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The Effects of Estrogen and Antiestrogen on Chromatin in Human Breast Cancer Cell Line, MCF-7. II.
https://kwmed.repo.nii.ac.jp/records/161
https://kwmed.repo.nii.ac.jp/records/161539602bb-6cc7-46a5-b221-0a1ac6ebf350
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00010224259.pdf (478.5 kB)
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| Item type | [ELS]学術雑誌論文 / Journal Article(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2017-01-23 | |||||||
| タイトル | ||||||||
| タイトル | The Effects of Estrogen and Antiestrogen on Chromatin in Human Breast Cancer Cell Line, MCF-7. II. | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| 著者 |
IKEDA, Mitsunori
× IKEDA, Mitsunori
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| 著者所属(英) | ||||||||
| en | ||||||||
| Department of Biochemistry, Kawasaki Medical School | ||||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | Estrogen | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | Antiestrogen | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | Chromatin | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | MCF-7 cell | |||||||
| 記事種別(英) | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | Original Article | |||||||
| 言語 | en | |||||||
| 抄録(英) | ||||||||
| en | ||||||||
| The effects of estrogen and antiestrogen on chromatin in a human breast cancer cell line, MCF-7, were studied in cells grown in media containing 10-8 M estradiol or 10-6 M tamoxifen for 1, 3 and 8 days. The effect on incorporation of thymidine into DNA was determined. Maximal incorporation occurred on day 1 after administration of estradiol, but was depressed to a low level within 3-8 days. A small increase in incorporation was observed on 1-3 days after administration of tamoxifen, but this was also depressed to a low level within 8 days. The uptake of [32P]orthophosphate into an individual protein band was observed using sodium dodecyl sulfate-polyacrylamide gels in chromatin from the cells on day 1 after administration of estradiol and tamoxifen. The difference in the action mechanisms of estradiol and tamoxifen may be explained in part by the uptake of phosphate into individual protein. The results of the present experiments may be due to influence of either estradiol and tamoxifen on the cell cycle as well. | ||||||||
| 書誌情報 |
en : Kawasaki medical journal 巻 11, 号 3, p. 169-175, 発行日 1985 |
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| URL | ||||||||
| 識別子 | http://igakkai.kms-igakkai.com/wp/wp-content/uploads/1985en/11(3)169-175.1985.pdf | |||||||
| 識別子タイプ | URI | |||||||
| DOI | ||||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | https://doi.org/10.11482/KMJ-E11(3)169 | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 0385-0234 | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | EISSN | |||||||
| 収録物識別子 | 2434-3404 | |||||||
| 雑誌書誌ID | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA00710169 | |||||||
| 雑誌書誌ID | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA12029005 | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
