPS と診断し，CyA 中止にて症状改善した．その後，再生不良性貧血の増悪に対し低用量でCyA を再開．これによりCIPS が再発し，うつ症状の増強により治療継続が困難となり，原疾患悪化のため死亡した．２症例目は，60歳代の女性．貧血および血小板減少を認めたため，当院紹介．再生不良性貧血（Stage2）と診断し，CyA 療法を開始した．CyA 投与後，両側下肢の違和感・耐え難い疼痛を発症した．CIPS と診断し，CyA 中止にて症状改善した．CIPSは診断が遅れた場合，疼痛に伴うADL（activities of daily living）の低下や精神的苦痛によるうつ症状をきたすことがある．現在CIPS の報告は，臓器移植後にCyA を使用したものがほとんどであるが，それ以外でも発症する可能性があることを知っておくべきと考えられた．"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"内田, 圭一","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"佐野, 史典","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"林, 成樹","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"近藤, 英生","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"和田, 秀穂","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"UCHIDA, Keiichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SANO, Fuminori","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HAYASHI, Shigeki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KONDO, Eisei","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"WADA, Hideho","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-04-01"}],"displaytype":"detail","filename":"KMJ-J201945089.pdf","filesize":[{"value":"1.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PDF","objectType":"fulltext","url":"https://kwmed.repo.nii.ac.jp/record/2176/files/KMJ-J201945089.pdf"},"version_id":"c3beb43e-9335-4e72-9e63-9c291172259f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"CIPS","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"カルシニューリン阻害剤","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"再生不良性貧血","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"CIPS","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Calcineurin-inhibitor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Aplastic anemia","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"再生不良性貧血治療中にカルシニューリン阻害薬誘発性疼痛症候群を発症した２例","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"再生不良性貧血治療中にカルシニューリン阻害薬誘発性疼痛症候群を発症した２例","subitem_title_language":"ja"},{"subitem_title":"Two cases of calcineurin inhibitor-induced pain syndrome during treatment for aplastic anemia","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"31","path":["686"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-04-01"},"publish_date":"2020-04-01","publish_status":"0","recid":"2176","relation_version_is_last":true,"title":["再生不良性貧血治療中にカルシニューリン阻害薬誘発性疼痛症候群を発症した２例"],"weko_creator_id":"31","weko_shared_id":-1},"updated":"2024-04-19T04:11:14.227739+00:00"}