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Relation Between Polycythemia and Function of Hemoglobin with Amino Acid Substitution in α1β2 Contact Hb Chesapeake [α92 (FG4) Arg→Leu ]and Hb J Cape Town [α92 (FG 4) Arg→Gln]
https://kwmed.repo.nii.ac.jp/records/141
https://kwmed.repo.nii.ac.jp/records/14118e34ed2-6101-42b1-9e8e-3fcad57325ed
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00010223199.pdf (21.1 MB)
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| Item type | [ELS]学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2017-01-23 | |||||||
| タイトル | ||||||||
| タイトル | Relation Between Polycythemia and Function of Hemoglobin with Amino Acid Substitution in α1β2 Contact Hb Chesapeake [α92 (FG4) Arg→Leu ]and Hb J Cape Town [α92 (FG 4) Arg→Gln] | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| 著者 |
MORI, H Hiroo
× MORI, H Hiroo
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| 著者所属(英) | ||||||||
| en | ||||||||
| Department of Clinical Pathology, Kawasaki Medical School | ||||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | Abnormal hemoglobin | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | Hb Chesapeake | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | Hb J Cape Town | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | Polycythemia | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | Erythropoietin | |||||||
| 記事種別(英) | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | Original Article | |||||||
| 言語 | en | |||||||
| 抄録(英) | ||||||||
| en | ||||||||
| Two variants of abnormal hemoglobins with increased oxygen affinity, Hb Chesapeake (α92 Arg→Leu) and Hb J Cape Town (α92 Arg →Gln), were detected by isoelectric focusing during a population survey of residents of Aichi Prefecture. This was the first time for these abnormal hemoglobins to be found in Japanese. Following this discovery, a comparative study of the two variants was carried out employing isoelectric focusing, structural analysis (fingerprinting and amino acid analysis), functional analysis (oxygen equilibrium), dissociation into dimers, autoxidation, biosynthesis, and plasma erythropoietin level measurement. The carriers of Hb Chesapeake, who were heterozygous for the abnormal hemoglobin, showed mild polycythemia. Those of Hb J Cape Town, however, were free of polycythemia, although their hematological values (RBC, Ht and Hb) were close to the upper limits of the normal ranges. The results of the present study support the view that increased production of erythropoietin due to a tissue oxygen deficiency is not the only decisive factor for causation of polycythemia in variant hemoglobins with high oxygen affinity. | ||||||||
| 書誌情報 |
en : Kawasaki medical journal 巻 11, 号 1, p. 41-56, 発行日 1985 |
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| URL | ||||||||
| 識別子 | http://igakkai.kms-igakkai.com/wp/wp-content/uploads/1985en/11(1)41-56.1985.pdf | |||||||
| 識別子タイプ | URI | |||||||
| DOI | ||||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | https://doi.org/10.11482/KMJ-E11(1)41 | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 0385-0234 | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | EISSN | |||||||
| 収録物識別子 | 2434-3404 | |||||||
| 雑誌書誌ID | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA00710169 | |||||||
| 雑誌書誌ID | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA12029005 | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
