{"created":"2023-06-19T10:30:51.339907+00:00","id":3005,"links":{},"metadata":{"_buckets":{"deposit":"de664053-1d25-4c00-9454-301fd374c9ce"},"_deposit":{"created_by":3,"id":"3005","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3005"},"status":"published"},"_oai":{"id":"oai:kwmed.repo.nii.ac.jp:00003005","sets":["1709617079800:37:801"]},"author_link":["130970","130979","130973","130975","130966","130976","130967","130977","130971","130972","130974","130969","130968","130978"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"54","bibliographicPageStart":"47","bibliographicVolumeNumber":"47","bibliographic_titles":[{},{"bibliographic_title":"Kawasaki medical journal","bibliographic_titleLang":"en"}]}]},"item_10001_description_34":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Regular Article","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Kawasaki Medical Society"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11482/KMJ-E202147047","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://igakkai.kms-igakkai.com/wp/wp-content/uploads/2021en/KMJ-E202147047.pdf","subitem_relation_type_select":"URI"}}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12685295","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12029005","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03850234","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"24343404","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_32":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of General Surgery, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of General Surgery, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"General Medical Center Research Unit, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of General Surgery, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of General Surgery, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of General Surgery, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"General Medical Center Research Unit, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of General Surgery, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of General Surgery, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"SBI Pharmaceuticals Co., Ltd."},{"subitem_text_language":"en","subitem_text_value":"SBI Pharmaceuticals Co., Ltd."},{"subitem_text_language":"en","subitem_text_value":"Department of Anesthesiology & Intensive Care Medicine 3, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Anesthesiology & Intensive Care Medicine 3, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of General Surgery, Kawasaki Medical School"}]},"item_10001_textarea_5":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"　An effective anti-cancer chemotherapy regimen can cause adverse events such as antineoplastic drug-induced oxidative stress in tissues. When hemeoxygenase-1 (HO1) is induced in tissues under oxidative stress, a tissue protective effect is observed. The non-proteinogenic amino acid 5-aminolevulinic acid (5-ALA) induces HO-1 in normal tissue and is hypothesized to provide an intestinal epithelial protective effect against drug-induced gastrointestinal mucosal disorders such as diarrhea and stomatitis. To validate this hypothesis, we introduced organoid culture from mouse intestinal epithelium. Using this organoid culture system, SN-38, the active metabolite of the antineoplastic drug irinotecan which is known to induce gastrointestinal mucosal disorders, was administered with and without 5-ALA to investigate the cytotoxic and protective effects of HO-1 suppression and expression. In normal intestinal epithelial cells, HO-1 induction by 5-ALA was observed. HO-1 expression was suppressed by the administration of SN-38 in the absence of 5-ALA, but was maintained by the co-administration of 5-ALA. In the mouse intestinal organoids, the same administration of 5-ALA induced HO-1 expression. When SN-38 was administered to the organoids, a cell death signal was expressed with an oxidative stress response, but the co-administration of 5-ALA induced HO-1 expression and cell death was decreased. The induction of HO-1 expression by 5-ALA administration suppresses intestinal epithelial cell death mediated by oxidative stress caused by antineoplastic drugs and is a potential new intestinal epithelial protective therapy against drug-induced gastrointestinal mucosal injury."}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"TAKAOKA, Munenori","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ISHIDA, Naomasa","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"IWAI, Miki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TATSUTA, Yoshiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KOSAKA, Rie","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YOKOTA, Etsuko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MIYAKE, Noriko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"FUKAZAWA, Takuya","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MATSUBARA, Masaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TANAKA, Tohru","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NAKAJIMA, Motowo","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"IKEMOTO, Naoto","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OCHIAI, Yoko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YAMATSUJI, Tomoki","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-04-01"}],"displaytype":"detail","filename":"KMJ-E202147047.pdf","filesize":[{"value":"3.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PDF","url":"https://kwmed.repo.nii.ac.jp/record/3005/files/KMJ-E202147047.pdf"},"version_id":"e249aa59-5b55-41d0-a0d4-4b5ba47e489b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"5-aminolevulinic acid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Hemeoxygenese-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Oxidative stresIntestinal mucosal injury","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Chemotherapy","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A potential protective effect of 5-aminolevulinic acid against anticancer drug-induced damage to intestinal mucosa","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A potential protective effect of 5-aminolevulinic acid against anticancer drug-induced damage to intestinal mucosa","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"3","path":["801"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-04-01"},"publish_date":"2022-04-01","publish_status":"0","recid":"3005","relation_version_is_last":true,"title":["A potential protective effect of 5-aminolevulinic acid against anticancer drug-induced damage to intestinal mucosa"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T10:50:07.813550+00:00"}