| Item type |
[ELS]学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-01-23 |
| タイトル |
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|
タイトル |
Sulfamethoxazole / Trimethoprim confer no change on the clinical course of Kawasaki disease |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Kato, Atsushi
Kono, Mina
Ono, Sahoko
Inamura, Norikazu
Fukuda, Yoko
Kondo, Eisuke
Saito, Aki
Wakabayashi, Tokio
Akaike, Hiroto
Ogita, Satoko
Terada, Kihei
Ouchi, Kazunobu
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| 著者所属(英) |
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en |
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Department of Pediatrics, Kawasaki Medical School |
| 著者所属(英) |
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en |
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Department of Pediatrics, Kawasaki Medical School |
| 著者所属(英) |
|
|
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en |
|
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Department of Pediatrics, Kawasaki Medical School |
| 著者所属(英) |
|
|
|
en |
|
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Department of Pediatrics, Kawasaki Medical School |
| 著者所属(英) |
|
|
|
en |
|
|
Department of Pediatrics, Kawasaki Medical School |
| 著者所属(英) |
|
|
|
en |
|
|
Department of Pediatrics, Kawasaki Medical School |
| 著者所属(英) |
|
|
|
en |
|
|
Department of Pediatrics, Kawasaki Medical School |
| 著者所属(英) |
|
|
|
en |
|
|
Department of Pediatrics, Kawasaki Medical School |
| 著者所属(英) |
|
|
|
en |
|
|
Department of Pediatrics, Kawasaki Medical School |
| 著者所属(英) |
|
|
|
en |
|
|
Department of Pediatrics, Kawasaki Medical School |
| 著者所属(英) |
|
|
|
en |
|
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Department of Pediatrics, Kawasaki Medical School |
| 著者所属(英) |
|
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|
en |
|
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Department of Pediatrics, Kawasaki Medical School |
| キーワード |
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|
言語 |
en |
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主題Scheme |
Other |
|
主題 |
Kawasaki disease |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Sulfamethoxazole/Trimethoprim |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Heat shock protein |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Intravenous immunoglobulin therapy |
| 記事種別(英) |
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|
内容記述タイプ |
Other |
|
内容記述 |
Original Article |
|
言語 |
en |
| 抄録(英) |
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|
en |
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Kawasaki disease (KD) is one of the most common vasculitis in childhood, but its etiology is still unknown. We hypothesized that Sulfamethoxazole / Trimethoprim (S/T) would inhibit overproduction of cytokine due to heat shock protein produced by intestinal bacteria in patients with KD and improve the clinical course of KD indirectly. We have conducted a prospective study to assess the usefulness of S/T for KD. For patients with KD (S/T group, N=23), we use S/T in addition to the standard treatment in the guidelines such as intravenous immunoglobulin (IVIG) and moderate dose aspirin. The control group (non S/T group, N=32) is patients with KD treated with the standard treatment in the guidelines. The baseline characteristics did not demonstrate notable differences between the two groups. We compare duration of fever, rate of initial IVIG failure, the day of illness membranous desquamation appeared, and the occurrence of coronary artery lesion (CAL) between two groups. Membranous desquamation appeared rather earlier in S/T group than in non S/T group (11.4±3.0 day of illness vs 12.9±3.5 day of illness, P=0.078), but there was no statistically significant difference. Duration of fever (39±59 hours vs 42±57 hours, P=0.41), rate of initial IVIG failure (26% vs 31%, P=0.30), and number of CAL (8.6% vs 9.3%, P=0.87) were found no significant difference between two groups. These data indicated that the use of S/T in acute phase of KD didn't improve any clinical course of KD. |
| 書誌情報 |
en : Kawasaki medical journal
巻 40,
号 2,
p. 65-71,
発行日 2014
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| URL |
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|
識別子 |
http://igakkai.kms-igakkai.com/wp/wp-content/uploads/2014en/KMJ-E40(2)65.pdf |
|
識別子タイプ |
URI |
| DOI |
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|
識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.11482/KMJ-E40(2)65 |
| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0385-0234 |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2434-3404 |
| 雑誌書誌ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12685295 |
| 雑誌書誌ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12029005 |
| 著者版フラグ |
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|
出版タイプ |
VoR |
KJ00009578199.pdf (232.9 kB)
