{"created":"2023-06-19T10:30:54.776493+00:00","id":3064,"links":{},"metadata":{"_buckets":{"deposit":"c4716761-ee03-4e1a-b46a-930b763cd87d"},"_deposit":{"created_by":31,"id":"3064","owners":[31],"pid":{"revision_id":0,"type":"depid","value":"3064"},"status":"published"},"_oai":{"id":"oai:kwmed.repo.nii.ac.jp:00003064","sets":["1709617079800:37:807"]},"author_link":["131791","131792","131793","131794","131795","131796"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"174","bibliographicPageStart":"169","bibliographicVolumeNumber":"48","bibliographic_titles":[{"bibliographic_title":"Kawasaki medical journal","bibliographic_titleLang":"en"}]}]},"item_10001_description_34":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Case Report","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Kawasaki Medical Society"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11482/KMJ-E202248169","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://igakkai.kms-igakkai.com/wp/wp-content/uploads/2022en/KMJ-E202248169.pdf","subitem_relation_type_select":"URI"}}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12029005","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"24343404","subitem_source_identifier_type":"EISSN"}]},"item_10001_text_32":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Clinical Oncology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Mitsugi General Hospital"},{"subitem_text_language":"en","subitem_text_value":"Department of Clinical Oncology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of General Surgery"},{"subitem_text_language":"en","subitem_text_value":"Department of Hepatology and Gastroenterology, Kawasaki Medical School・Department of Nutrition, The Faculty of Food Culture, Kurashiki Sakuyo University"},{"subitem_text_language":"en","subitem_text_value":"Department of Clinical Oncology, Kawasaki Medical School"}]},"item_10001_textarea_5":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"　Herein, a 70-year-old female was initially treated with sunitinib 50 mg/day to treat an imatinib-resistant gastrointestinal stromal tumor. After sunitinib initiation, nausea, hypertension, hepatic dysfunction, anorexia, fatigue, thrombocytopenia, epistaxis, and palmoplantar erythrodysesthesia syndrome developed; the dose was reduced to 25 mg/day.\n　Subsequently, adverse events improved, and from the fifth course onward, sunitinib 37.5 mg/day was continued. Approximately 11 months after initiating sunitinib therapy, the patient developed disturbance of consciousness, aphasia, and left hemiplegia. Computed tomography of the head revealed intracerebral hemorrhage, and the patient was hospitalized. No brain metastases, cerebral aneurysms, or cerebral arteriovenous malformations were observed. Sunitinib-induced hypertensive cerebral hemorrhage was suspected as the cause of intracerebral hemorrhage. Conservative treatments, such as antihypertensive drugs, were administered without surgical treatment. The symptoms and intracerebral hemorrhage gradually improved, and the patient was discharged from the hospital. Intracerebral hemorrhage with sunitinib is extremely rare, but has a high mortality rate. During sunitinib treatment, controlling blood pressure and thrombocytopenia is important to prevent bleeding.\n"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"YAMAMURA, Masahiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"131791","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HIRAI, Toshihiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"131792","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"OKAWAKI, Makoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"131793","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"URAKAMI, Atsushi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"131794","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"TOMIYAMA, Yasuyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"131795","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"YAMAGUCHI, Yoshiyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"131796","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-10"}],"displaytype":"detail","filename":"KMJ-E202248169.pdf","filesize":[{"value":"833.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PDF","objectType":"fulltext","url":"https://kwmed.repo.nii.ac.jp/record/3064/files/KMJ-E202248169.pdf"},"version_id":"e0eb6678-44e3-44ea-9de3-3491b5b4f17b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Gastrointestinal stromal tumor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Sunitinib","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Angiogenesis inhibitor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Intracerebral hemorrhage","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Advanced gastrointestinal stromal tumor with intracerebral hemorrhage during sunitinib treatment\\n","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Advanced gastrointestinal stromal tumor with intracerebral hemorrhage during sunitinib treatment\\n","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"31","path":["807"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-10"},"publish_date":"2023-03-10","publish_status":"0","recid":"3064","relation_version_is_last":true,"title":["Advanced gastrointestinal stromal tumor with intracerebral hemorrhage during sunitinib treatment\\n"],"weko_creator_id":"31","weko_shared_id":-1},"updated":"2024-06-05T04:55:55.701312+00:00"}