| Item type |
[ELS]学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-01-23 |
| タイトル |
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|
タイトル |
Alterations in Synthesis of Various Connective Tissue Components in Werner's Syndrome Cultured Dermal Fibroblasts |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
TAKEDA, Koji
HATAMOCHI, Atsushi
UEKI, Hiroaki
|
| 著者所属(英) |
|
|
|
en |
|
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Department of Dermatology, Kawasaki Medical School |
| 著者所属(英) |
|
|
|
en |
|
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Department of Dermatology, Kawasaki Medical School |
| 著者所属(英) |
|
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|
en |
|
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Department of Dermatology, Kawasaki Medical School |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Werner's syndrome |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
collagen sythesis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
glycosaminoglycan synthesis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
dermal fibroblast |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
connective tissue |
| 記事種別(英) |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Original Article |
|
言語 |
en |
| 抄録(英) |
|
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|
en |
|
|
Werner's syndrome (WS), a premature aging disorder, is known to have scleroderma-like skin changes. We studied both collagen and glycosaminoglycan (GAG) synthesis in dermal fibroblasts derived from two patients with WS. The total synthesized protein was determined by the incorporation of [3H]-proline, and the synthesized collagen was measured as labeled hydroxyproline. The GAG synthesis was measured by the incorporation of [3H]-glucosamine. The synthesis of total and collagenous protein of fibroblasts from WS was increased about threefold respective to controls. The GAG synthesis of fibroblasts from WS patients was also significantly higher than normal controls. These results suggest that the connective tissue synthesis in WS might be common to be that of scleroderma in the active phase. |
| 書誌情報 |
en : Kawasaki medical journal
巻 13,
号 3,
p. 111-116,
発行日 1987
|
| URL |
|
|
識別子 |
http://igakkai.kms-igakkai.com/wp/wp-content/uploads/1987en/13(3)111-116.1987.pdf |
|
識別子タイプ |
URI |
| DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.11482/KMJ-E13(3)111 |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0385-0234 |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2434-3404 |
| 雑誌書誌ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00710169 |
| 雑誌書誌ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12029005 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
KJ00010220119.pdf (643.9 kB)
