{"created":"2023-06-19T10:28:25.370770+00:00","id":568,"links":{},"metadata":{"_buckets":{"deposit":"86667afd-88e3-410b-8271-3330666951b8"},"_deposit":{"created_by":31,"id":"568","owners":[31],"pid":{"revision_id":0,"type":"depid","value":"568"},"status":"published"},"_oai":{"id":"oai:kwmed.repo.nii.ac.jp:00000568","sets":["1709617079800:37:154:420"]},"author_link":["125407","125408","125409","125410","125411","125412","125413","125414"],"item_1694495855422":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_3_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"31","bibliographicPageStart":"23","bibliographicVolumeNumber":"40","bibliographic_titles":[{"bibliographic_title":"Kawasaki medical journal","bibliographic_titleLang":"en"}]}]},"item_3_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著","subitem_description_type":"Other"}]},"item_3_identifier_14":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"http://igakkai.kms-igakkai.com/wp/wp-content/uploads/2014en/KMJ-E40(1)23.pdf"}]},"item_3_relation_20":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11482/KMJ-E40(1)23","subitem_relation_type_select":"DOI"}}]},"item_3_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA12685295","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12029005","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-0234","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"2434-3404","subitem_source_identifier_type":"EISSN"}]},"item_3_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of General Thoracic Surgery, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of General Thoracic Surgery, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of General Thoracic Surgery, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of General Thoracic Surgery, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of General Thoracic Surgery, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of General Thoracic Surgery, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of General Thoracic Surgery, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of General Thoracic Surgery, Kawasaki Medical School"}]},"item_3_textarea_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"Vascular endothelial growth factor (VEGF) plays a key role in tumor angiogenesis. The notch ligand Delta-like ligand 4 (DLL4) is induced by VEGF and acts as a negative regulator of tumor angiogenesis by reducing the numbers of non-productive sprouting vessels. Several reports have shown the prognostic role of VEGF expression in non-small cell lung cancer. However, the correlation between VEGF and DLL4 expression and their clinical significance in non-small cell lung cancer remains unclear. The aim of this study was to analyze the correlation between the expression of VEGF/DLL4 and the clinicopathological background. Fifty-eight patients with lung adenocarcinomas measuring less than 3 cm in diameter who underwent surgical resection at Kawasaki Medical School Hospital from 2008 to 2010 were enrolled in this study. The expressions of VEGF, DLL4, CD31, and Ki-67 were analyzed using immunohistochemical staining. The tumor cells were VEGF-positive in 44 patients (75.9%) and DLL4-positive in 41 patients (70.7%). No statistically significant association was observed between the patients' characteristics and VEGF/DLL4 expression. A high VEGF expression level tended to be associated with a high DLL4 expression level (P = 0.050, r = 0.258). The mean Ki-67 index was significantly lower in the patients with high VEGF expression (9.5 vs. 18.2, P = 0.011), but no significant difference was observed when patients were compared according to their DLL4 expression levels (11.8 vs. 11.0, P = 0.804). The mean Ki-67 index was higher in the VEGF_<low> DLL4_<low> patients than in the VEGFhigh DLL4high patients by a marginally significant difference (20.1 vs. 10.9 P = 0.056). The 3-year recurrence-free survival rates of the VEGF_<high>/DLL4_<high> and the VEGF_<low>/DLL4_<low> patients were 83.3% and 35.7%, respectively. The prognosis of the VEGF_<high>/DLL4_<high> patients was significantly better than that of the VEGF_<low>/DLL4_<low> patients (P = 0.032). To investigate the significance of the difference in tumor proliferation and prognosis between the VEGF_<high>/DLL4_<high> and the VEGF_<low>/DLL4_<low> patients, we evaluated the morphologic effect of VEGF/DLL4 expression on the intratumoral capillaries by counting the number of capillaries and calculating the luminal area (μm^2). No significant differences were seen between either the VEGF or DLL4 expression levels and the mean number of intratumoral capillaries or the luminal area (μm^2). In conclusion, VEGF_<low>/DLL4_<low> patients with small pulmonary adenocarcinoma had a significantly poorer prognosis, although no significant difference in a morphological evaluation of the capillaries was seen between VEGF_<high>/DLL4_<high> and VEGF_<low>/DLL4_<low> patients."}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yasuda, Koichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"125407","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakata, Masao","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"125408","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nojima, Yuji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"125409","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maeda, Ai","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"125410","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yukawa, Takuro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"125411","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saisho, Shinsuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"125412","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okita, Riki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"125413","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimizu, Katsuhiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"125414","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-01-23"}],"displaytype":"detail","filename":"KJ00009303659.pdf","filesize":[{"value":"422.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00009303659.pdf","objectType":"fulltext","url":"https://kwmed.repo.nii.ac.jp/record/568/files/KJ00009303659.pdf"},"version_id":"72a92f5d-1bdf-47cf-b237-a9ae77af89f8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Non-small cell lung cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Adenocarcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"VEGF","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"DLL4","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Angiogenesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Clinical significance of vascular endothelial growth factor and Delta-like ligand 4 in small pulmonary adenocarcinoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Clinical significance of vascular endothelial growth factor and Delta-like ligand 4 in small pulmonary adenocarcinoma","subitem_title_language":"en"}]},"item_type_id":"3","owner":"31","path":["420"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-01-23"},"publish_date":"2017-01-23","publish_status":"0","recid":"568","relation_version_is_last":true,"title":["Clinical significance of vascular endothelial growth factor and Delta-like ligand 4 in small pulmonary adenocarcinoma"],"weko_creator_id":"31","weko_shared_id":-1},"updated":"2023-10-10T05:17:03.878812+00:00"}