| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2020-04-01 |
| タイトル |
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タイトル |
The diagnostic accuracy of biomarkers for the prediction of bacteremia in patients with suspected infection: a prospective observational study |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
SHIINO, Yasukazu
MIYATA, Ippei
INOUE, Takahiro
MIYAMOTO, Satomi
HOTTA, Toshihiro
TAKAHASHI, Jiro
YAMADA, Sachiko
TAKEHARA, Nobuharu
OUCHI, Kazunobu
OGINO, Ryukoh
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| 著者所属(英) |
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en |
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Department of Acute Medicine, Kawasaki Medical School |
| 著者所属(英) |
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en |
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Department of Pediatrics, Kawasaki Medical School |
| 著者所属(英) |
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en |
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Department of Acute Medicine, Kawasaki Medical School |
| 著者所属(英) |
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en |
|
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Department of Acute Medicine, Kawasaki Medical School |
| 著者所属(英) |
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en |
|
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Department of Acute Medicine, Kawasaki Medical School |
| 著者所属(英) |
|
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en |
|
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Department of Acute Medicine, Kawasaki Medical School |
| 著者所属(英) |
|
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|
en |
|
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Department of Acute Medicine, Kawasaki Medical School |
| 著者所属(英) |
|
|
|
en |
|
|
Department of Acute Medicine, Kawasaki Medical School |
| 著者所属(英) |
|
|
|
en |
|
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Department of Pediatrics, Kawasaki Medical School |
| 著者所属(英) |
|
|
|
en |
|
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Department of Acute Medicine, Kawasaki Medical School |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
Bacteremia |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Procalcitonin |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Presepsin |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Early diagnosis |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Diagnostic test |
| 抄録(英) |
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|
en |
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Rapid recognition of bacteremia is important for critical care, especially in patients with suspected bloodstream infections. Procalcitonin and presepsin are widely used biomarkers in point-of care medical testing for identifying infectious diseases and sepsis; however, the diagnostic accuracy for the prediction of bacteremia is not well established. Therefore, this study aimed to evaluate the diagnostic accuracy of procalcitonin and presepsin for the prediction of bacteremia in patients with suspected bacteremia. We performed a prospective observational study at our hospital. A total of 210 patients (307 samples) who had been admitted from December 2014 through September 2016 with a suspected infection were included. Presepsin and procalcitonin were tested simultaneously with blood cultures and routine laboratory tests. One hundred and four blood samples were obtained at the emergency room (ER). Others were obtained during hospital admission. Blood cultures were positive in 34 samples; 25 samples were obtained in the ER. Presepsin and procalcitonin levels were significantly higher in patients with positive blood cultures than in those with negative blood cultures (1028.5 pg/mL vs. 485.0 pg/mL, P < 0.001 and 4.53 ng/mL vs. 0.33 ng/mL, P < 0.001, respectively). For predicting bacteremia, receiver operating characteristic curve analysis for presepsin showed an area under the curve (AUC) of 0.718 and negative predictive value (NPV) of 95%. The analysis for procalcitonin showed an AUC of 0.778 and NPV of 94.8%. C-reactive protein tests and the quick Sequential Organ Failure Assessment score in the ER failed to be useful tools for predicting bacteremia. Based on our results, procalcitonin and presepsin showed good diagnostic accuracy and NPV for predicting bacteremia among patients with suspected infection. Therefore, these biomarkers may be useful for ruling out bacteremia in patients with suspected infection. |
| 書誌情報 |
en : Kawasaki medical journal
巻 45,
p. 27-35,
発行日 2019
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| 出版者 |
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出版者 |
Kawasaki Medical Society |
| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
03850234 |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
24343404 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA12685295 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12029005 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.11482/KMJ-E201945027 |
| 記事種別(英) |
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内容記述 |
Regular Article |
|
言語 |
en |
| 医中誌ID |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
ICHUSHI |
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関連識別子 |
2020354375 |
| 関連サイト |
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識別子タイプ |
URI |
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関連識別子 |
http://igakkai.kms-igakkai.com/wp/wp-content/uploads/2019en/KMJ-E201945027.pdf |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
PDF (796.7 kB)
