{"created":"2023-06-19T10:28:29.557737+00:00","id":628,"links":{},"metadata":{"_buckets":{"deposit":"3929b0a9-61db-48f2-8e56-0b5dc1770712"},"_deposit":{"created_by":25,"id":"628","owners":[25],"pid":{"revision_id":0,"type":"depid","value":"628"},"status":"published"},"_oai":{"id":"oai:kwmed.repo.nii.ac.jp:00000628","sets":["1709617079800:35:186:432"]},"author_link":["120322","120323","120324","120325","120326","120327"],"item_1694495855422":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_3_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1987","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"346","bibliographicPageStart":"339","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"川崎医学会誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Kawasaki medical journal","bibliographic_titleLang":"en"}]}]},"item_3_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_3_identifier_14":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"http://igakkai.kms-igakkai.com/wp/wp-content/uploads/1987/KMJ13(4)339-346.1987.pdf"}]},"item_3_relation_20":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11482/KMJ-J13(4)339 ","subitem_relation_type_select":"DOI"}}]},"item_3_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00045593","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AN12940574","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0386-5924","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"2758-089X","subitem_source_identifier_type":"EISSN"}]},"item_3_text_6":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学泌尿器科"},{"subitem_text_language":"ja","subitem_text_value":"川崎医科大学泌尿器科"},{"subitem_text_language":"ja","subitem_text_value":"SRL特殊検査部"}]},"item_3_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Urology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Urology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Immunochemical Research, Special Reference Laboratory Inc"}]},"item_3_textarea_10":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"近年,体液中のフィブロネクチン濃度の測定が種々の疾病の診断や病態を知る上で,臨床上重要な情報を与えてくれつつある.われわれは,簡便でかつ迅速なfibronectin・EIA(FN・EIA)キットを用いて尿中フィブロネクチンを測定し,その基礎的検討ならびに健常人の基準値の設定を試みた.本法は固相を用いたサンドウィッチ法による酵素免疫測定法(EIA)で,再現性,希釈による直線性にすぐれ,添加回収も良好で16～1000ng/mlの広範囲で測定することができた.検体の保存は-20℃としポリチューブを用いた.測定は室温で施行し,比較的安定した反応系が得られた.日内変動も大きな差はなく,腎機能による影響もほとんど認められなかった.健常人155名による尿中フィブロネクチン値は,加齢とともに上昇傾向が認められたが,年齢別の検討では20歳代が最も低値を示した.女性に比し男性の方がやや高値を示した.なお,cut off値は160ng/mlであった.今後各種疾患に対し,尿中フィブロネクチン濃度の測定を行って,その機能と病態との関連を解明し,臨床に大いに役立てられるものと考えられた."}]},"item_3_textarea_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"In the present study, the urinary FN values in normal controls and in patients with various urological diseases were measured by the sandwich EIA method (MBL kit). A standard curve was found to be sensitive in the range of 16ng/ml to 1000ng/ml. The respective rates of CV were below 10% in the dilution test and the reproducibility test. The mean rate obtained was 99.4% in the additive recovery test. No particular diurnal changes in the urinary FN values were detected and the spontaneous urine discharged in the morning was measured. More than 95% of 155 normal controls showed FN values of below 160ng/ml and the cut off value was determined as 160ng/ml. The value was slightly higher in males than in females. By age group, the lowest value was recorded in the 20s and the values tended to increase with advancing age. The correlation coefficient between FN values and creatinine values in the urine was r=0.218 and the effect of the renal function on the FN value was considered to be almost negligible. The urinary FN values in the patients were generally higher than in controls, but the clinical characteristics were difficult to be determined in this study."}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中塚, 繁治","creatorNameLang":"ja"},{"creatorName":"ナカツカ, シゲハル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"田中, 啓幹","creatorNameLang":"ja"},{"creatorName":"タナカ, ヒロヨシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大野, 安男","creatorNameLang":"ja"},{"creatorName":"オオノ, ヤスオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakatsuka, Shigeharu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Hiroyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ono, Yasuo","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-01-23"}],"displaytype":"detail","filename":"KJ00009816979.pdf","filesize":[{"value":"814.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00009816979.pdf","objectType":"fulltext","url":"https://kwmed.repo.nii.ac.jp/record/628/files/KJ00009816979.pdf"},"version_id":"d8ff8506-7ddb-4ff6-831c-90a600602991"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Urinary fibronectin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Enzyme immunoassay","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"尿中フィブロネクチンに関する研究 (1)基礎的検討と基準値の設定","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"尿中フィブロネクチンに関する研究 (1)基礎的検討と基準値の設定","subitem_title_language":"ja"},{"subitem_title":"Clinical Evaluation of Urinary Fibronectin (1) Modification of Its Method and Reference Values","subitem_title_language":"en"}]},"item_type_id":"3","owner":"25","path":["432"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-01-23"},"publish_date":"2017-01-23","publish_status":"0","recid":"628","relation_version_is_last":true,"title":["尿中フィブロネクチンに関する研究 (1)基礎的検討と基準値の設定"],"weko_creator_id":"25","weko_shared_id":-1},"updated":"2023-10-06T04:41:23.195213+00:00"}