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An Automated Hb A_2 Analyzer, HLC-723G7, for Diagnosis of β-Thalassemia
https://kwmed.repo.nii.ac.jp/records/527
https://kwmed.repo.nii.ac.jp/records/5279f5d57d8-3d20-490a-a395-4b04ecca39e2
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00000010575.pdf (503.6 kB)
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| Item type | [ELS]学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-01-23 | |||||
| タイトル | ||||||
| タイトル | An Automated Hb A_2 Analyzer, HLC-723G7, for Diagnosis of β-Thalassemia | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
HARANO, Teruo
× HARANO, Teruo× HARANO, Keiko× Tin, Yi Yi× SUETSUGU, Yoshimasa× SUTCHARITCHAN, Pranee× SETTAPIBOON, Rung |
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| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Department of Biochemistry, Kawasaki Medical School | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Department of Clinical Nutrition, Faculty of Medical professions, Kawasaki University of Medical Welfare | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Department of Biochemistry, Kawasaki Medical School | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Department of Biochemistry, Kawasaki Medical School | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Division of Hematology, Department of Medicine, Faculty of Medicine, Chulalongkorn University | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Division of Hematology, Department of Medicine, Faculty of Medicine, Chulalongkorn University | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Automated Hb A_2 analyzer | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | HLC-723G7 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Hemoglobin A_2 (Hb A_2) | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | β-Thalassemia | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | α-Thalassemia | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Thalassemia diagnosis | |||||
| 抄録(英) | ||||||
| 言語 | en | |||||
| 値 | We investigated the usefulness of an automated analyzer, the HLC-723G7, for determination of Hb A2 in the diagnosis of β-thalassemia. The analyzer was used for 250 Thai subjects who were either normal or were diagnosed with microcytic hypochromia based on hematological findings. An intra-assay precision test of normal subject (Hb A_2 = 2.78%) and that (Hb A_2 = 5.90%) with β-thalassemia revealed as coefficients of variation (CV%) of 3.2% and 0.95%, respectively. Samples were kept stable at 4℃ for at least 10 days. The Hb A_2 values obtained by the HLC-723G7 showed good correlation with those obtained by DEAE-HPLC with the coefficient of correlation (r) being 0.940, the coefficient of determination (R^2) 0.884, and the equation of the regression line Y_<G7> = 1.057X_<DEAE>-0.248. The subjects with a higher Hb A_2 value than about 4% were suspected of having β-thalassemia based on hematological findings. Most of those with a lower or relatively lower Hb A_2 value than the normal range (2.3-3.5%) or 4% and hematological abnormalities were considered to be suffering from α-thalassemia-1, α-thalassemia-2 or iron deficiency anemia. However, a confirmed diagnosis must be made by the further study of the red cell morphology, clinical manifestations and by the DNA analysis. | |||||
| 書誌情報 |
en : Kawasaki medical journal 巻 29, 号 1･2, p. 1-7, 発行日 2003 |
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| URL | ||||||
| 識別子 | http://igakkai.kms-igakkai.com/wp/wp-content/uploads/2003en/29(1.2)1-7.2003.PDF.pdf | |||||
| 識別子タイプ | URI | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.11482/KMJ29(1.2)1-7.2003.PDF.pdf | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0385-0234 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2434-3404 | |||||
| 雑誌書誌ID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00710169 | |||||
| 雑誌書誌ID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA12029005 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
