| Item type |
[ELS]学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-01-23 |
| タイトル |
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|
タイトル |
A Neuropathologic Study of Disseminated Necrotizing Leukoencephalopathy Following Intrathecal Methotrexate Therapy |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
SHIRABE, Teruo
FUKUYA, Takashi
ASAKI, Hideki
|
| 著者所属(英) |
|
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|
en |
|
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Division of Human Pathology (Neuropathology), Department of Pathology, Kawasaki Medical School |
| 著者所属(英) |
|
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|
en |
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Division of Human Pathology (Neuropathology), Department of Pathology, Kawasaki Medical School |
| 著者所属(英) |
|
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|
en |
|
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Department of pediatrics, Kawasaki Medical School |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
methotrexate encephalopathy |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
disseminated necrotizing leukencephalopathy |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
intrathecal methotrexate therapy |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
meningeal leukemia |
| 記事種別(英) |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Original Article |
|
言語 |
en |
| 抄録(英) |
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|
en |
|
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Neuropathologic findings of a case of disseminated necrotizing leukoencephalopathy following intrathecal methotrexate therapy are described. A five-year-old boy with acute lymphocytic leukemia was seen over a twenty-two month course and was administered methotrexate intrathecally for meningeal leukemia. After the seventh intrathecal administration he developed akinetic mutism and decorticated rigidity which persisted until the patient's death seventeen months later. Neuropathologically, there were widespread necrotic lesions with scattered lipid-laden macrophages and extensive astrocytic gliosis mainly in the white matter of the cerebrum and cerebellum in addition to meningeal and perivascular infiltration by leukemia cells. Nerve cell loss was considerable in the thalamus, cerebellar cortex, dentate nucleus, pontine nucleus and inferior olivary nucleus. The disseminated necrotizing leukoencephalopathy in this case was thought to be caused mainly by the direct toxic effect of intrathecally administered methotrexate and not by irradiation or leukemia cell infiltration. |
| 書誌情報 |
en : Kawasaki medical journal
巻 9,
号 3,
p. 157-166,
発行日 1983
|
| URL |
|
|
識別子 |
http://igakkai.kms-igakkai.com/wp/wp-content/uploads/1983en/9(3)157-166.1983.pdf |
|
識別子タイプ |
URI |
| DOI |
|
|
|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.11482/KMJ-E9(3)157 |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0385-0234 |
| ISSN |
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|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2434-3404 |
| 雑誌書誌ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00710169 |
| 雑誌書誌ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12029005 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
KJ00010228919.pdf (3.8 MB)
