| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-03-01 |
| タイトル |
|
|
タイトル |
Human bone marrow VCAM-1+ macrophages provide a niche for reactive and neoplastic erythropoiesis |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
FUJIWARA, Hideyo
NISHIMURA, Hirotake
IREI, Isao
AKIYAMA, Takashi
HAMAZAKI, Shuji
WADA, Hideho
SUGIHARA, Takashi
SADAHIRA, Yoshito
|
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Pathology, Kawasaki Medical School |
| 著者所属(英) |
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|
言語 |
en |
|
値 |
Department of Pathology, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Pathology, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Pathology, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Pathology, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Hematology, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Hematology, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Pathology, Kawasaki Medical School |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
adhesion |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
erythropoiesis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
macrophages |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
polycythemia vera |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
VCAM-1 |
| 抄録(英) |
|
|
言語 |
en |
|
値 |
Resident bone marrow macrophages provide a microenvironment for erythropoiesis, forming erythroblastic islands (EBIs) via adhesion molecules. In this study, we examined vascular cell adhesion molecule-1 (VCAM-1) expression in human bone marrow specimens using immunohistochemistry. VCAM-1 was strongly expressed in CD169+ macrophages in EBIs and weakly in sinusoidal vascular endothelial cells. In reactive erythropoiesis, including hemolytic and megaloblastic anemia, the extended cytoplasm of VCAM-1+ CD169+ macrophages circumscribed the erythroid cells. The strong affinity between VCAM-1+ macrophages and erythroid cells was also observed in polycythemia vera (PV), essential thrombocythemia (ET), and chronic myelogenous leukemia (CML). VCAM-1 density was significantly higher in PV than in ET and CML (p < 0.001), and correlated with blood erythrocyte count in all three neoplasms (p < 0.001). In ET, the VCAM-1 density was higher in cases with the JAK2 mutation than with the CALR mutation. In myelodysplastic syndrome with erythroid predominance but unclear EBI formation, punctate VCAM-1+ cytoplasmic processes of macrophages were seen between erythroblasts, similar to those seen between granulocytic precursors in CML, suggesting incomplete contact of VCAM-1+ macrophages with dysplastic erythroid cells. These results suggest that VCAM-1+ macrophages create a niche for reactive and neoplastic erythropoiesis and may be a therapeutic target in PV. |
| 書誌情報 |
en : Kawasaki medical journal
巻 43,
号 2,
p. 79-93,
発行日 2017
|
| 出版者 |
|
|
出版者 |
Kawasaki Medical Society |
|
言語 |
en |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0385-0234 |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2434-3404 |
| 書誌レコードID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12685295 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12029005 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.11482/KMJ-E43(2)79 |
| 記事種別(英) |
|
|
内容記述 |
Regular Article |
|
言語 |
en |
| 関連サイト |
|
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|
識別子タイプ |
URI |
|
|
関連識別子 |
http://igakkai.kms-igakkai.com/wp/wp-content/uploads/2017en/KMJ-E43(2)79.pdf |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
PDF (1.5 MB)
