{"created":"2023-06-19T10:30:53.762088+00:00","id":3045,"links":{},"metadata":{"_buckets":{"deposit":"98aa09a9-0cb6-4263-9351-a526b947185a"},"_deposit":{"created_by":3,"id":"3045","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3045"},"status":"published"},"_oai":{"id":"oai:kwmed.repo.nii.ac.jp:00003045","sets":["1709617079800:38:806"]},"author_link":["131523","131521","131520","131522"],"item_10001_alternative_title_1":{"attribute_name":"その他(別言語等)のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Hungarian Biochemists"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"14","bibliographicPageStart":"1","bibliographicVolumeNumber":"48","bibliographic_titles":[{"bibliographic_title":"川崎医学会誌. 一般教養篇"},{"bibliographic_title":"Kawasaki Igakkai shi. Liberal arts & sciences","bibliographic_titleLang":"en"}]}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"川崎医学会"}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://igakkai.kms-igakkai.com/wp/wp-content/uploads/2022ky/ippannkyouyou48)001-014.2022.pdf","subitem_relation_type_select":"URI"}}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12940585","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"27580903","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_31":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"川崎医科大学自然科学"},{"subitem_text_value":"広島大学教養教育"}]},"item_10001_text_32":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Natural Sciences, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Liberal Arts Education, Hiroshima University "}]},"item_10001_textarea_5":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"　The roots of Hungarian biochemical research go back to the early 20th century. Albert Szent-Györgyi discovered vitamin C; F. Brunó Straub discovered actin, a protein involved in muscle contraction; Gertrúd Szabolcsi proposed the concept of‘fluctuation fit’as protein-ligand interactions  all these scientists made discoveries indispensable to the later development of history of biochemistry. But while in 1937 Szent-Györgyi was awarded the Nobel Prize in Physiology or Medicine, the achievements of the other biochemists did not receive due evaluation. \n　The burial of these achievements can be ascribed to the difficult situation in which Hungary, as an Eastern European country, was placed. Geopolitically, Hungary experienced a dark period in its relationship with Nazi-Germany in the first half of the 20th century, and in the latter half of the century with the Soviet Union, the superpower which played the leading role in the East’s\nantagonism to the West.\n　This article portrays the biochemists who lived through these difficult times, with a particular focus on F. Brunó Straub. Straub was an outstanding biochemist who tried to promote research under the communist regime and contributed to the development of science of the country. The range of his activities was expanded to the politics in the years 1988 and 1989; he was then the last head of the old state, and, with the fall of the Iron Curtain, people saw the dawn of a new era for Hungary. This was a critical moment in the modern history of Hungary, of which a brief account is given in this article; also the pursuits of scientists are described here  the scientists who faithfully fulfilled their respective lives even in the hardships they suffered.\n"}]},"item_10001_textarea_6":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_textarea_value":"　ハンガリーの生化学研究のルーツは，20世紀初頭にまで遡る。ビタミンC を発見したセント＝ジェルジ，筋収縮に関わるタンパク質アクチンを発見したシュトラウブ，タンパク質－リガンド相互作用に関する「ゆらぎの適合」の概念を提示したサボルチなど，彼らの発見はどれも生化学の歴史において重要である。ところが，その功績によってノーベル医学生理学賞を受賞したセント＝ジェルジを除いて，それ以降のシュトラウブやサボルチの研究成果は，正当な評価が得られているとは言い難い。\n　こうした研究成果の埋没には，ハンガリーが東欧諸国として20世紀に歩んだ苦難の歴史が背景としてあるのだろう。地政学的にもハンガリーは，20世紀前半には破竹の勢いのあるドイツ，そして後半は共産圏の長として超大国となったソ連との関係性において暗い時代を経験した。\n　本稿では，こうした苦難の時代を過ごした生化学者を，特にシュトラウブに焦点を当てて紹介する。Ｆ・ブルノ・シュトラウブは，一人の優れた生化学者として研究成果を残した一方で，共産主義体制の中で科学の発展や国の未来のために尽力した人物である。その活動の領域は，1989年というハンガリーにとって鉄のカーテンからの夜明けを意味する年には，国家元首を務めるまで広がっていた。本稿では，ハンガリーの近代史を簡潔に振り返りながら，東欧諸国の厳しい時代や，そうした状況下でもそれぞれの道を真摯に貫いた科学者たちの軌跡をたどる。\n"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"宮野, 佳"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"本田, 蘭子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MIYANO, Kei","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HONDA, Ranko","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-10"}],"displaytype":"detail","filename":"ippannkyouyou48)001-014.2022.pdf","filesize":[{"value":"1.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PDF","url":"https://kwmed.repo.nii.ac.jp/record/3045/files/ippannkyouyou48)001-014.2022.pdf"},"version_id":"ea5d1634-68cc-4b5b-addd-8b481b318894"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ハンガリー","subitem_subject_scheme":"Other"},{"subitem_subject":"生化学","subitem_subject_scheme":"Other"},{"subitem_subject":"ブルノ・シュトラウブ","subitem_subject_scheme":"Other"},{"subitem_subject":"アルベルト・セント＝ジェルジ","subitem_subject_scheme":"Other"},{"subitem_subject":"ゲルトルート・サボルチ","subitem_subject_scheme":"Other"},{"subitem_subject":"ゆらぎの適合","subitem_subject_scheme":"Other"},{"subitem_subject":"Hungary","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"biochemistry","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"F. Brunó Straub","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Albert Szent-Györgyi","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Gertrúd Szabolcsi","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"fluctuation fit","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ハンガリーの生化学者","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ハンガリーの生化学者"}]},"item_type_id":"10001","owner":"3","path":["806"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-03-10"},"publish_date":"2023-03-10","publish_status":"0","recid":"3045","relation_version_is_last":true,"title":["ハンガリーの生化学者"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T10:49:16.701634+00:00"}