{"created":"2023-06-19T10:28:22.297520+00:00","id":519,"links":{},"metadata":{"_buckets":{"deposit":"edfdbf57-e340-42ce-8672-24922c5c3b0b"},"_deposit":{"created_by":31,"id":"519","owners":[31],"pid":{"revision_id":0,"type":"depid","value":"519"},"status":"published"},"_oai":{"id":"oai:kwmed.repo.nii.ac.jp:00000519","sets":["1709617079800:37:125:409"]},"author_link":["125666","125667","125668","125669","125670","125671","125672","125673","125674","125675","125676","125677"],"item_1694495855422":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_3_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2･3･4","bibliographicPageEnd":"78","bibliographicPageStart":"71","bibliographicVolumeNumber":"28","bibliographic_titles":[{"bibliographic_title":"Kawasaki medical journal","bibliographic_titleLang":"en"}]}]},"item_3_identifier_14":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"http://igakkai.kms-igakkai.com/wp/wp-content/uploads/2002en/28(2.3.4)71-78.2002.pdf"}]},"item_3_relation_20":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11482/KMJ28(2.3.4)71-78.2002.pdf","subitem_relation_type_select":"DOI"}}]},"item_3_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA00710169","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12029005","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-0234","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"2434-3404","subitem_source_identifier_type":"EISSN"}]},"item_3_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Endoscopy, Hiroshima University Medical Hospital"},{"subitem_text_language":"en","subitem_text_value":"Department of Endoscopy, Hiroshima University Medical Hospital"}]},"item_3_textarea_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"Our previous study demonstrated that combination treatment with cetraxate plus omeprazole, amoxicillin, and clarithromycin is effective for the eradication of Helicobacter pylon in smokers. To evaluate the effect of cetraxate on gastric mucosal blood flow (GMBF) and the gastric concentration of clarithromycin in nicotine-treated rats, 10 rats were divided into two groups given nicotine with or without cetraxate, and GMBF was measured by laser Doppler blood flowmetry. Another 36 rats were divided into three groups (control, nicotine, and nicotine + cetraxate). Clarithromycin was administered intraduodenally and nicotine was administered after 30 minutes, with cetraxate being given 30 minutes later. The gastric mucosal clarithromycin concentration was measured. After cetraxate administration, GMBF increased significantly in the nicotine + cetraxate group compared with the nicotine group (p<0.05). The mucosal clarithromycin concentration increased in the nicotine + cetraxate group compared with the nicotine group, but the difference was not significant. Our results indicate that cetraxate increased GMBF in nicotine-treated rats."}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"KAMADA, Tomoari","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HARUMA, Ken","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KUSUNOKI, Hiroaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mei, Qian Dong","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SUGIU, Kuniaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NAGASHIMA, Yuichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KOGA, Hideki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAKEDA, Masaharu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HONDA, Keisuke","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"FUJIMURA, Yoshinori","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ITO, Masanori","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TANAKA, Shinji","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-01-23"}],"displaytype":"detail","filename":"KJ00000010567.pdf","filesize":[{"value":"588.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00000010567.pdf","objectType":"fulltext","url":"https://kwmed.repo.nii.ac.jp/record/519/files/KJ00000010567.pdf"},"version_id":"ca8fd4f2-1865-437a-b03e-eeeba4749d9c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"gastric mucosal blood flow","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"nicotine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cetraxate","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"clarithromycin","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effect of Cetraxate, a Mucosal Protective Agent, on Gastric Mucosal Blood Flow and Gastric Clarithromycin Concentration in Nicotine-treated Rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of Cetraxate, a Mucosal Protective Agent, on Gastric Mucosal Blood Flow and Gastric Clarithromycin Concentration in Nicotine-treated Rats","subitem_title_language":"en"}]},"item_type_id":"3","owner":"31","path":["409"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-01-23"},"publish_date":"2017-01-23","publish_status":"0","recid":"519","relation_version_is_last":true,"title":["Effect of Cetraxate, a Mucosal Protective Agent, on Gastric Mucosal Blood Flow and Gastric Clarithromycin Concentration in Nicotine-treated Rats"],"weko_creator_id":"31","weko_shared_id":-1},"updated":"2023-10-07T02:51:32.975290+00:00"}