{"created":"2023-06-19T10:28:22.873876+00:00","id":527,"links":{},"metadata":{"_buckets":{"deposit":"71e9290c-538a-4054-b923-b44b19f2e5b8"},"_deposit":{"created_by":31,"id":"527","owners":[31],"pid":{"revision_id":0,"type":"depid","value":"527"},"status":"published"},"_oai":{"id":"oai:kwmed.repo.nii.ac.jp:00000527","sets":["1709617079800:37:148:411"]},"author_link":["125594","125595","125596","125597","125598","125599"],"item_1694495855422":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_3_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1･2","bibliographicPageEnd":"7","bibliographicPageStart":"1","bibliographicVolumeNumber":"29","bibliographic_titles":[{"bibliographic_title":"Kawasaki medical journal","bibliographic_titleLang":"en"}]}]},"item_3_identifier_14":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"http://igakkai.kms-igakkai.com/wp/wp-content/uploads/2003en/29(1.2)1-7.2003.PDF.pdf"}]},"item_3_relation_20":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11482/KMJ29(1.2)1-7.2003.PDF.pdf","subitem_relation_type_select":"DOI"}}]},"item_3_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA00710169","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12029005","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-0234","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"2434-3404","subitem_source_identifier_type":"EISSN"}]},"item_3_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Biochemistry, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Clinical Nutrition, Faculty of Medical professions, Kawasaki University of Medical Welfare"},{"subitem_text_language":"en","subitem_text_value":"Department of Biochemistry, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Biochemistry, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Division of Hematology, Department of Medicine, Faculty of Medicine, Chulalongkorn University"},{"subitem_text_language":"en","subitem_text_value":"Division of Hematology, Department of Medicine, Faculty of Medicine, Chulalongkorn University"}]},"item_3_textarea_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"We investigated the usefulness of an automated analyzer, the HLC-723G7, for determination of Hb A2 in the diagnosis of β-thalassemia. The analyzer was used for 250 Thai subjects who were either normal or were diagnosed with microcytic hypochromia based on hematological findings. An intra-assay precision test of normal subject (Hb A_2 = 2.78%) and that (Hb A_2 = 5.90%) with β-thalassemia revealed as coefficients of variation (CV%) of 3.2% and 0.95%, respectively. Samples were kept stable at 4℃ for at least 10 days. The Hb A_2 values obtained by the HLC-723G7 showed good correlation with those obtained by DEAE-HPLC with the coefficient of correlation (r) being 0.940, the coefficient of determination (R^2) 0.884, and the equation of the regression line Y_<G7> = 1.057X_<DEAE>-0.248. The subjects with a higher Hb A_2 value than about 4% were suspected of having β-thalassemia based on hematological findings. Most of those with a lower or relatively lower Hb A_2 value than the normal range (2.3-3.5%) or 4% and hematological abnormalities were considered to be suffering from α-thalassemia-1, α-thalassemia-2 or iron deficiency anemia. However, a confirmed diagnosis must be made by the further study of the red cell morphology, clinical manifestations and by the DNA analysis."}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"HARANO, Teruo","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HARANO, Keiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tin, Yi Yi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SUETSUGU, Yoshimasa","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SUTCHARITCHAN, Pranee","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SETTAPIBOON, Rung","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-01-23"}],"displaytype":"detail","filename":"KJ00000010575.pdf","filesize":[{"value":"503.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00000010575.pdf","objectType":"fulltext","url":"https://kwmed.repo.nii.ac.jp/record/527/files/KJ00000010575.pdf"},"version_id":"c7d20d3e-06f4-479e-a561-db08d8204884"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Automated Hb A_2 analyzer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"HLC-723G7","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Hemoglobin A_2 (Hb A_2)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"β-Thalassemia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"α-Thalassemia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Thalassemia diagnosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"An Automated Hb A_2 Analyzer, HLC-723G7, for Diagnosis of β-Thalassemia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"An Automated Hb A_2 Analyzer, HLC-723G7, for Diagnosis of β-Thalassemia","subitem_title_language":"en"}]},"item_type_id":"3","owner":"31","path":["411"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-01-23"},"publish_date":"2017-01-23","publish_status":"0","recid":"527","relation_version_is_last":true,"title":["An Automated Hb A_2 Analyzer, HLC-723G7, for Diagnosis of β-Thalassemia"],"weko_creator_id":"31","weko_shared_id":-1},"updated":"2023-10-10T00:33:38.878349+00:00"}