{"created":"2023-06-19T10:30:05.609511+00:00","id":2183,"links":{},"metadata":{"_buckets":{"deposit":"dfa2a7d9-ba04-4c42-a080-3173d962045f"},"_deposit":{"created_by":31,"id":"2183","owners":[31],"pid":{"revision_id":0,"type":"depid","value":"2183"},"status":"published"},"_oai":{"id":"oai:kwmed.repo.nii.ac.jp:00002183","sets":["1709617079800:35:686"]},"author_link":["109877","109878","109879","109880","109881","109882","109883","109884","109885","109886","109887","109888","109889","109890","109891","109892"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"153","bibliographicPageStart":"147","bibliographicVolumeNumber":"45","bibliographic_titles":[{"bibliographic_title":"川崎医学会誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Kawasaki medical journal","bibliographic_titleLang":"en"}]}]},"item_10001_description_33":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"症例報告","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10001_description_34":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Case Report","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"川崎医学会","subitem_publisher_language":"ja"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11482/KMJ-J201945147","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://igakkai.kms-igakkai.com/wp/wp-content/uploads/2019/KMJ-J201945147.pdf","subitem_relation_type_select":"URI"}}]},"item_10001_relation_35":{"attribute_name":"医中誌ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"2020200388","subitem_relation_type_select":"ICHUSHI"}}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00045593","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AN12940574","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0386-5924","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"2758-089X","subitem_source_identifier_type":"EISSN"}]},"item_10001_text_31":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学脳神経外科学１"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学脳神経外科学１"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学脳神経外科学１"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学脳神経外科学１"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学脳神経外科学１"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学脳神経外科学１"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学脳神経外科学１"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学脳神経外科学１"}]},"item_10001_text_32":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Neurosurgery1, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Neurosurgery1, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Neurosurgery1, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Neurosurgery1, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Neurosurgery1, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Neurosurgery1, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Neurosurgery1, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Neurosurgery1, Kawasaki Medical School"}]},"item_10001_textarea_5":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"　The incidence of leptomeningeal carcinomatosis is increasing with the extension of the survival because of the advances in cancer treatment. This condition significantly deteriorates the patients' quality of life (QOL) and worsens the prognosis. Because the reduction of neurological symptoms can be expected to improve the QOL, it is necessary to reexamine the indications for surgical treatment of leptomeningeal carcinomatosis. We report three cases of surgically treated leptomeningeal carcinomatosis, and we review the literature, including past cases, with regard to the indications for surgical treatment.\n　Case 1: A 56-year-old man was diagnosed with leptomeningeal carcinomatosis with multiple brain metastases from lung cancer. Whole-brain irradiation was performed, followed by systemic chemotherapy, which was discontinued because of the development of a consciousness disorder. As the patient’s performance status (PS) improved after ventricular drainage, ventriculoperitoneal (VP) shunt was performed. Postoperatively, the consciousness disorder improved, and treatment was restarted. The patient’s PS and QOL improved; he was able to live a relatively good daily life. However, he died 3 months after the surgery because of deterioration of his general condition resulting from the side effects of nivolumab.\n　Case 2: A 55-year-old woman diagnosed with lung adenocarcinoma complained of headaches. She was diagnosed with leptomeningeal carcinomatosis and underwent systemic chemotherapy, including epidermal growth factor receptor tyrosine kinase inhibitors. Her symptoms initially improved; however, after a while, the headaches and nausea worsened and her PS deteriorated. The ventricular drainage improved her PS; therefore, VP shunt was performed. Postoperatively, her PS and QOL improved and she was switched to palliative care as the nausea and pain became controllable. However, she died because of deterioration of her general condition 4 months after the surgery.\n　Case 3: A 66-year-old woman complaining of headaches was diagnosed with leptomeningeal carcinomatosis associated with lung cancer. Because pain control was difficult and her PS was reduced, ventricular drainage was performed. Postoperatively, pain control became possible and her PS improved. Although treatment with erlotinib was started, the patient could not undergo VP shunt because of deterioration of her general condition resulting from an interstitial pneumonia, and she died 44 days after the ventricular drainage."}]},"item_10001_textarea_6":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"　髄膜癌腫症は，がんの集学的治療の進歩による生存期間の延長に伴い，診断される機会も増加している．髄膜癌腫症は患者のQuality of life(QOL) を著しく低下させ，生命予後に直結することが多い．神経症状の軽減によるQOL の改善を考えると，髄膜癌腫症に対する外科治療の介入を検討し直す必要があると思われる．\n　我々は，髄膜癌腫症に対し外科治療を施行した３症例経験した．外科治療の適応に関し，過去の症例も交え，文献的考察を加え報告する．\n　【症例１】56歳男性．肺癌を原発とする多発脳転移を伴う髄膜癌腫症と診断された．全脳照射後に全身化学療法を行うも，意識障害をきたし，全身化学療法の継続が困難となった．髄液排除によりPerformance Status（PS）が改善したため，脳室腹腔短絡術を施行した．術後，意識障害は改善し，治療を再開した．PS は改善し，比較的良好な日常生活を送れQOL は改善したと考えられたが，Nivolumab の副作用により，全身状態は悪化し，術後３か月で死亡した．\n　【症例２】55歳女性．肺腺癌と診断され，頭痛が出現し，髄膜癌腫症と診断された．EGFR-TKIを含む全身化学療法を行い，症状は改善傾向であった．その後，頭痛，嘔気が増悪しPS は低下した．脳室ドレナージ術により，PS は改善し，嘔気・疼痛のコントロールが可能となったため，脳室腹腔短絡術を施行した．術後，緩和医療に移行し，残された時間を有意義に過ごすことができ，QOL は改善したと考えられたが，全身状態の悪化により術後４か月で死亡した．\n　【症例３】66歳女性．頭痛が出現し，肺癌に伴う，髄膜癌腫症と診断された．疼痛コントロールが困難であり，PS も低下していたため，脳室ドレナージ術を施行したところ，疼痛コントロールが可能となった．PS の改善に伴い，Erlotinib による治療を開始することができた．しかし，間質性肺炎による全身状態の悪化により，脳室腹腔短絡術は施行できず，脳室ドレナージ術から44日で死亡した．"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田尾, 良文","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"原, 慶次郎","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"木下, 景太","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"平井, 聡","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"高井, 洋樹","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"八木, 謙次","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"松原, 俊二","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"宇野, 昌明","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAO, Yoshifumi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HARA, Keijiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KINOSHITA, Keita","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HIRAI, Satoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAKAI, Hiroki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YAGI, Kenji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MATSUBARA, Shunji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"UNO, Masaaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-04-01"}],"displaytype":"detail","filename":"KMJ-J201945147.pdf","filesize":[{"value":"2.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PDF","objectType":"fulltext","url":"https://kwmed.repo.nii.ac.jp/record/2183/files/KMJ-J201945147.pdf"},"version_id":"aa93afd4-2596-4141-9038-9cd611d25bed"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"髄膜癌腫症","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"脳室腹腔短絡術","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"脳室ドレナージ術","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Leptomeningeal carcinomatosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Ventriculoperitoneal shunt","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Ventricular drainage","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"髄膜癌腫症による頭蓋内圧亢進症に対する脳室腹腔短絡術の有用性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"髄膜癌腫症による頭蓋内圧亢進症に対する脳室腹腔短絡術の有用性","subitem_title_language":"ja"},{"subitem_title":"Usefulness of ventriculoperitoneal shunt for symptoms of increased intracranial pressure due to leptomeningeal carcinomatosis","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"31","path":["686"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-04-01"},"publish_date":"2020-04-01","publish_status":"0","recid":"2183","relation_version_is_last":true,"title":["髄膜癌腫症による頭蓋内圧亢進症に対する脳室腹腔短絡術の有用性"],"weko_creator_id":"31","weko_shared_id":-1},"updated":"2024-04-19T04:11:27.141992+00:00"}