| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-09-29 |
| タイトル |
|
|
タイトル |
Skewing T helper cells exposed to asbestos fibers toward reduction of tumor immunity or activation of autoimmunity |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
KUMAGAI-TAKEI, Naoko
LEE, Suni
MATSUZAKI, Hidenori
MAEDA, Megumi
YU, Min
SADA, Nagisa
YOSHITOME, Kei
NISHIMURA, Yasumitsu
OTSUKI, Takemi
|
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Hygiene, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Hygiene, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Life Sciences, Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Biofunctional Chemistry, Graduate School of Environmental and Life Science, Okayama University |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Hygiene, Kawasaki Medical School・Department of Occupational and Environmental Health Science, School of Public Health, Peking University・Department of Occupational Diseases, Zhejiang, Academy of Medical Sciences |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Hygiene, Kawasaki Medical School・Department of Biophysical Chemistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Hygiene, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Hygiene, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Hygiene, Kawasaki Medical School |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Asbestos |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Anti-tumor immunity |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Autoimmunity |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
CXCR3 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
IL-17 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Regulatory T cell |
| 抄録(英) |
|
|
言語 |
en |
|
値 |
Asbestos fibers cause malignant tumors such as lung cancer and malignant mesothelioma. Furthermore, with carcinogenic activity, they alter the human immune system. Our previous findings indicated that immune cells exposed to asbestos revealed cellular and molecular alterations that resulted in a reduction in anti-tumor immunity. Focusing on regulatory T cells (Tregs), we found enhanced function and proliferating activity resulting from asbestos exposure using an in vitro cell line model. Additionally, surface C-X-C motif chemokine receptor 3 (CXCR3) levels in T helper (Th) cells as well as the capacity to produce interferon γ were reduced, which lead to decreased anti-tumor immunity. However, our recent findings showed that IL-17 production in the intracellular CXCR3-rich fraction in Th cells was enhanced by asbestos exposure. Regarding alterations of autoimmunity, some investigators have reported the detection of autoantibodies against endothelial cells and mesothelial cells in an asbestosexposed mouse model and suggested that these autoantibodies contribute to the formation of pulmonary fibrosis. However, the precise mechanisms by which asbestos affects the human immune system and causes cancers and the production of certain autoantibodies to create pathophysiological conditions found in asbestos-exposed patients remains to be elucidated. |
| 書誌情報 |
en : Kawasaki medical journal
巻 44,
号 1,
p. 33-40,
発行日 2018
|
| 出版者 |
|
|
出版者 |
Kawasaki Medical Society |
|
言語 |
en |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0385-0234 |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2434-3404 |
| 書誌レコードID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12685295 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12029005 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.11482/KMJ-E44(1)33 |
| 記事種別(英) |
|
|
内容記述 |
Review |
|
言語 |
en |
| 関連サイト |
|
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|
識別子タイプ |
URI |
|
|
関連識別子 |
http://igakkai.kms-igakkai.com/wp/wp-content/uploads/2018en/KMJ-E44(1)33.pdf |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
PDF (1.4 MB)
