{"created":"2023-06-19T10:28:28.756733+00:00","id":617,"links":{},"metadata":{"_buckets":{"deposit":"1f4eced0-29c8-4914-ac6c-37497358d38d"},"_deposit":{"created_by":25,"id":"617","owners":[25],"pid":{"revision_id":0,"type":"depid","value":"617"},"status":"published"},"_oai":{"id":"oai:kwmed.repo.nii.ac.jp:00000617","sets":["1709617079800:35:186:431"]},"author_link":["120214","120215","120216","120217"],"item_1694495855422":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_3_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1987","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"259","bibliographicPageStart":"252","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"川崎医学会誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Kawasaki medical journal","bibliographic_titleLang":"en"}]}]},"item_3_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_3_identifier_14":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"http://igakkai.kms-igakkai.com/wp/wp-content/uploads/1987/KMJ13(3)252-259.1987.pdf"}]},"item_3_relation_20":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11482/KMJ-J13(3)252 ","subitem_relation_type_select":"DOI"}}]},"item_3_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00045593","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AN12940574","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0386-5924","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"2758-089X","subitem_source_identifier_type":"EISSN"}]},"item_3_text_6":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"川崎医療短期大学臨床検査科"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学生化学教室"}]},"item_3_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Medical Technology, Kawasaki College of Allied Health Professions"},{"subitem_text_language":"en","subitem_text_value":"Department of Biochemistry, Kawasaki Medical School"}]},"item_3_textarea_10":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"DNAを制限酵素,Xmn IやBgl IIで消化後,γIVS II probeとhybridizationを行ったとき正常人にみられるDNAバンドのほかに大きなバンドを伴っている成人に遭遇した.末梢血液の血液学的,また化学的検査では異常は認められず,全ヘモグロビン中のHb F(%)やHb A2(%)もまた正常範囲内にあった.異常なDNAバンドは酵素分析によって調べられ,Gγ-AγGγ-AγまたはGγ-Gγ-Aγ型の三連鎖構造の存在によるものであった.この三連鎖構造を含むβ-鎖様遺伝子群のハプロタイプ,ε-遺伝子の5'Hinc II部位,Gγ-遺伝子の5'Xmn I部位,GγとAγ-遺伝子内のHind III部位,ψβ1-遺伝子内と3'Hinc II部位,β-遺伝子内のAva II部位とβ-遺伝子の3'Bam HI部位が調べられ,+--(-)----+と決定した(カッコ内の-の記号は三連鎖構造遺伝子の第二遺伝子のHind IIIポリモフィズムの不在を示す).このハプロタイプから日本人によくみられる同種のハプロタイプ,+------+,をもった染色体間の不均等交差によってγ-鎖異常配列をもった染色体が生成したものと考えられた."}]},"item_3_textarea_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"A woman possessing an abnormally large size fragment together with a normal size fragment when her DNA was digested with the restriction endonucleases Xmn I and Bgl II and was hybridized with a γIVS II probe was discovered. Hematological and chemical laboratory examinations of the peripheral blood showed no abnormalities. The contents of Hb F and Hb A2 in the total hemoglobin were within the normal range. This abnormally large size fragment was considered to be associated with the triplicatedγ-globin gene arrangement, Gγ-AγGγ-Aγ or Gγ-Gγ-Aγ by the enzymatic analysis. A family study showed that her mother had the same abnormal gene arrangement. The haplotype of the β-like gene cluster including γ-globin gene triplication, Hinc II 5' to the ε-gene, Xmn I 5' to the Gγ-gene, Hind III within the Gγ- and Aγ-genes, Hinc II within and 3' to the ψβ1-genes, Ava II within the β-gene and Bam HI 3' to the β-gene, was decided as +--(-)----+ (the minus sign in the parentheses means the absence of Hind III polymorphism within the second γ-globin gene in the triplicated γ-globin gene arrangement). This newly produced β-like globin gene cluster might be derived by crossing over between two chromosomes having the same haplotype, +------+, which is more common in Japanese."}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"土井, 和子","creatorNameLang":"ja"},{"creatorName":"ドイ, カズコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"原野, 昭雄","creatorNameLang":"ja"},{"creatorName":"ハラノ, テルオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Doi, Kazuko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Harano, Teruo","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-01-23"}],"displaytype":"detail","filename":"KJ00009816799.pdf","filesize":[{"value":"889.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00009816799.pdf","objectType":"fulltext","url":"https://kwmed.repo.nii.ac.jp/record/617/files/KJ00009816799.pdf"},"version_id":"c2bab8fc-3e09-4b0d-8b1a-5083157998bb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Human γ-globin gene","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"γ-Globin gene triplication","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Unequal crossover","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"β-Like gene haplotype","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"正常成人にみられたγ-鎖グロビン遺伝子の配列異常","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"正常成人にみられたγ-鎖グロビン遺伝子の配列異常","subitem_title_language":"ja"},{"subitem_title":"Abnormal Arrangement of theγ-Globin Gene Found in a Normal Adult","subitem_title_language":"en"}]},"item_type_id":"3","owner":"25","path":["431"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-01-23"},"publish_date":"2017-01-23","publish_status":"0","recid":"617","relation_version_is_last":true,"title":["正常成人にみられたγ-鎖グロビン遺伝子の配列異常"],"weko_creator_id":"25","weko_shared_id":-1},"updated":"2023-10-06T04:23:04.631794+00:00"}