WEKO3
アイテム
{"_buckets": {"deposit": "8bd562ba-e201-4def-8202-deaf1ea406a6"}, "_deposit": {"created_by": 3, "id": "1895", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "1895"}, "status": "published"}, "_oai": {"id": "oai:kwmed.repo.nii.ac.jp:00001895", "sets": ["612"]}, "author_link": ["125251", "125250", "125256", "125249", "125254", "125255", "125252", "125253"], "item_10001_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "93", "bibliographicPageStart": "79", "bibliographicVolumeNumber": "43", "bibliographic_titles": [{}, {"bibliographic_title": "Kawasaki medical journal", "bibliographic_titleLang": "en"}]}]}, "item_10001_description_34": {"attribute_name": "記事種別(英)", "attribute_value_mlt": [{"subitem_description": "Regular Article", "subitem_description_type": "Other"}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Kawasaki Medical Society"}]}, "item_10001_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.11482/KMJ-E43(2)79", "subitem_relation_type_select": "DOI"}}]}, "item_10001_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "http://igakkai.kms-igakkai.com/wp/wp-content/uploads/2017en/KMJ-E43(2)79.pdf"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://igakkai.kms-igakkai.com/wp/wp-content/uploads/2017en/KMJ-E43(2)79.pdf", "subitem_relation_type_select": "URI"}}]}, "item_10001_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA12685295", "subitem_source_identifier_type": "NCID"}, {"subitem_source_identifier": "AA12029005", "subitem_source_identifier_type": "NCID"}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0385-0234", "subitem_source_identifier_type": "ISSN"}, {"subitem_source_identifier": "2434-3404", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_text_32": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Department of Pathology, Kawasaki Medical School"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pathology, Kawasaki Medical School"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pathology, Kawasaki Medical School"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pathology, Kawasaki Medical School"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pathology, Kawasaki Medical School"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Hematology, Kawasaki Medical School"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Hematology, Kawasaki Medical School"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pathology, Kawasaki Medical School"}]}, "item_10001_textarea_5": {"attribute_name": "抄録(英)", "attribute_value_mlt": [{"subitem_textarea_language": "en", "subitem_textarea_value": "Resident bone marrow macrophages provide a microenvironment for erythropoiesis, forming erythroblastic islands (EBIs) via adhesion molecules. In this study, we examined vascular cell adhesion molecule-1 (VCAM-1) expression in human bone marrow specimens using immunohistochemistry. VCAM-1 was strongly expressed in CD169+ macrophages in EBIs and weakly in sinusoidal vascular endothelial cells. In reactive erythropoiesis, including hemolytic and megaloblastic anemia, the extended cytoplasm of VCAM-1+ CD169+ macrophages circumscribed the erythroid cells. The strong affinity between VCAM-1+ macrophages and erythroid cells was also observed in polycythemia vera (PV), essential thrombocythemia (ET), and chronic myelogenous leukemia (CML). VCAM-1 density was significantly higher in PV than in ET and CML (p \u003c 0.001), and correlated with blood erythrocyte count in all three neoplasms (p \u003c 0.001). In ET, the VCAM-1 density was higher in cases with the JAK2 mutation than with the CALR mutation. In myelodysplastic syndrome with erythroid predominance but unclear EBI formation, punctate VCAM-1+ cytoplasmic processes of macrophages were seen between erythroblasts, similar to those seen between granulocytic precursors in CML, suggesting incomplete contact of VCAM-1+ macrophages with dysplastic erythroid cells. These results suggest that VCAM-1+ macrophages create a niche for reactive and neoplastic erythropoiesis and may be a therapeutic target in PV."}]}, "item_10001_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "FUJIWARA, Hideyo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "125249", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "NISHIMURA, Hirotake", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "125250", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "IREI, Isao", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "125251", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "AKIYAMA, Takashi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "125252", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "HAMAZAKI, Shuji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "125253", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "WADA, Hideho", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "125254", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "SUGIHARA, Takashi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "125255", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "SADAHIRA, Yoshito", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "125256", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-03-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KMJ-E43(2)79.pdf", "filesize": [{"value": "1.5 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1500000.0, "url": {"label": "PDF", "url": "https://kwmed.repo.nii.ac.jp/record/1895/files/KMJ-E43(2)79.pdf"}, "version_id": "40b4653a-70ef-41e6-9042-be6c63883c7d"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "adhesion", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "erythropoiesis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "macrophages", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "polycythemia vera", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "VCAM-1", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Human bone marrow VCAM-1+ macrophages provide a niche for reactive and neoplastic erythropoiesis", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Human bone marrow VCAM-1+ macrophages provide a niche for reactive and neoplastic erythropoiesis", "subitem_title_language": "en"}]}, "item_type_id": "10001", "owner": "3", "path": ["612"], "permalink_uri": "https://kwmed.repo.nii.ac.jp/records/1895", "pubdate": {"attribute_name": "公開日", "attribute_value": "2018-03-01"}, "publish_date": "2018-03-01", "publish_status": "0", "recid": "1895", "relation": {}, "relation_version_is_last": true, "title": ["Human bone marrow VCAM-1+ macrophages provide a niche for reactive and neoplastic erythropoiesis"], "weko_shared_id": -1}
Human bone marrow VCAM-1+ macrophages provide a niche for reactive and neoplastic erythropoiesis
https://kwmed.repo.nii.ac.jp/records/1895
https://kwmed.repo.nii.ac.jp/records/189579a893fa-b45e-4eb8-8c26-7c24e810aa43
名前 / ファイル | ライセンス | アクション |
---|---|---|
PDF (1.5 MB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2018-03-01 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Human bone marrow VCAM-1+ macrophages provide a niche for reactive and neoplastic erythropoiesis | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
FUJIWARA, Hideyo
× FUJIWARA, Hideyo× NISHIMURA, Hirotake× IREI, Isao× AKIYAMA, Takashi× HAMAZAKI, Shuji× WADA, Hideho× SUGIHARA, Takashi× SADAHIRA, Yoshito |
|||||
著者所属(英) | ||||||
en | ||||||
Department of Pathology, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Pathology, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Pathology, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Pathology, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Pathology, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Hematology, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Hematology, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Pathology, Kawasaki Medical School | ||||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | adhesion | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | erythropoiesis | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | macrophages | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | polycythemia vera | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | VCAM-1 | |||||
抄録(英) | ||||||
en | ||||||
Resident bone marrow macrophages provide a microenvironment for erythropoiesis, forming erythroblastic islands (EBIs) via adhesion molecules. In this study, we examined vascular cell adhesion molecule-1 (VCAM-1) expression in human bone marrow specimens using immunohistochemistry. VCAM-1 was strongly expressed in CD169+ macrophages in EBIs and weakly in sinusoidal vascular endothelial cells. In reactive erythropoiesis, including hemolytic and megaloblastic anemia, the extended cytoplasm of VCAM-1+ CD169+ macrophages circumscribed the erythroid cells. The strong affinity between VCAM-1+ macrophages and erythroid cells was also observed in polycythemia vera (PV), essential thrombocythemia (ET), and chronic myelogenous leukemia (CML). VCAM-1 density was significantly higher in PV than in ET and CML (p < 0.001), and correlated with blood erythrocyte count in all three neoplasms (p < 0.001). In ET, the VCAM-1 density was higher in cases with the JAK2 mutation than with the CALR mutation. In myelodysplastic syndrome with erythroid predominance but unclear EBI formation, punctate VCAM-1+ cytoplasmic processes of macrophages were seen between erythroblasts, similar to those seen between granulocytic precursors in CML, suggesting incomplete contact of VCAM-1+ macrophages with dysplastic erythroid cells. These results suggest that VCAM-1+ macrophages create a niche for reactive and neoplastic erythropoiesis and may be a therapeutic target in PV. | ||||||
書誌情報 |
en : Kawasaki medical journal 巻 43, 号 2, p. 79-93, 発行日 2017 |
|||||
出版者 | ||||||
出版者 | Kawasaki Medical Society | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0385-0234 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2434-3404 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12685295 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12029005 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.11482/KMJ-E43(2)79 | |||||
記事種別(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Regular Article | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://igakkai.kms-igakkai.com/wp/wp-content/uploads/2017en/KMJ-E43(2)79.pdf | |||||
関連名称 | http://igakkai.kms-igakkai.com/wp/wp-content/uploads/2017en/KMJ-E43(2)79.pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |