{"created":"2023-06-19T10:28:22.947954+00:00","id":528,"links":{},"metadata":{"_buckets":{"deposit":"869bf835-1cb0-42d1-92ec-c24d8bbdda99"},"_deposit":{"created_by":31,"id":"528","owners":[31],"pid":{"revision_id":0,"type":"depid","value":"528"},"status":"published"},"_oai":{"id":"oai:kwmed.repo.nii.ac.jp:00000528","sets":["1709617079800:37:148:411"]},"author_link":["125600","125601","125602"],"item_1694495855422":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_3_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1･2","bibliographicPageEnd":"16","bibliographicPageStart":"9","bibliographicVolumeNumber":"29","bibliographic_titles":[{"bibliographic_title":"Kawasaki medical journal","bibliographic_titleLang":"en"}]}]},"item_3_identifier_14":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"http://igakkai.kms-igakkai.com/wp/wp-content/uploads/2003en/29(1.2)9-16.2003.PDF.pdf"}]},"item_3_relation_20":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11482/KMJ29(1.2)9-16.2003.PDF.pdf","subitem_relation_type_select":"DOI"}}]},"item_3_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA00710169","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12029005","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-0234","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"2434-3404","subitem_source_identifier_type":"EISSN"}]},"item_3_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Clinical Nutrition, Faculty of Medical Professions,Kawasaki University of Medical Welfare"},{"subitem_text_language":"en","subitem_text_value":"Department of Biochemistry, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Biochemistry, Kawasaki Medical School"}]},"item_3_textarea_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"We had the opportunity to study the members of 10 families with Hb E/β-thalassemia and characterized the ethnic features of the population of Myanmar from haplotyping of aβ-globin-like gene cluster producing Hb E. Detection of the Hb E andβ^E-globin genes was carried out by DEAE-HPLC and isoelectric focusing of the hemolysates, by electrophoresis of DNA fragments which resulted in the digestion of the PCR product with Mn/I, and by PCR-direct sequencing. The haplotype of the β-globin-like gene cluster was determined by the presence (+) or absence (-) of the restriction enzyme site in the PCR product including the polymorphic site. Polymorphism or the haplotype were determined at seven sites, 5' to the ε-gene/HincII, in the ^Gγ-gene/HindIII, in the ^Aγ-gene/HindIII, in the ψβ-gene/HincII, 3' to the ψβ-gene/HincII, in the β-IVS II/AvaII and 3' to the β-gene/BamHI, in the β-globin-like gene cluster. Three types of haplotypes were found in this study; (a) - + - + + + - (five families), (b) + - - - - + - (four families) and (c) + - - + + + - (one family). Haplotypes (a) and (b) were identified as one's in the Thai and Cambodian populations in eastern Myanmar. They were considered to be the most common haplotypes in that area and to have been the result of gene confusion or gene flow between ethnic groups. Haplotype (c), on the other hand, was a rare type, suggesting both the specificity and diversity of ethnic groups in Myanmar."}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"HARANO, Keiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tin, Yi Yi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HARANO, Teruo","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-01-23"}],"displaytype":"detail","filename":"KJ00000010576.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00000010576.pdf","objectType":"fulltext","url":"https://kwmed.repo.nii.ac.jp/record/528/files/KJ00000010576.pdf"},"version_id":"ff6404c3-727d-4389-be0f-f4e681051112"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"hemoglobin E (Hb E)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"haplotypes","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"PCR-restriction enzyme","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"PCR-direct sequencing","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Myanmar","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Haplotypes of the β^E-Globin Gene Cluster Found in Myanmar","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Haplotypes of the β^E-Globin Gene Cluster Found in Myanmar","subitem_title_language":"en"}]},"item_type_id":"3","owner":"31","path":["411"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-01-23"},"publish_date":"2017-01-23","publish_status":"0","recid":"528","relation_version_is_last":true,"title":["Haplotypes of the β^E-Globin Gene Cluster Found in Myanmar"],"weko_creator_id":"31","weko_shared_id":-1},"updated":"2023-10-10T00:33:39.127139+00:00"}