{"created":"2023-06-19T10:30:51.598129+00:00","id":3010,"links":{},"metadata":{"_buckets":{"deposit":"53dcea54-b3ed-4f85-93b8-3a80852df270"},"_deposit":{"created_by":3,"id":"3010","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3010"},"status":"published"},"_oai":{"id":"oai:kwmed.repo.nii.ac.jp:00003010","sets":["1709617079800:37:801"]},"author_link":["131032","131031","131033","131030","131034"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"97","bibliographicPageStart":"85","bibliographicVolumeNumber":"47","bibliographic_titles":[{},{"bibliographic_title":"Kawasaki medical journal","bibliographic_titleLang":"en"}]}]},"item_10001_description_34":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Regular Article","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Kawasaki Medical Society"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11482/KMJ-E202147085","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://igakkai.kms-igakkai.com/wp/wp-content/uploads/2021en/KMJ-E202147085.pdf","subitem_relation_type_select":"URI"}}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12685295","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12029005","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03850234","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"24343404","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_32":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of General Thoracic Surgery, Kawasaki Medical School\n"},{"subitem_text_language":"en","subitem_text_value":"Department of General Thoracic Surgery, Kawasaki Medical School\n"},{"subitem_text_language":"en","subitem_text_value":"Department of General Thoracic Surgery, Kawasaki Medical School\n"},{"subitem_text_language":"en","subitem_text_value":"Department of General Thoracic Surgery, Kawasaki Medical School\n"},{"subitem_text_language":"en","subitem_text_value":"Department of General Thoracic Surgery, Kawasaki Medical School"}]},"item_10001_textarea_5":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"　Numerous studies have been conducted to determine the clinical significance of the ground-glass opacity and solid-components in lung adenocarcinomas, however, few biological analyses of the two components have been carried out. This study was aimed at clarifying the biological characteristics of solid components in part-solid-type and solid-type lung adenocarcinomas. Data of a total of 112 cases of cT1b/cN0M0 lung adenocarcinoma treated by surgical resection were analyzed. We compared clinicopathological characteristics and prognosis between part-solid-type and solid-type tumors. In addition, we performed immunohistochemical analysis to determine the Ki-67 labeling index (LI), programmed cell death-1 ligand 1 (PD-L1) expression status, and CD8-positive tumor-infiltrating T lymphocyte (CD8+ TIL) count for the solid component of each tumor. Five-year recurrence-free survival (RFS) risks were significantly worse for patients with solid-type tumor than for those with part-solidtype tumor (51.7% vs. 83.2%; p < 0.001). The percentages of lymphovascular invasion, lymph node metastasis, high Ki-67 LI, and high PD-L1 expression were higher in the patient group with solid-type tumors. Univariate analysis identified Ki-67 LI, PD-L1 expression status, and CD8+ TIL count were identified as predictors of RFS in the entire subject population. Separate analyses in the two groups identified only the Ki-67 LI as an independent predictor of the RFS in the group with part-solid-type tumors, whereas in the group with solid-type tumors, the PDL1 expression status and CD8+ TIL count were identified as independent predictors of the RFS. Clear differences in the biological characteristics of the solid-component were identified between part-solid-type and solid-type lung adenocarcinomas."}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"SAISHO, Shinsuke","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SHIMIZU, Katsuhiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NOJIMA, Yuji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KUROSAKI, Takeshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NAKATA, Masao","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-04-01"}],"displaytype":"detail","filename":"KMJ-E202147085.pdf","filesize":[{"value":"3.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PDF","url":"https://kwmed.repo.nii.ac.jp/record/3010/files/KMJ-E202147085.pdf"},"version_id":"83ac3304-1e0d-4b78-9bed-5d7e388a82f6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Solid-type lung adenocarcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Part-solid-type lung adenocarcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Solid component","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Ki-67","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"PD-L1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"CD8+ TIL","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The biological Characteristics of Solid Components are Different between Part-Solid-Type and Solid-Type in Lung Adenocarcinoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The biological Characteristics of Solid Components are Different between Part-Solid-Type and Solid-Type in Lung Adenocarcinoma","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"3","path":["801"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-04-01"},"publish_date":"2022-04-01","publish_status":"0","recid":"3010","relation_version_is_last":true,"title":["The biological Characteristics of Solid Components are Different between Part-Solid-Type and Solid-Type in Lung Adenocarcinoma"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T10:50:01.446440+00:00"}