{"created":"2023-06-19T10:30:46.427397+00:00","id":2914,"links":{},"metadata":{"_buckets":{"deposit":"445c7846-e44f-47bf-ab7a-052113ac3b75"},"_deposit":{"created_by":31,"id":"2914","owners":[31],"pid":{"revision_id":0,"type":"depid","value":"2914"},"status":"published"},"_oai":{"id":"oai:kwmed.repo.nii.ac.jp:00002914","sets":["1709617079800:35:791"]},"author_link":["110033","110034","110035","110036","110037","110038","110039","110040","110041","110042","110043","110044","110045","110046","110047","110048","110049","110050","110051","110052","110053","110054"],"item_10001_alternative_title_1":{"attribute_name":"その他(別言語等)のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Combination of shear-wave elastography and liver fibrosis markers predicts severe fibrosis in patients with non-alcoholic steatohepatitis","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"64","bibliographicPageStart":"55","bibliographicVolumeNumber":"46","bibliographic_titles":[{"bibliographic_title":"川崎医学会誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Kawasaki medical journal","bibliographic_titleLang":"en"}]}]},"item_10001_description_33":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著論文","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10001_description_34":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Regular Article","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"川崎医学会","subitem_publisher_language":"ja"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11482/KMJ-J202046055","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://igakkai.kms-igakkai.com/wp/wp-content/uploads/2020/KMJ-J202046055.pdf","subitem_relation_type_select":"URI"}}]},"item_10001_relation_35":{"attribute_name":"医中誌ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"2021178671","subitem_relation_type_select":"ICHUSHI"}}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00045593","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12940574","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03865924","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"2758089X","subitem_source_identifier_type":"EISSN"}]},"item_10001_text_31":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学総合内科学２"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学総合内科学２"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学総合内科学２"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学総合内科学２"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学総合内科学２"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学総合内科学２"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学総合内科学２"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学総合内科学２"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学検査診断学（内視鏡・超音波）"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学検査診断学（内視鏡・超音波）"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学総合内科学２"},{"subitem_text_language":"ja"}]},"item_10001_text_32":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of General Internal Medicine2, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of General Internal Medicine2, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of General Internal Medicine2, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of General Internal Medicine2, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of General Internal Medicine2, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of General Internal Medicine2, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of General Internal Medicine2, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of General Internal Medicine2, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Endoscopy and Ultrasound, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Endoscopy and Ultrasound, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of General Internal Medicine2, Kawasaki Medical School"}]},"item_10001_textarea_5":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"　In the recent years, the incidence of nonalcoholic fatty liver disease (NAFLD) is increasing rapidly worldwide. It is important to detect nonalcoholic steatohepatitis (NASH) with a poor prognosis in patients with NAFLD using noninvasive diagnostic methods. Conventional ultrasound (US) is the most common, low-cost technique for NASH diagnosis and improving patient prognosis. We studied the usefulness of US elastography (shear-wave elastography [SWE]) in diagnosing liver fibrosis (LF) with NAFLD and examined the possibility of improving the diagnosis of patients with advanced LF by combining SWE and LF-marker testing. The subjects were 140 patients with NAFLD who underwent liver biopsies, SWE, and LF-marker tests, such as type IV collagen 7S, Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA[+]-M2BP), P-Ⅲ-P, hyaluronic acid, and fibrosis-4 (FIB4) index, at the General Medical Center, Kawasaki Medical School. We evaluated the efficacy of combined SWE and LF-marker tests to diagnose advanced LF (stage ≥3). SWE was performed using 3.75-MHz probes (Canon Aplio 500, JAPAN). There were minimal differences in LF-marker levels for NASH stages 0–2, whereas significantly increased LF-marker levels were observed in patients with advanced LF (stages 3 and 4). SWE showed significantly elevated LF-marker levels at stage 2 compared with stages 0–1, and NASH was detected earlier than other LF markers. The areas under the receiver-operating characteristic curves (AUCs) for SWE, type IV collagen 7S, WFA(+)-M2BP, P-Ⅲ-P, hyaluronic acid, and FIB4 index for stage ≥3 were 0.86, 0.83, 0.79, 0.75, 0.75, and 0.77, respectively. With combined SWE and LF markers, the AUCs increased to 0.92, 0.88, 0.86, 0.88, and 0.88, respectively, showing increased diagnostic ability compared to that of single markers. The diagnostic ability of combined SWE and type IV collagen 7S was superior to that of other combinations. In addition, we detected that most cases were in stage ≥3 on combining SWE and LF markers. SWE for NASH can simply diagnose LF progression; the diagnostic capacity of SWE for LF improves in combination with LF-marker tests. It may be possible to detect the need for liver biopsy and treatment or follow-up, as well as reduce the number of liver biopsies by identifying NAFLD with low LF levels."}]},"item_10001_textarea_6":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"　非アルコール性脂肪性肝疾患（Non-alcoholic fatty liver disease：NAFLD）の中から予後の悪い線維化が進展した非アルコール性脂肪肝炎（Non-alcoholic steatohepatitis：NASH）を非侵襲的診断法にて拾い上げることが重要である．今回，バイオマーカーやshear wave elastography（以下 SWE）を組み合わせた非侵襲的診断における肝線維化進展症例の診断能の向上について検討を行った．肝生検および SWE を施行し，肝線維化マーカーを測定した NAFLD 患者140名を対象とし，SWE 値と肝線維化マーカーの測定を行い線維化進展例（stage3以上）の診断の拾い上げについて検討した．各種線維化マーカーは stage3-4の線維化進展例で有意に上昇を認め，SWE においてはstage2の段階から上昇し，他の線維化マーカーより早い段階から NASH の線維化の診断ができた．SWE，Ⅳ型コラーゲン7S，WFA+M2BP，P-Ⅲ-P，ヒアルロン酸，FIB4 index における stage3以上の AUC はそれぞれ0.86，0.83，0.79，0.75，0.75，0.77であった．さらに SWE と線維化マーカーを組み合わせたところ，AUC はそれぞれ0.92，0.88，0.86，0.88，0.88で診断能の上昇を認めた．特に SWE とⅣ型コラーゲン7S の診断能が最も優れていた．NASH における SWE は簡便に線維化進展の診断が可能であり，バイオマーカーを組み合わせることで肝線維化診断能が上昇した．以上より線維化の軽度な NASH 症例や非アルコール性脂肪肝（Non-alcoholic fatty liver：NAFL）を識別し，肝生検を減少させる可能性があり，NAFLD の予後の改善に繋がると思われた．"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"浦田, 矩代","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"川中, 美和","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"石井, 克憲","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"谷川, 朋弘","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"西野, 謙","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"末廣, 満彦","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"笹井, 貴子","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"春間, 賢","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"中村, 純","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"眞部, 紀明","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"河本, 博文","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"URATA, Noriyo","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KAWANAKA, Miwa","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ISHII, Katsunori","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TANIKAWA, Tomohiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NISHINO, Ken","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SUEHIRO, Mitsuhiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SASAI, Takako","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HARUMA, Ken","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NAKAMURA, Jun","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MANABE, Noriaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KAWAMOTO, Hirofumi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-10-18"}],"displaytype":"detail","filename":"KMJ-J202046055.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PDF","objectType":"fulltext","url":"https://kwmed.repo.nii.ac.jp/record/2914/files/KMJ-J202046055.pdf"},"version_id":"bd65aa90-6ee1-4ce9-8636-c74d1ca52c60"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":" Non-alcoholic fatty liver disease（NAFLD）","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"肝線維化","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Shear wave elastography（SWE）","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"FIB4 index","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Ⅳ型コラーゲン7S","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Non-alcoholic fatty liver disease (NAFLD)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Advanced liver fibrosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Shear wave elastography (SWE)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"FIB4 index","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"TypeⅣ collagen7S","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"非アルコール性脂肪性肝疾患におけるShear Wave Elastography（SWE）と肝線維化マーカーの組み合わせによる肝線維化診断の予測の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"非アルコール性脂肪性肝疾患におけるShear Wave Elastography（SWE）と肝線維化マーカーの組み合わせによる肝線維化診断の予測の検討","subitem_title_language":"ja"}]},"item_type_id":"10001","owner":"31","path":["791"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-10-18"},"publish_date":"2022-10-18","publish_status":"0","recid":"2914","relation_version_is_last":true,"title":["非アルコール性脂肪性肝疾患におけるShear Wave Elastography（SWE）と肝線維化マーカーの組み合わせによる肝線維化診断の予測の検討"],"weko_creator_id":"31","weko_shared_id":-1},"updated":"2024-04-12T06:50:23.333990+00:00"}