{"created":"2023-06-19T10:28:28.977335+00:00","id":620,"links":{},"metadata":{"_buckets":{"deposit":"d5a73c26-27fd-450f-ba58-c64c3c12484f"},"_deposit":{"created_by":25,"id":"620","owners":[25],"pid":{"revision_id":0,"type":"depid","value":"620"},"status":"published"},"_oai":{"id":"oai:kwmed.repo.nii.ac.jp:00000620","sets":["1709617079800:35:186:431"]},"author_link":["120232","120233"],"item_1694495855422":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_3_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1987","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"294","bibliographicPageStart":"279","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"川崎医学会誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Kawasaki medical journal","bibliographic_titleLang":"en"}]}]},"item_3_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_3_identifier_14":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"http://igakkai.kms-igakkai.com/wp/wp-content/uploads/1987/KMJ13(3)279-294.1987.pdf"}]},"item_3_relation_20":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11482/KMJ-J13(3)279 ","subitem_relation_type_select":"DOI"}}]},"item_3_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00045593","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AN12940574","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0386-5924","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"2758-089X","subitem_source_identifier_type":"EISSN"}]},"item_3_text_6":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学大学院形態系超微形態病理学III"}]},"item_3_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Division of Nephrology, Department of Medicine, Kawasaki Medical School"}]},"item_3_textarea_10":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"糸球体基底膜の選択透過性異常の原因として,基底膜合成に関与していると考えられる糸球体上皮細胞の態度が注目される.一方,ラットにN,N'-Diacetylbenzidine(N,N'-DAB)を投与すると,蛋白尿と上皮細胞の特異な病理変化が出現することが知られている.著者は,この上皮細胞の病理変化と蛋白尿の関係を明らかにするためにN,N'-DABをラットの腹腔内に1回または2回投与し,観察した.投与後40日に蛋白尿が出現し始め,100日には多くの個体で蛋白尿が陽性化し,200日にわたって300mg/日以上の尿蛋白が持続増強した. 形態的には糸球体上皮細胞に空胞状変化が出現し,蛋白尿の程度に伴って係蹄硬化性変化,硝子化巣が出現し,増悪した.推計学的には,上皮細胞の空胞状変化は,蛋白尿の出現に先行していた.このことは糸球体上皮細胞の空胞性病変のなかには,薬剤による原発性の細胞障害によって発現したものがある可能性を示す."}]},"item_3_textarea_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"The glomerular epithelial cells are assumed to synthesize basement membrane. Therefore, pathological changes in glomerular epithelial cells are noteworthy as a cause of abnormal permselectivity of the glomerular basement membrane. Administration of N, N'-Diacetylbenzidine (N, N'-DAB) to rats causes proteinuria and characteristic pathological epithelial cell changes. The author investigated N, N'-DAB injected rats and attempted to clarify the relationship between proteinuria and pathological epithelial cell changes. The first evidence of proteinuria among the rats appeared 40 days after the beginning of the experiment and most of the rats had proteinuria at the end of 100 days. Then proteinuria increased to over 300mg/day and continued to the 200th experimental day. Morphological observations just of all revealed glomerular epithelial cell vacuolization. Focal hyalinosis and capillary sclerotic lesions also appeared and spread gradually with the progress of proteinuria. Statistically, the glomerular epithelial vacuolizations appeared before the beginning of proteinuria. This indicates that some vacuolization of the epithelial cells is the result of drug induced degenerative changes in the cytoplasm rather than absorptive vacuoles."}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松谷, 拓郎","creatorNameLang":"ja"},{"creatorName":"マツタニ, タクロウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"120232","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsutani, Takuro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"120233","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-01-23"}],"displaytype":"detail","filename":"KJ00009816839.pdf","filesize":[{"value":"9.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00009816839.pdf","objectType":"fulltext","url":"https://kwmed.repo.nii.ac.jp/record/620/files/KJ00009816839.pdf"},"version_id":"b5f3c7a3-0b39-4fb1-97f6-081a3e864b12"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Glomerular epithelial cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Epithelial vacuole","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Proteinuria","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ベンチジン誘導体によるラット腎障害の形態的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ベンチジン誘導体によるラット腎障害の形態的研究","subitem_title_language":"ja"},{"subitem_title":"Morphological Study of Benzidine Derivative Induced Rat Nephropathy","subitem_title_language":"en"}]},"item_type_id":"3","owner":"25","path":["431"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-01-23"},"publish_date":"2017-01-23","publish_status":"0","recid":"620","relation_version_is_last":true,"title":["ベンチジン誘導体によるラット腎障害の形態的研究"],"weko_creator_id":"25","weko_shared_id":-1},"updated":"2023-10-06T04:23:10.120297+00:00"}