| Item type |
[ELS]学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-01-23 |
| タイトル |
|
|
タイトル |
Fibroblast-Lymphocyte-Macrophage Interaction in Erythema Nodosum-like Lesions of Behcet's Syndrome: An Ultrastructural Study |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
HONMA, Takayoshi
BANG, Dongsik
SAITO, Taiichi
NAKAGAWA, Shojiro
UEKI, Hiroaki
|
| 著者所属(英) |
|
|
|
en |
|
|
Department of Pharmacology, Kawasaki Medical School |
| 著者所属(英) |
|
|
|
en |
|
|
Department of Dermatology, Yonsei University Wonju College of Medicine |
| 著者所属(英) |
|
|
|
en |
|
|
Department of Pharmacology, Kawasaki Medical School |
| 著者所属(英) |
|
|
|
en |
|
|
Department of Dermatology, Kawasaki Medical School |
| 著者所属(英) |
|
|
|
en |
|
|
Department of Dermatology, Kawasaki Medical School |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Behcet's syndrome |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
erythema nodosum-like lesion |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
fibroblast activation |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
emperipolesis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
cell-cell interaction |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
electron microscopy |
| 記事種別(英) |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Original Article |
|
言語 |
en |
| 抄録(英) |
|
|
|
en |
|
|
In this study biopsy specimens of erythema nodosum-like lesions from eighteen patients with Behfet's syndrome were examined with the electron microscope to elucidate the close relationship between lymphocytes and/or macrophages and fibroblasts in the perivascular regions of the dermis and subcutaneous fat accompanied by prominent edematous changes and extensive depletion of collagen fibers. Electron microscopic evaluation revealed lymphocyte emperipolesis as a special pattern of adhesion of lymphocytes to fibroblasts in 3-4 days after the onset of the skin lesions. The emperipoletic lymphocytes as well as the lymphocytes adhering to fibroblasts contained a number of polyribosomes and few organelles in the cytoplasm. The fibroblasts with these lymphocytes showed remarkable development of rough endoplasmic reticulum and any other cytoplasmic organelles, indicating activated cellular function as collagen synthesis. Adhesion of lymphocytes to fibroblasts was followed by adhesion to macrophages. In the triads of lymphocyte-fibroblast-macrophage, morphological profiles of the fibroblasts showed involutional changes suggestive of suppressed cellular function through their cytoplasmic lobulation. Our findings indicate that fibroblasts are regulated directly by adhesion of lymphocytes and/or macrophages in fibrous repair of the erythema nodosum-like lesions of Behcet's syndrome. |
| 書誌情報 |
en : Kawasaki medical journal
巻 14,
号 2,
p. 63-74,
発行日 1988
|
| URL |
|
|
識別子 |
http://igakkai.kms-igakkai.com/wp/wp-content/uploads/1988en/14(2)63-74.1988.pdf |
|
識別子タイプ |
URI |
| DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.11482/KMJ-E14(2)63 |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0385-0234 |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2434-3404 |
| 雑誌書誌ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00710169 |
| 雑誌書誌ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12029005 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
KJ00010217679.pdf (12.4 MB)
