WEKO3
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院内肺炎重症群(C群)に対するTazobactam/Piperacillin, Pazufloxacin 併用療法の有効性と安全性に関する検討
https://kwmed.repo.nii.ac.jp/records/2170
https://kwmed.repo.nii.ac.jp/records/21702ba4a8fe-092e-4d57-9b18-d04db52e3762
名前 / ファイル | ライセンス | アクション |
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PDF (891.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-04-01 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 院内肺炎重症群(C群)に対するTazobactam/Piperacillin, Pazufloxacin 併用療法の有効性と安全性に関する検討 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Clinical effect and safety of Tazobactam/Piperacillin and Pazufloxacin combination therapy on hospital-acquired pneumonia severe group (C group) | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
沖本, 二郎
× 沖本, 二郎× 小山, 勝正× 福田, 直樹× 栗原, 武幸× 宮下, 修行× 友田, 恒一× OKIMOTO, Niro× KOYAMA, Katsumasa× FUKUDA, Naoki× KURIHARA, Takeyuki× MIYASHITA, Naoyuki× TOMODA, Koichi |
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著者所属(日) | ||||||
ja | ||||||
川崎医科大学総合内科学1 | ||||||
著者所属(日) | ||||||
ja | ||||||
川崎医科大学総合内科学1 | ||||||
著者所属(日) | ||||||
ja | ||||||
川崎医科大学総合内科学1 | ||||||
著者所属(日) | ||||||
ja | ||||||
川崎医科大学総合内科学1 | ||||||
著者所属(日) | ||||||
ja | ||||||
川崎医科大学総合内科学1 | ||||||
著者所属(日) | ||||||
ja | ||||||
川崎医科大学総合内科学1 | ||||||
著者所属(英) | ||||||
en | ||||||
Department of General Internal Medicine 1, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of General Internal Medicine 1, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of General Internal Medicine 1, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of General Internal Medicine 1, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of General Internal Medicine 1, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of General Internal Medicine 1, Kawasaki Medical School | ||||||
キーワード | ||||||
言語 | ja | |||||
主題Scheme | Other | |||||
主題 | 院内肺炎 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Tazobactam/Piperacillin | |||||
キーワード | ||||||
言語 | ja | |||||
主題Scheme | Other | |||||
主題 | Pazufloxacin | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Hospital-acquired pneumonia | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Tazobactam/Piperacillin | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Pazufloxacin | |||||
抄録(日) | ||||||
ja | ||||||
院内肺炎重症群(C群)に対するTazobactam/Piperacillin(TAZ/PIPC),Pazufloxacin(PZFX)併用療法の有効性と安全性を検討した.院内肺炎重症群(C 群)20例を対象とし,TAZ/PIPC 1回4.5g,1日3回, PZFX 1回500mg,1日2回の併用投与を行い,その臨床効果,細菌学的効果,副作用などにつき検討した.その結果,臨床効果は,有効率60.0%(20例中12例有効)であった.細菌学的効果は,除菌率69.2%(13株中9株除菌)であり,Escherichia coli 3株中3株,Streptococcus pneumoniae 2株中2株,methicillin-sensitive Staphylococcus aureus ,Serratiamarcescense 各々1株中1株,Enterococcus faealis ,Pseudomonas aeruginosa 各々2株中1株が除菌された.副作用として,注射部位静脈炎が3例(15.0%)にみられ,臨床検査値の異常変動は8例(40.0%:肝機能障害4例,腎機能障害4例)にみられたが,いずれも軽度であった.以上より,TAZ/PIPC, PZFX 併用投与は,院内肺炎重症群(C群)に対して推奨できる治療法と考えられた. | ||||||
抄録(英) | ||||||
en | ||||||
The clinical effect and safety of Tazobactam/piperacillin and Pazufloxacin combination therapy on hospital-acquired pneumonia severe group (C group) was evaluated. Twenty patients were treated by combination of TAZ/PIPC (4.5g per dose, 3 times daily) and PZFX (500mg per dose, twice daily) . Clinical effect, bacteriological effect, and adverse events were examined. Clinical efficacy rate was 60.0% (effectiveness in 12 of 20 patients). As for bacteriological effect, 3 of 3 Escherichia coli strais , 2 of 2 Streptococcus pneumoniae strains, 1 of 1 methicillin-sensitive Staphylococcus aureus strain and Serratia marcescense strain respectively, 1 of 2 Enterococcus faealis strains and Pseudomonas aeruginosa strains respectively were eradicated. In total, 9 (69.2%) of 13 strains were eradicated. Adverse events were infection site phlebitis in 3 patients (15.0%), and abnormal laboratory findings were observed including mild liver dysfunction in 4 patients and mild renal dysfunction in 4 patients. Consequently, TAZ/PIPC and PZFX combination therapy is recommended for hospital-acquired pneumonia severe group(C group). |
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書誌情報 |
ja : 川崎医学会誌 en : Kawasaki medical journal 巻 45, p. 49-53, 発行日 2019 |
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出版者 | ||||||
言語 | ja | |||||
出版者 | 川崎医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0386-5924 | |||||
ISSN | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 2758-089X | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00045593 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN12940574 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.11482/KMJ-J201945049 | |||||
記事種別(日) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 原著論文 | |||||
言語 | ja | |||||
記事種別(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Regular Article | |||||
言語 | en | |||||
医中誌ID | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | ICHUSHI | |||||
関連識別子 | 2020200375 | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://igakkai.kms-igakkai.com/wp/wp-content/uploads/2019/KMJ-J201945049.pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |