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Potentiating and Depressing Actions of Caffeine on Twitch Tension in the Isolated Atrial Muscle of the Bullfrog
https://kwmed.repo.nii.ac.jp/records/136
https://kwmed.repo.nii.ac.jp/records/136a4261dae-5608-4a3b-a7ed-cc31f7d098e3
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
PDF (14.4 MB)
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| Item type | [ELS]学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2017-01-23 | |||||||||
| タイトル | ||||||||||
| タイトル | Potentiating and Depressing Actions of Caffeine on Twitch Tension in the Isolated Atrial Muscle of the Bullfrog | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| 著者 |
CHEN, Xiao-Liang
× CHEN, Xiao-Liang
× MATSUMURA, Moto
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| 著者所属(英) | ||||||||||
| en | ||||||||||
| Department of Physiology, Beijing Second Medical College | ||||||||||
| 著者所属(英) | ||||||||||
| en | ||||||||||
| Department of Phsiology, Kawasaki Medical School | ||||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Cardiac muscle | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Muscle contraction | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Caffeine | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Excitation-contraction coupling | |||||||||
| 記事種別(英) | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | Original Article | |||||||||
| 言語 | en | |||||||||
| 抄録(英) | ||||||||||
| en | ||||||||||
| Caffeine shows the dual actions on the twitch tension of isolated atrial muscles of bullfrogs. When the preparation, which is repetitively stimulated at the rate of 6/min, is exposed to Ringer solutions containing caffeine of 1, 2, 5 and 10 mM, the twitch tension first increases in 0.52 min and then decreases exponentially with the time constants of 4.5-6.2 min. Namely, the actions of caffeine are biphasic; the initial potentiation and the following depression. The time constants are independent of concentrations of either caffeine or of external calcium. The initial potentiation is explained from the increased sensitivity of troponin to Ca and the following slow decay is explained from the depletion of stored Ca inside the sarcoplasmic reticulum. After washout of caffeine solution, the twitch tension further decreases transiently and then recovers slowly to the control tension. These tension changes during the recovery seem to be a mirror image of the tension changes observed during caffeine exposure. The 90% recovery time, however, is prolonged by an increase in caffeine concentration and is shortened by an increase in calcium concentration. The explanations are that the transient tension drop is produced by the removal of the potentiating action and that the slow tension recovery is produced by the reaccumulation of calcium into the sarcoplasmic reticulum. | ||||||||||
| 書誌情報 |
en : Kawasaki medical journal 巻 11, 号 1, p. 1-10, 発行日 1985 |
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| URL | ||||||||||
| 識別子 | http://igakkai.kms-igakkai.com/wp/wp-content/uploads/1985en/11(1)1-10.1985.pdf | |||||||||
| 識別子タイプ | URI | |||||||||
| DOI | ||||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | https://doi.org/10.11482/KMJ-E11(1)1 | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 0385-0234 | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | EISSN | |||||||||
| 収録物識別子 | 2434-3404 | |||||||||
| 雑誌書誌ID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA00710169 | |||||||||
| 雑誌書誌ID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA12029005 | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
