{"created":"2023-06-19T10:30:50.853423+00:00","id":2998,"links":{},"metadata":{"_buckets":{"deposit":"764488b2-7010-4e1a-807a-37cce14f40b4"},"_deposit":{"created_by":31,"id":"2998","owners":[31],"pid":{"revision_id":0,"type":"depid","value":"2998"},"status":"published"},"_oai":{"id":"oai:kwmed.repo.nii.ac.jp:00002998","sets":["1709617079800:35:800"]},"author_link":["130859","130860","130861","130862","130863","130864","130865","130866","130867","130868","130869","130870","130871","130872","130873","130874","130875","130876","130877","130878","130879","130880","130881","130882"],"item_10001_alternative_title_1":{"attribute_name":"その他(別言語等)のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Retrospective study evaluating myeloablative conditioning containing total body irradiation of 12 Gy/4 fractions/4 days for acute lymphoblastic leukemia","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"146","bibliographicPageStart":"139","bibliographicVolumeNumber":"47","bibliographic_titles":[{"bibliographic_title":"川崎医学会誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Kawasaki medical journal","bibliographic_titleLang":"en"}]}]},"item_10001_description_33":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著論文","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10001_description_34":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Regular Article","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"川崎医学会","subitem_publisher_language":"ja"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11482/KMJ-J202147139","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://igakkai.kms-igakkai.com/wp/wp-content/uploads/2021/KMJ-J202147139.pdf","subitem_relation_type_select":"URI"}}]},"item_10001_relation_35":{"attribute_name":"医中誌ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"2022194423","subitem_relation_type_select":"ICHUSHI"}}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00045593","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AN12940574","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0386-5924","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"2758-089X","subitem_source_identifier_type":"EISSN"}]},"item_10001_text_31":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学放射線腫瘍学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学放射線腫瘍学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学血液内科学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学放射線腫瘍学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学放射線腫瘍学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学放射線腫瘍学"},{"subitem_text_language":"ja","subitem_text_value":"川崎附属病院中央放射線部"},{"subitem_text_language":"ja","subitem_text_value":"川崎附属病院中央放射線部"},{"subitem_text_language":"ja","subitem_text_value":"川崎附属病院中央放射線部"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学血液内科学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学血液内科学"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学血液内科学"}]},"item_10001_text_32":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Radiation Oncology"},{"subitem_text_language":"en","subitem_text_value":"Department of Radiation Oncology"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Radiation Oncology"},{"subitem_text_language":"en","subitem_text_value":"Department of Radiation Oncology"},{"subitem_text_language":"en","subitem_text_value":"Department of Radiation Oncology"},{"subitem_text_language":"en","subitem_text_value":" Department of Central Radiation Center, Kawasaki Medical School Hospital"},{"subitem_text_language":"en","subitem_text_value":" Department of Central Radiation Center, Kawasaki Medical School Hospital"},{"subitem_text_language":"en","subitem_text_value":" Department of Central Radiation Center, Kawasaki Medical School Hospital"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Hematology, Kawasaki Medical School"}]},"item_10001_textarea_5":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"　This study aimed to clarify the outcomes of hematopoietic stem cell transplantation after myeloablative conditioning with a total-body irradiation regimen of 12 Gy/4 fractions/4 days in patients with acute lymphoblastic lymphoma. We retrospectively investigated transplantation outcomes and late adverse events, including radiation pneumonitis, in 14 patients (age range: 16–50 years) who underwent myeloablative conditioning prior to hematopoietic stem cell transplantation between May 2007 and November 2016. The median observation period was 73 months; the neutrophil engraftment rate was 85.7%; and the 5-year disease-free survival rate was 64.3%. Among the 14 patients, six died due to transplantationrelated adverse events, and eight survived to the last follow-up. The outcomes of hematopoietic stem cell transplantation after the prespecified myeloablative conditioning regimen for smoothly implementing LINAC-based total-body irradiation and reducing the burden on the staff were equivalent to the outcomes with a previously reported myeloablative regimen of 12 Gy/6 fractions/3 days, which is frequently used in Japan. Despite hypofractionated irradiation, the incidence of late adverse events was low, and radiation pneumonitis did not occur. Myeloablative conditioning prior to hematopoietic stem cell transplantation was performed safely using a regimen of 12 Gy/4 fractions/4 days."}]},"item_10001_textarea_6":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"　目的は急性リンパ性白血病に対し，12Gy/4分割 /4日の全身放射線照射（total-body irradiation: TBI）を用い骨髄破壊的前処置を行った造血幹細胞移植（hematopoietic stem cell transplantation: HSCT）の成績を明らかにすることである．2007年５月から2016年11月に上記の 移植前処置を用いて HSCT を行った16～50歳の患者14例を対象に，移植成績と放射線肺臓炎を含む晩期有害事象について後方視的に検討した．観察期間中央値は73ヵ月，好中球生着率85.7％，５ 年無病生存率64.3％であった．14例中６例が移植関連の有害事象で死亡，８例は生存中である．リ ニアックの円滑利用やスタッフの負担軽減を目的とした12Gy/4分割 /4日での TBI を用いた HSCT の移植成績は，我が国で頻用される12Gy/6分割 /3日の既報と同等であり，寡分割照射にも関わらず放射線肺臓炎の合併はなく，他の晩期有害事象の合併も少なく，安全に行えていた．"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"釋舍, 竜司","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"神谷, 伸彦","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"松橋, 佳子","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"余田, 栄作","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"林, 貴史","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"河田, 裕二郎","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"樋口, 真樹子","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"角場, 幸記","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"長瀬, 尚巳","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"近藤, 敏範","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"近藤, 英生","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"和田, 秀穂","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TOKIYA, Ryouji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KAMITANI, Nobuhiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MATSUHASHI, Yoshiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YODEN, Eisaku","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HAYASHI, Takafumi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KAWATA, Yujiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HIGUCHI, Makiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KAKUBA, Kouki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NAGASE, Naomi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KONDO, Toshinori","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KONDO, Eisei","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"WADA, Hideho","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-04-01"}],"displaytype":"detail","filename":"KMJ-J202147139.pdf","filesize":[{"value":"2.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PDF","objectType":"fulltext","url":"https://kwmed.repo.nii.ac.jp/record/2998/files/KMJ-J202147139.pdf"},"version_id":"8a9317a1-907e-42db-a4a7-856b923d4080"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"造血幹細胞移植","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"全身放射線照射","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"骨髄破壊的前処置","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"放射線肺臓炎","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Hematopoietic stem cell transplantation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"LINAC-based myeloablation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Radiation pneumonitis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"急性リンパ性白血病に対する12Gy/4分割 /4日の全身放射線照射を用いた骨髄破壊的移植の後方視的検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"急性リンパ性白血病に対する12Gy/4分割 /4日の全身放射線照射を用いた骨髄破壊的移植の後方視的検討","subitem_title_language":"ja"}]},"item_type_id":"10001","owner":"31","path":["800"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-04-01"},"publish_date":"2022-04-01","publish_status":"0","recid":"2998","relation_version_is_last":true,"title":["急性リンパ性白血病に対する12Gy/4分割 /4日の全身放射線照射を用いた骨髄破壊的移植の後方視的検討"],"weko_creator_id":"31","weko_shared_id":-1},"updated":"2024-04-19T04:22:33.267107+00:00"}