{"created":"2023-06-19T10:30:54.873230+00:00","id":3066,"links":{},"metadata":{"_buckets":{"deposit":"93bf8082-91a7-411b-a70f-d9cd4712b4b3"},"_deposit":{"created_by":31,"id":"3066","owners":[31],"pid":{"revision_id":0,"type":"depid","value":"3066"},"status":"published"},"_oai":{"id":"oai:kwmed.repo.nii.ac.jp:00003066","sets":["1709617079800:37:807"]},"author_link":["131801","131802","131803","131804","131805","131806"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"189","bibliographicPageStart":"183","bibliographicVolumeNumber":"48","bibliographic_titles":[{"bibliographic_title":"Kawasaki medical journal","bibliographic_titleLang":"en"}]}]},"item_10001_description_34":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Case Report","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Kawasaki Medical Society"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11482/KMJ-E202248183","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://igakkai.kms-igakkai.com/wp/wp-content/uploads/2022en/KMJ-E202248183.pdf","subitem_relation_type_select":"URI"}}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12029005","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"24343404","subitem_source_identifier_type":"EISSN"}]},"item_10001_text_32":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Clinical Oncology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Mitsugi General Hospital"},{"subitem_text_language":"en","subitem_text_value":"Department of Clinical Oncology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Dermatology"},{"subitem_text_language":"en","subitem_text_value":"Department of Pathology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Clinical Oncology, Kawasaki Medical School"}]},"item_10001_textarea_5":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"　A 28-year-old Japanese male was diagnosed with a gastrointestinal stromal tumor and multiple liver metastases at 23 years of age underwent gastrectomy and partial hepatectomy. At 27 year of age, multiple liver metastases and peritoneal dissemination were observed and the patient was switched to sunitinib. Approximately, one year later, the liver metastases worsened, and the patient was switched to regorafenib. Fatigue and palmar-plantar erythrodysesthesia syndrome occurred seven days after starting regorafenib, and thrombocytopenia occurred nine days later. Eleven days later, small erythema with fever and erythematous papules appeared throughout the body; therefore regorafenib was discontinued, and oral administration of steroids was initiated accordingly. After 17 days, platelets count decreased to 14,000/μL, prompting platelet transfusion. Maculopapular erythema was diagnosed based on the skin findings and histopathological examination. Oral and topical steroids were initiated and the maculopapular eruption gradually improved. A drug hypersensitivity reaction to regorafenib was diagnosed and treatment was discontinued, after which the patient entered a clinical trial for a new drug. We encountered a case of marked thrombocytopenia and maculopapular erythema during the early stages of regorafenib treatment. Regorafenib occasionally causes serious adverse events; therefore, careful observation and prompt treatment are necessary."}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"YAMAMURA, Masahiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"131801","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HIRAI, Toshihiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"131802","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"OKAWAKI, Makoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"131803","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"OKA, Daigo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"131804","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"NISHIMURA, Hirotake","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"131805","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"YAMAGUCHI, Yoshiyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"131806","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-10"}],"displaytype":"detail","filename":"KMJ-E202248183.pdf","filesize":[{"value":"2.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PDF","objectType":"fulltext","url":"https://kwmed.repo.nii.ac.jp/record/3066/files/KMJ-E202248183.pdf"},"version_id":"9793d4fb-594e-4541-8e5e-3a543bb18a5a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Regorafenib","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Thrombocytopenia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cutaneous adverse reactions","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Maculopapular erythema","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Gastrointestinal stromal tumor\\n","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Severe thrombocytopenia and maculopapular erythema-induced by regorafenib in a patient with advanced gastrointestinal stromal tumor","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Severe thrombocytopenia and maculopapular erythema-induced by regorafenib in a patient with advanced gastrointestinal stromal tumor","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"31","path":["807"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-10"},"publish_date":"2023-03-10","publish_status":"0","recid":"3066","relation_version_is_last":true,"title":["Severe thrombocytopenia and maculopapular erythema-induced by regorafenib in a patient with advanced gastrointestinal stromal tumor"],"weko_creator_id":"31","weko_shared_id":-1},"updated":"2024-06-05T04:55:59.385262+00:00"}