| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-06-26 |
| タイトル |
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タイトル |
The deficient of eNOS-NO pathway exacerbates kidney dysfunction via inflammasome activation in diabetic kidney disease |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Reina, UMENO
Hajime, NAGASU
Masanobu, TAKASU
Natsumi, INOUE
Rie, TATSUGAWA
Eriko, KAJIMOTO
Akira, HIRANO
Tsukasa, IWAKURA
Yoshihisa, WADA
Hiroyuki, KADOYA
Kengo, KIDOKORO
Seiji, KISHI
Shun’ichiro, TANIGUCHI
Masafumi, TAKAHASHI
Tamaki, SASAKI
Naoki, KASHIHARA
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| 著者所属(英) |
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en |
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Departments of Nephrology and Hypertension |
| 著者所属(英) |
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en |
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Departments of Nephrology and Hypertension |
| 著者所属(英) |
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en |
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Departments of Nephrology and Hypertension |
| 著者所属(英) |
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en |
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Departments of Nephrology and Hypertension |
| 著者所属(英) |
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en |
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Departments of Nephrology and Hypertension |
| 著者所属(英) |
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en |
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Departments of Nephrology and Hypertension |
| 著者所属(英) |
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en |
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Departments of Nephrology and Hypertension |
| 著者所属(英) |
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en |
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Departments of Nephrology and Hypertension |
| 著者所属(英) |
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en |
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Departments of Nephrology and Hypertension |
| 著者所属(英) |
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en |
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Departments of General Geriatric Medicine, Kawasaki Medical School |
| 著者所属(英) |
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en |
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Departments of Nephrology and Hypertension |
| 著者所属(英) |
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en |
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Departments of Nephrology and Hypertension |
| 著者所属(英) |
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en |
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Advanced Cancer Medicine for Gynecologic Cancer, Kagoshima University Graduate School of Medical and Dental Sciences |
| 著者所属(英) |
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en |
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Division of Inflammation Research, Center for Molecular Medicine, Jichi Medical University |
| 著者所属(英) |
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en |
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Departments of Nephrology and Hypertension |
| 著者所属(英) |
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en |
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Faculty of Medicine, Kawasaki Medical School |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
Endothelial cell |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
ASC-deficient mice |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
Chronic inflammation |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
Diabetes mellitus |
| キーワード |
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主題Scheme |
Other |
| 抄録(英) |
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en |
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ABSTRACT Background: Diabetic kidney disease (DKD) is a major cause of end-stage kidney disease. We have reported that inflammasome activation is involved in the pathogenesis of kidney disease and that the disruption of the endothelial nitric oxide synthase (eNOS)- nitric oxide (NO) pathway promotes inflammasome activation and renal interstitial inflammation in hypertensive and aging kidney models. Endothelial dysfunction, which is involved in the pathogenesis of renal injury, may regulate inflammasome activation. However, it is not known whether endothelial dysfunction promotes the progression of DKD via inflammasome activation.<br>Methods: Apoptosis-associated speck-like protein (ASC) is one of the components constituting the inflammasome. We crossed eNOS-deficient mice (eNOSKO) with ASC-deficient mice to create eNOS-ASC-double-deficient mice (eNOS-ASC-DKO). C57BL / 6 (WT), eNOSKO and eNOS-ASC-DKO were administered streptozotocin (STZ) to induce diabetes. Urine storage and blood pressure measurements were taken in these groups. Eight weeks after the onset of diabetes, they were sacrificed and examined. Tissue damage was examined by PAS staining, Masson staining, and tissue immunohistochemistry.<br>Results: The exacerbation of glomerular lesions were observed in eNOSKO-STZ mice. Kidney injury molecule-1 (KIM-1) positive impaired proximal tubules increased as well. The interstitial fibrosis was significantly increased. These changes were rescued by ASC deficiency. In addition, macrophage infiltrated into the glomeruli in eNOS-deficient mice. Interestingly, these inflammatory cell infiltrations were suppressed in eNOS-ASC-DKO-STZ mice.<br>Conclusions: This study used a DKD model to demonstrate the impact of endothelial dysfunction on chronic inflammation. The results indicate that controlling inflammasome activation may inhibit the progression of kidney disease. |
| 書誌情報 |
en : Kawasaki medical journal
巻 49,
p. 47-55,
発行日 2023
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| 出版者 |
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出版者 |
Kawasaki Medical Society |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
03850234 |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
24343404 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA12029005 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.11482/KMJ-E202349047 |
| 記事種別(英) |
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内容記述 |
Regular Article |
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言語 |
en |
| 関連サイト |
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識別子タイプ |
URI |
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|
関連識別子 |
https://igakkai.kms-igakkai.com/wp/wp-content/uploads/2023en/KMJ-E202349047.pdf |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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