{"created":"2023-06-19T10:27:54.997697+00:00","id":80,"links":{},"metadata":{"_buckets":{"deposit":"4f321f8f-894e-46dc-ac3f-d62475a406c7"},"_deposit":{"created_by":3,"id":"80","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"80"},"status":"published"},"_oai":{"id":"oai:kwmed.repo.nii.ac.jp:00000080","sets":["1709617079800:37:46:332"]},"author_link":["127426","127421","127423","127425","127422","127424"],"item_3_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1983","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"107","bibliographicPageStart":"99","bibliographicVolumeNumber":"9","bibliographic_titles":[{},{"bibliographic_title":"Kawasaki medical journal","bibliographic_titleLang":"en"}]}]},"item_3_description_9":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Original Article","subitem_description_type":"Other"}]},"item_3_identifier_14":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"http://igakkai.kms-igakkai.com/wp/wp-content/uploads/1983en/9(2)99-107.1983.pdf | http://igakkai.kms-igakkai.com/wp/wp-content/uploads/1983en/9(2)99-107.1983.pdf"}]},"item_3_relation_20":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11482/KMJ-E9(2)99 ","subitem_relation_type_select":"DOI"}}]},"item_3_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA00710169","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12029005","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-0234","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"2434-3404","subitem_source_identifier_type":"ISSN"}]},"item_3_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Division of Respratory Disease, Department of Medicine, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Division of Respratory Disease, Department of Medicine, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Division of Respratory Disease, Department of Medicine, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Division of Respratory Disease, Department of Medicine, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Division of Respratory Disease, Department of Medicine, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Division of Respratory Disease, Department of Medicine, Kawasaki Medical School"}]},"item_3_textarea_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"We measured the plasma levels of tobramycin administered by different methods and evaluated the therapeutic effects of tobramycin in mice with experimental pneumonia in various methods and dose schedules. (1) Mice were dosed with tobramycin intramuscular, intravenous oneshot injection and drip infusion, and intramuscular injection in divided doses at intervals of 15 minutes. The plasma concentration of the drug was determined at timed intervals after administration in each instance. Intramuscular and one-shot intravenous injections resulted in substantially parallel time courses of plasma concentration and plasma concentration with drip infusion was similar to that after divided intramuscular injection. (2) A therapeutic experiment was conducted in mice with Klebsiella pneumoniae pneumonia using one-shot and divided intramuscular injection methods of tobramycin. The one-shot injection group showed a satisfactory result at the dose level of 2 mg/kg, but the injection in four divided doses yielded better results at 1 mg/kg. Therefore, in cases where high doses are not feasible or are undesirable, the time of contact of the bacteria and the drug should be prolonged, rather than trying to increase the peak plasma concentration of the drug. "}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"SOEJIMA, Rinzo","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NIKI, Yoshihito","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KAWANISHI, Masayasu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MATSUSHIMA, Toshiharu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KATOH, Osamu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NAKAHAMA, Chikara","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-01-23"}],"displaytype":"detail","filename":"KJ00010227619.pdf","filesize":[{"value":"705.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00010227619.pdf","url":"https://kwmed.repo.nii.ac.jp/record/80/files/KJ00010227619.pdf"},"version_id":"5b06fc74-4f5b-405f-a44a-9918463c6759"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Plasma concentration of tobramycin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Klebsiella pneumoniae pneumonia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Formaldehyde","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"inhaledmou se","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Therapeutic effect of tobramycin","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Investigation of the Therapeutic Effect of Tobramycin in Mice with Experimental Pneumonia in One-shot Versus Divided-dose Schedules","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Investigation of the Therapeutic Effect of Tobramycin in Mice with Experimental Pneumonia in One-shot Versus Divided-dose Schedules","subitem_title_language":"en"}]},"item_type_id":"3","owner":"3","path":["332"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-01-23"},"publish_date":"2017-01-23","publish_status":"0","recid":"80","relation_version_is_last":true,"title":["Investigation of the Therapeutic Effect of Tobramycin in Mice with Experimental Pneumonia in One-shot Versus Divided-dose Schedules"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T10:56:09.350954+00:00"}