{"created":"2023-06-19T10:28:10.177610+00:00","id":324,"links":{},"metadata":{"_buckets":{"deposit":"96f867a0-bd6d-4e12-bf77-e389ee37ce7f"},"_deposit":{"created_by":31,"id":"324","owners":[31],"pid":{"revision_id":0,"type":"depid","value":"324"},"status":"published"},"_oai":{"id":"oai:kwmed.repo.nii.ac.jp:00000324","sets":["1709617079800:37:107:369"]},"author_link":["126436"],"item_1694495855422":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_3_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1991","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-4","bibliographicPageEnd":"45","bibliographicPageStart":"37","bibliographicVolumeNumber":"17","bibliographic_titles":[{"bibliographic_title":"Kawasaki medical journal","bibliographic_titleLang":"en"}]}]},"item_3_description_9":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Original Article","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_3_identifier_14":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"http://igakkai.kms-igakkai.com/wp/wp-content/uploads/1991en/17(1.2.3.4)37-45.1991.pdf"}]},"item_3_relation_20":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11482/KMJ-E17(1.2.3.4)37-45.1991","subitem_relation_type_select":"DOI"}}]},"item_3_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA00710169","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12029005","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-0234","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"2434-3404","subitem_source_identifier_type":"EISSN"}]},"item_3_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Psychiatry, Kawasaki Medical School"}]},"item_3_textarea_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"The role of serotonin precursor L-tryptophan and the new tetracyclic antidepressant Setiptiline Maleate in the regulation of β-and α2-adrenergic receptor was examined by Radio Receptor Assay method. Treatment with either L-tryptophan (300 mg/kg, twice, daily) or Setiptiline Maleate (3 mg/kg, twice, daily) for 14 days caused a significant decrease in the number of β-adrenergic receptors (Bmax) measured 12 hours after the last dose. Treatment with co-administration of both L-tryptophan and Setiptiline caused no significant difference from that of either L-tryptophan or Setiptiline alone. Treatment with Setiptiline caused a significant decrease in the number of α2-adrenergic receptor (Bmax), but treatment with L-tryptophan caused no change in it. Treatment with co-administration of both Setiptiline and L-tryptophan potentiated the decrease in the number of α2-adrenergic receptors compared with single administration of Setiptiline alone. "}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"KATSUDA, Yoshiaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"126436","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-01-23"}],"displaytype":"detail","filename":"KJ00010210219.pdf","filesize":[{"value":"789.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00010210219.pdf","objectType":"fulltext","url":"https://kwmed.repo.nii.ac.jp/record/324/files/KJ00010210219.pdf"},"version_id":"a5393ac6-f3d5-4264-9bb2-653b16447746"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"L-tryptophan","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Setiptiline Maleate","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"β-down regulation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"α2-dowm regulation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Monoamine interaction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Long-term treatment","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Monoamine Interaction : Effects of Long-Term Treatments with L-tryptophan and Setiptiline Maleate on Rat Brain a2- and β-adrenergic Receptor","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Monoamine Interaction : Effects of Long-Term Treatments with L-tryptophan and Setiptiline Maleate on Rat Brain a2- and β-adrenergic Receptor","subitem_title_language":"en"}]},"item_type_id":"3","owner":"31","path":["369"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-01-23"},"publish_date":"2017-01-23","publish_status":"0","recid":"324","relation_version_is_last":true,"title":["Monoamine Interaction : Effects of Long-Term Treatments with L-tryptophan and Setiptiline Maleate on Rat Brain a2- and β-adrenergic Receptor"],"weko_creator_id":"31","weko_shared_id":-1},"updated":"2023-09-28T00:19:50.332732+00:00"}