{"created":"2023-06-19T10:30:46.475197+00:00","id":2915,"links":{},"metadata":{"_buckets":{"deposit":"a570dd7b-39b6-44fa-9f5b-15c178a14ddd"},"_deposit":{"created_by":31,"id":"2915","owners":[31],"pid":{"revision_id":0,"type":"depid","value":"2915"},"status":"published"},"_oai":{"id":"oai:kwmed.repo.nii.ac.jp:00002915","sets":["1709617079800:35:791"]},"author_link":["110055","110056","110057","110058","110059","110060","110061","110062","110063","110064","110065","110066","110067","110068"],"item_10001_alternative_title_1":{"attribute_name":"その他(別言語等)のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"The angiogenesis and functional recovery effect after spinal cord injury by newly synthesized nucleotide analog, COA-Cl","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"72","bibliographicPageStart":"65","bibliographicVolumeNumber":"46","bibliographic_titles":[{"bibliographic_title":"川崎医学会誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Kawasaki medical journal","bibliographic_titleLang":"en"}]}]},"item_10001_description_33":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著論文","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10001_description_34":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Regular Article","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"川崎医学会","subitem_publisher_language":"ja"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11482/KMJ-J202046065","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://igakkai.kms-igakkai.com/wp/wp-content/uploads/2020/KMJ-J202046065.pdf","subitem_relation_type_select":"URI"}}]},"item_10001_relation_35":{"attribute_name":"医中誌ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"2021178672","subitem_relation_type_select":"ICHUSHI"}}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00045593","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12940574","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03865924","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"2758089X","subitem_source_identifier_type":"EISSN"}]},"item_10001_text_31":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学生理学２・川崎医科大学脊椎・災害整形外科学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学生理学２"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学生理学２"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学生理学２"},{"subitem_text_language":"ja","subitem_text_value":"聖隷淡路病院"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学脊椎・災害整形外科学・聖隷淡路病院"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学生理学２"}]},"item_10001_text_32":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Physiology 2, Kawasaki Medical School・Department of Orthopedics, Traumatology and Spine Surgery, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Physiology 2, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Physiology 2, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Physiology 2, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Seirei Awaji Hospital"},{"subitem_text_language":"en","subitem_text_value":"Department of Orthopedics, Traumatology and Spine Surgery, Kawasaki Medical School・Seirei Awaji Hospital"},{"subitem_text_language":"en","subitem_text_value":"Department of Physiology 2, Kawasaki Medical School"}]},"item_10001_textarea_5":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"　2-chloro-carbocyclic oxetanocin A (COA-Cl), a novel synthesized adenosine analog, has been reported to have a strong angiogenic effect. In our previous study using a rat model of stroke, we showed the neuroprotective, angiogenic and motor recovery effects of COACl. Spinal cord injury (SCI) induces severe motor dysfunction and lowers the quality of life. In our recent study, we demonstrated that acute-phase administration of COA-Cl protects against spinal cord damage and facilitates motor recovery after SCI. In this study, we hypothesized that acute-phase administration of COA-Cl post-SCI also induces early neovascularization and participates in motor function recovery. SCI was induced using a drop device in rats. Rats with SCI were divided into 2 groups: COA-Cl and vehicle groups (n = 5 in each group). COACl was intraperitoneally injected (6 mg/kg in saline) once a day for 5 days immediately after SCI. In the vehicle group, only saline was administered, with the same dosing regimen as that in the COA-Cl group. Fourteen days after SCI, motor function was evaluated based on Basso–Beattie–Bresnahan scoring and the inclined plane test. To evaluate angiogenesis, cryosections of the spinal cord were immunostained with anti-laminin antibody. Motor function significantly improved in the COA-Cl group compared with that in the vehicle group; concomitantly, both the number and volume of blood vessels significantly increased in the COA-Cl group compared with those in the vehicle group. In conclusion, acute-phase administration of COA-Cl results in motor function recovery, which may be attributed to angiogenic effects."}]},"item_10001_textarea_6":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"　2-chloro-carbocyclic oxetanocin A（COA-Cl）はアデノシン類似体合成化合物であり in vitro にて血管新生作用が報告されており，またラットの脳卒中モデルに対する投与で神経保護，血管新生および機能回復効果が示されている．本研究ではこれらの効果が脊髄損傷モデルにおいても発揮されるか否かを評価した．荷重装置により T9レベルの脊髄損傷モデルラットを作製し，損傷直後から COA-Cl を５日間腹腔内投与した COA-Cl 群と，同量の生理食塩水を投与した vehicle群に分けた．脊髄損傷14日後に運動機能を Basso-Beattie-Bresnahan Locomotor Rating Scale スコア（BBB スコア）と傾斜台試験にて，血管新生をラミニンの免疫染色により後索の血管数と血管面積を測定することで評価した．運動機能は BBB スコアと傾斜台試験ともに COA-Cl 群でvehicle 群に比べて有意に改善した．血管新生は COA-Cl 群で血管数および血管面積ともに有意に増加した．これらの結果から，COA-Cl の脊髄損傷後急性期における投与は運動機能改善および血管新生をもたらし，脊髄損傷急性期の新規治療薬としての可能性が示された．"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"坂本, 一晴","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"110055","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"氷見, 直之","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"110056","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中村-丸山, 恵美","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"110057","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"萩原, 喜美子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"110058","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"林, 範人","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"110059","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長谷川, 徹","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"110060","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"宮本, 修","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"110061","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"SAKAMOTO, Issei","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"110062","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HIMI, Naoyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"110063","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"NAKAMURA-MARUYAMA, Emi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"110064","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HAGIHARA, Kimiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"110065","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HAYASHI, Norito","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"110066","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HASEGAWA, Toru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"110067","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"MIYAMOTO, Osamu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"110068","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-10-18"}],"displaytype":"detail","filename":"KMJ-J202046065.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PDF","objectType":"fulltext","url":"https://kwmed.repo.nii.ac.jp/record/2915/files/KMJ-J202046065.pdf"},"version_id":"89283ffa-7bc1-4e71-995e-77e0a484efd7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"COA-Cl","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"血管新生","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"脊髄損傷","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"機能回復促進","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"COA-Cl","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Angiogenesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Spinal cord injury","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Motor functional recovery","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"新規核酸アナログ COA-Cl による脊髄損傷後の血管新生および機能回復効果","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新規核酸アナログ COA-Cl による脊髄損傷後の血管新生および機能回復効果","subitem_title_language":"ja"}]},"item_type_id":"10001","owner":"31","path":["791"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-10-18"},"publish_date":"2022-10-18","publish_status":"0","recid":"2915","relation_version_is_last":true,"title":["新規核酸アナログ COA-Cl による脊髄損傷後の血管新生および機能回復効果"],"weko_creator_id":"31","weko_shared_id":-1},"updated":"2024-04-12T06:50:24.890772+00:00"}