{"created":"2023-06-19T10:28:27.804996+00:00","id":604,"links":{},"metadata":{"_buckets":{"deposit":"df76a1ef-aa4b-4ad3-bdf8-72c18998e3b2"},"_deposit":{"created_by":25,"id":"604","owners":[25],"pid":{"revision_id":0,"type":"depid","value":"604"},"status":"published"},"_oai":{"id":"oai:kwmed.repo.nii.ac.jp:00000604","sets":["1709617079800:35:186:430"]},"author_link":["120028","120029"],"item_1694495855422":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_3_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1987","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"159","bibliographicPageStart":"148","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"川崎医学会誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Kawasaki medical journal","bibliographic_titleLang":"en"}]}]},"item_3_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_3_identifier_14":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"http://igakkai.kms-igakkai.com/wp/wp-content/uploads/1987/KMJ13(2)148-159.1987.pdf"}]},"item_3_relation_20":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11482/KMJ-J13(2)148 ","subitem_relation_type_select":"DOI"}}]},"item_3_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00045593","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AN12940574","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0386-5924","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"2758-089X","subitem_source_identifier_type":"EISSN"}]},"item_3_text_6":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学整形外科"}]},"item_3_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Orthopedic Surgery, Kawasaki Medical School"}]},"item_3_textarea_10":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"摘出手術より得たヒト椎間板組織を使って老化アミロイド沈着の有無を調べ,椎間板変性と椎間板ヘルニアの突出度との関係を検討しさらに,そのアミロイド前駆物質について検討し以下の結果を得た.(1)88椎間中45椎間(51.1%)でアミロイド沈着を認めた.アミロイド沈着は加齢にしたがって高率に認められ,50歳以上の症例では,それ以下の年齢群に比べ有意にアミロイド沈着が高かった.性差は認められなかった.(2)後縦靱帯が保たれていた膨隆型(protrusion type)と後縦靱帯を破って突出していた脱出型(prolapse type)のアミロイド沈着率では有意差は認められなかったが,脱出型のうちfree fragmentを認める脱出遊離型では高率にアミロイド沈着を認めた.また,頸椎と腰椎によるアミロイド沈着率の差は認められなかった.(3)沈着アミロイドは,過マンガン酸カリウム処理に抵抗性であり非アミロイドA蛋白であった.PAP法を使った主要アミロイド前駆物質とも反応がなく,今までに解っているアミロイド蛋白のいずれでもない新しいタイプのものであった.このアミロイドの産生の機序は不明であるが,軟骨細胞の関与が示唆された."}]},"item_3_textarea_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"Material from intervertebral discs obtained from 88 operations for herniation of a disc and cervical spondylosis were examined histologically for amyloid deposition. Various degrees of amyloid degeneration were found in disc tissue from 45 patients. Material from patients over 50 years old showed significantly more amyloid than that from younger patients. There was no sex difference. Potassium permanganate (KMnO_4) treatment was employed for amyloid positive cases, which all had a KMnO_4 resistant amyloid. This material did not react with antibodies to known amyloid proteins. There was no preference of deposition level for the intervertebral discs and there was no difference between protrusion and prolapsed types of herniation. It was suggested that chondrocytes may comprise one of the sources of amyloid precipitation."}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"森井, 章司","creatorNameLang":"ja"},{"creatorName":"モリイ, ショウジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Morii, Shoji","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-01-23"}],"displaytype":"detail","filename":"KJ00009816539.pdf","filesize":[{"value":"5.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00009816539.pdf","objectType":"fulltext","url":"https://kwmed.repo.nii.ac.jp/record/604/files/KJ00009816539.pdf"},"version_id":"bdd547f0-7660-44c5-a1e2-4dc9dc8cf9b8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Amyloid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Intervertebral disc","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Aging","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ヒト椎間板における老化アミロイド沈着 : 椎間板変性,椎間板ヘルニアの程度との関係","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒト椎間板における老化アミロイド沈着 : 椎間板変性,椎間板ヘルニアの程度との関係","subitem_title_language":"ja"},{"subitem_title":"Senile Amyloid Deposition in Human Intervertebral Disc : Relationship to Aging and Type of Disc Herniation","subitem_title_language":"en"}]},"item_type_id":"3","owner":"25","path":["430"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-01-23"},"publish_date":"2017-01-23","publish_status":"0","recid":"604","relation_version_is_last":true,"title":["ヒト椎間板における老化アミロイド沈着 : 椎間板変性,椎間板ヘルニアの程度との関係"],"weko_creator_id":"25","weko_shared_id":-1},"updated":"2023-10-06T02:49:50.309697+00:00"}