{"created":"2023-06-19T10:30:05.886822+00:00","id":2187,"links":{},"metadata":{"_buckets":{"deposit":"4f47e71f-102e-4cb0-ade1-ea7d5d7d94da"},"_deposit":{"created_by":3,"id":"2187","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2187"},"status":"published"},"_oai":{"id":"oai:kwmed.repo.nii.ac.jp:00002187","sets":["1709617079800:37:687"]},"author_link":["125030","125029","125032","125028","125027","125026","125031","125033"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"25","bibliographicPageStart":"15","bibliographicVolumeNumber":"45","bibliographic_titles":[{},{"bibliographic_title":"Kawasaki medical journal","bibliographic_titleLang":"en"}]}]},"item_10001_description_34":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Regular Article","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Kawasaki Medical Society"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11482/KMJ-E201945015","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://igakkai.kms-igakkai.com/wp/wp-content/uploads/2019en/KMJ-E201945015.pdf","subitem_relation_type_select":"URI"}}]},"item_10001_relation_35":{"attribute_name":"医中誌ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"2020354374","subitem_relation_type_select":"ICHUSHI"}}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12685295","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12029005","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03850234","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"24343404","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_32":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Division of Gastroenterology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Division of Gastroenterology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Division of Gastroenterology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Division of Gastroenterology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Gastroenterology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Gastroenterology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Gastroenterology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Gastroenterology, Kawasaki Medical School"}]},"item_10001_textarea_5":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"　Background: 5-HT4 agonists (mosapride) and acetylcholine esterase inhibitor (acotiamide) are prokinetics used to treat functional dyspepsia (FD). However, to date, there has been no direct comparative study between them. The aim of this study was to compare the drugs’ efficacy and safety and to determine their predictive biomarkers.\n　Methods: The present study was a prospective, randomized, open-labeled, and crossover trial in Japanese FD patients. FD was diagnosed using Rome IV. We performed upper gastrointestinal (GI) endoscopy, GI symptom rating scale, and 8-item Short-Form Health Survey to evaluate the presence of GI disorders, GI symptoms, and quality of life (QOL), respectively. Responders were defined when reporting at least a 40% improvement of the GSRS scores from their baseline.\n　Results: In total, 60 Japanese FD patients were randomly assigned to the acotiamide preceding group (n = 30) or mosapride preceding group (n = 30), and 51 patients were finally analyzed. Following treatment with both mosapride and acotiamide, GI symptoms and QOL scores improved significantly. The responder rates of mosapride and acotiamide were 37% and 33%, respectively. No severe adverse clinical event developed. The prevalence of H. pylori eradication history was significantly lower in the mosapride responder group than in the nonresponder group (45.9% vs. 14.2%, p = 0.03).\n　Discussion: Mosapride and acotiamide had similar effects on GI symptoms in FD patients in the absence of severe adverse events. H. pylori infection might impact in the pathogenesis of functional dyspepsia. Further investigation is needed to clarify the difference between mosapride and acotiamide."}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"KATSUMATA, Ryo","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HANDA, Yukiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"GOUDA, Kyousuke","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"FUKUSHIMA, Shinya","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ISHII, Manabu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MURAO, Takahisa","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MATSUMOTO, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SHIOTANI, Akiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-04-01"}],"displaytype":"detail","filename":"KMJ-E201945015.pdf","filesize":[{"value":"939.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PDF","url":"https://kwmed.repo.nii.ac.jp/record/2187/files/KMJ-E201945015.pdf"},"version_id":"98cdef79-030f-4755-9fdf-24bd6da4fd90"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Functional Dyspepsia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Mosapride","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Acotiami","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Comparison of Efficacy and Safety between Mosapride and Acotiamide for Japanese patients with Functional Dyspepsia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Comparison of Efficacy and Safety between Mosapride and Acotiamide for Japanese patients with Functional Dyspepsia","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"3","path":["687"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-01"},"publish_date":"2020-04-01","publish_status":"0","recid":"2187","relation_version_is_last":true,"title":["Comparison of Efficacy and Safety between Mosapride and Acotiamide for Japanese patients with Functional Dyspepsia"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T11:08:43.151960+00:00"}