| Item type |
[ELS]学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-01-23 |
| タイトル |
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タイトル |
An Automated Hb A_2 Analyzer, HLC-723G7, for Diagnosis of β-Thalassemia |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
HARANO, Teruo
HARANO, Keiko
Tin, Yi Yi
SUETSUGU, Yoshimasa
SUTCHARITCHAN, Pranee
SETTAPIBOON, Rung
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| 著者所属(英) |
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en |
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Department of Biochemistry, Kawasaki Medical School |
| 著者所属(英) |
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en |
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Department of Clinical Nutrition, Faculty of Medical professions, Kawasaki University of Medical Welfare |
| 著者所属(英) |
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en |
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Department of Biochemistry, Kawasaki Medical School |
| 著者所属(英) |
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en |
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Department of Biochemistry, Kawasaki Medical School |
| 著者所属(英) |
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en |
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Division of Hematology, Department of Medicine, Faculty of Medicine, Chulalongkorn University |
| 著者所属(英) |
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en |
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Division of Hematology, Department of Medicine, Faculty of Medicine, Chulalongkorn University |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
Automated Hb A_2 analyzer |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
HLC-723G7 |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
Hemoglobin A_2 (Hb A_2) |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
β-Thalassemia |
| キーワード |
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言語 |
en |
|
主題Scheme |
Other |
|
主題 |
α-Thalassemia |
| キーワード |
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言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Thalassemia diagnosis |
| 抄録(英) |
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en |
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We investigated the usefulness of an automated analyzer, the HLC-723G7, for determination of Hb A2 in the diagnosis of β-thalassemia. The analyzer was used for 250 Thai subjects who were either normal or were diagnosed with microcytic hypochromia based on hematological findings. An intra-assay precision test of normal subject (Hb A_2 = 2.78%) and that (Hb A_2 = 5.90%) with β-thalassemia revealed as coefficients of variation (CV%) of 3.2% and 0.95%, respectively. Samples were kept stable at 4℃ for at least 10 days. The Hb A_2 values obtained by the HLC-723G7 showed good correlation with those obtained by DEAE-HPLC with the coefficient of correlation (r) being 0.940, the coefficient of determination (R^2) 0.884, and the equation of the regression line Y_<G7> = 1.057X_<DEAE>-0.248. The subjects with a higher Hb A_2 value than about 4% were suspected of having β-thalassemia based on hematological findings. Most of those with a lower or relatively lower Hb A_2 value than the normal range (2.3-3.5%) or 4% and hematological abnormalities were considered to be suffering from α-thalassemia-1, α-thalassemia-2 or iron deficiency anemia. However, a confirmed diagnosis must be made by the further study of the red cell morphology, clinical manifestations and by the DNA analysis. |
| 書誌情報 |
en : Kawasaki medical journal
巻 29,
号 1･2,
p. 1-7,
発行日 2003
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| URL |
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|
識別子 |
http://igakkai.kms-igakkai.com/wp/wp-content/uploads/2003en/29(1.2)1-7.2003.PDF.pdf |
|
識別子タイプ |
URI |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.11482/KMJ29(1.2)1-7.2003.PDF.pdf |
| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0385-0234 |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2434-3404 |
| 雑誌書誌ID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA00710169 |
| 雑誌書誌ID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA12029005 |
| 著者版フラグ |
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出版タイプ |
VoR |
KJ00000010575.pdf (503.6 kB)
